Medicine Information

D-2000

Name: D-2000
Brand: D-2000
Rating: 4.5 (117 reviews)

Tablet2000 IUVitamins, Vitamin D preparationATC: A11CC05

Generic Name

Cholecalciferol (Vitamin D3) 2000 IU Tablet

Manufacturer

General Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
d 2000 2000 iu tablet	৳ 2.50	৳ 25.00

Description

Overview of the medicine

D-2000 2000 IU Tablet contains Cholecalciferol, which is Vitamin D3. It is essential for calcium and phosphate absorption, bone mineralization, and immune system function. It is primarily used to prevent and treat Vitamin D deficiency.

Uses & Indications

Prevention and treatment of Vitamin D deficiency.

Adjuvant in the treatment of osteoporosis.

Hypoparathyroidism.

Rickets and osteomalacia.

Malabsorption syndromes (e.g., celiac disease, Crohn's disease) where Vitamin D deficiency is a concern.

Dosage

Adults

For Vitamin D deficiency, typically 2000 IU daily or as directed by a physician. For maintenance, 800-2000 IU daily.

Elderly

Similar to adult dosage, but often higher dosages are recommended due to reduced skin synthesis and absorption.

Renal_impairment

Caution is advised. Active vitamin D metabolites may be preferred in severe renal failure. Consult a physician.

How to Take

Take orally, preferably with the largest meal of the day to enhance absorption, as Vitamin D is fat-soluble. Do not crush or chew the tablet unless specifically advised.

Mechanism of Action

Cholecalciferol (Vitamin D3) is converted in the liver to 25-hydroxyvitamin D (calcifediol) and then in the kidneys to the active form, 1,25-dihydroxyvitamin D (calcitriol). Calcitriol acts on intestinal cells to increase calcium absorption, on bone to regulate calcium and phosphate metabolism, and on kidneys to reduce calcium excretion. It also plays a role in immune modulation and cell growth.

Pharmacokinetics

Onset

Effects on calcium levels typically seen within 1-2 days, but full benefits on bone health take weeks to months.

Excretion

Primarily excreted in bile and feces. A small amount is excreted in urine.

Half life

The elimination half-life of 25-hydroxyvitamin D (calcifediol) is approximately 15-30 days. The active form, 1,25-dihydroxyvitamin D (calcitriol), has a shorter half-life of about 4-6 hours.

Absorption

Well absorbed from the gastrointestinal tract in the presence of bile salts. Enhanced by fatty meals.

Metabolism

Primarily hydroxylated in the liver to 25-hydroxyvitamin D, then further hydroxylated in the kidneys to 1,25-dihydroxyvitamin D (active form).

Side Effects

Contraindications

Hypercalcemia (high blood calcium levels)
Hypervitaminosis D (Vitamin D toxicity)
Hypersensitivity to Cholecalciferol or any components of the formulation
Severe renal impairment with hyperphosphatemia (unless hypercalcemia is present)

Drug Interactions

Corticosteroids

May reduce the effects of Vitamin D.

Thiazide diuretics

May increase the risk of hypercalcemia.

Phenobarbital, Phenytoin

May increase Vitamin D metabolism, reducing its effects.

Cardiac glycosides (e.g., Digoxin)

Hypercalcemia caused by Vitamin D can potentiate the effects of cardiac glycosides, increasing the risk of arrhythmias.

Cholestyramine, Colestipol, Orlistat, Mineral oil

May impair absorption of Vitamin D.

Storage

Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose (hypervitaminosis D) include hypercalcemia with nausea, vomiting, loss of appetite, constipation, weakness, fatigue, headache, muscle pain, and metallic taste. Severe cases can lead to kidney damage and cardiac arrhythmias. Treatment involves discontinuing the medicine, a low-calcium diet, increased fluid intake, and potentially corticosteroids or bisphosphonates.

Pregnancy & Lactation

Vitamin D is essential during pregnancy and lactation. However, excessive doses should be avoided. The recommended daily allowance (RDA) during pregnancy and lactation is 600 IU, but higher doses (up to 4000 IU/day) may be given under medical supervision to treat deficiency. Consult a doctor.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets per blister30 tablets per box60 tablets per bottle

Shelf Life

Typically 24-36 months from manufacturing date.

Availability

Pharmacies, drug stores

Approval Status

Approved by regulatory bodies (e.g., FDA, DGDA)

Patent Status

Generic/Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Extensive clinical trials have established the efficacy and safety of cholecalciferol in preventing and treating vitamin D deficiency and related conditions.

Lab Monitoring

Serum 25-hydroxyvitamin D levels
Serum calcium levels
Serum phosphate levels
Renal function tests (e.g., creatinine, BUN)

Doctor Notes

Assess baseline Vitamin D levels before initiating high-dose therapy.
Monitor serum calcium, phosphate, and 25(OH)D levels periodically, especially in patients with renal impairment or those on concomitant medications.
Educate patients on symptoms of hypercalcemia.

Patient Guidelines

Follow your doctor's instructions carefully regarding dosage and duration.
Do not exceed the recommended dose without medical supervision.
Inform your doctor about all other medications, supplements, and herbal products you are taking.
Report any symptoms of hypercalcemia (nausea, vomiting, constipation, increased urination, muscle weakness) immediately.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

D-2000 2000 IU Tablet is generally not expected to affect the ability to drive or operate machinery.

Lifestyle Advice

Include Vitamin D rich foods in your diet (fatty fish, fortified dairy).
Get moderate sun exposure (10-30 minutes, 2-3 times a week, depending on skin type and location) for natural Vitamin D synthesis, while protecting against sunburn.
Maintain a balanced diet and regular exercise.

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