Medicine Information

D-Fix

Name: D-Fix
Brand: D-Fix
Rating: 4.5 (117 reviews)

Capsule200 mgAntibiotics (3rd Generation Cephalosporins)ATC: J01DD08

Generic Name

Cefixime

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
d fix 200 mg capsule	৳ 35.00	৳ 210.00

Description

Overview of the medicine

D-Fix 200 mg capsule contains Cefixime, a third-generation cephalosporin antibiotic used to treat various bacterial infections.

Uses & Indications

Uncomplicated Urinary Tract Infections (UTIs)

Otitis Media (middle ear infection)

Pharyngitis and Tonsillitis (throat infections)

Acute Bronchitis and Acute Exacerbations of Chronic Bronchitis

Uncomplicated Gonorrhea (cervical/urethral)

Dosage

Adults

The usual adult dose is 400 mg daily, given as a single dose or in two divided doses (200 mg every 12 hours).

Elderly

No specific dose adjustment is generally required for elderly patients with normal renal function. Dose adjustment is necessary for elderly patients with renal impairment.

Renal_impairment

For creatinine clearance 21-60 mL/min, the dose should be reduced to 300 mg daily. For creatinine clearance <20 mL/min, the dose should be reduced to 200 mg daily.

How to Take

D-Fix capsules should be taken orally, with or without food. It is recommended to take it at the same time each day to maintain consistent drug levels.

Mechanism of Action

Cefixime exerts its bactericidal effect by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, which prevents the cross-linking of peptidoglycan chains essential for bacterial cell wall integrity, leading to cell lysis and bacterial death.

Pharmacokinetics

Onset

Peak plasma concentrations are achieved 2-6 hours after administration.

Excretion

Approximately 50% of the absorbed dose is excreted unchanged in the urine over 24 hours. The remainder is excreted by non-renal mechanisms, likely biliary excretion.

Half life

Average plasma half-life is 3 to 4 hours, which may be prolonged in renal impairment.

Absorption

Approximately 40-50% orally absorbed. Food slows absorption but does not significantly affect the extent of absorption.

Metabolism

Not extensively metabolized in the body. No active metabolites identified.

Side Effects

Contraindications

Known hypersensitivity to Cefixime or any other cephalosporin antibiotics.
History of severe hypersensitivity reactions to penicillin or other beta-lactam antibiotics.

Drug Interactions

Nifedipine

May increase Cefixime bioavailability.

Carbamazepine

Elevated carbamazepine levels have been reported when administered concomitantly with Cefixime. Therapeutic drug monitoring may be useful.

Oral contraceptives

Some cephalosporins may reduce the efficacy of oral contraceptives, although data for Cefixime is limited.

Warfarin and other anticoagulants

May increase prothrombin time (PT) with or without bleeding, so careful monitoring of coagulation parameters is advised.

Storage

Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities from the circulation by hemodialysis or peritoneal dialysis. Treatment should be supportive and symptomatic.

Pregnancy & Lactation

Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. Cefixime is excreted in small amounts in human breast milk. Caution should be exercised when Cefixime is administered to a nursing mother.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 capsules (1x10 blister pack)30 capsules (3x10 blister pack)

Shelf Life

Typically 24 to 36 months from the date of manufacture.

Availability

Pharmacies, hospitals, clinics

Approval Status

Approved (local and international regulatory bodies)

Patent Status

Off-patent (generic available)

Clinical Trials

Cefixime has undergone extensive clinical trials demonstrating its efficacy and safety for various bacterial infections. Ongoing research continues to explore its use in new indications and resistance patterns.

Lab Monitoring

Renal function tests (e.g., creatinine clearance) in patients with impaired renal function or on prolonged therapy.
Coagulation parameters (e.g., PT/INR) if co-administered with anticoagulants.
Liver function tests (rarely, in case of suspected hepatic injury).

Doctor Notes

Emphasize the importance of completing the full course of therapy to prevent antibiotic resistance.
Caution in patients with a history of penicillin allergy; cross-reactivity can occur.
Monitor renal function in elderly patients and those with pre-existing renal impairment.

Patient Guidelines

Complete the entire course of medication as prescribed, even if symptoms improve.
Do not save medication for future use or share it with others.
Report any severe or persistent side effects to your doctor immediately.

Missed Dose Advice

If a dose is missed, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to make up for a missed one.

Driving Precautions

Cefixime may cause dizziness in some individuals. Patients should be advised to exercise caution before driving or operating machinery until they are sure that Cefixime does not adversely affect their ability to perform such activities.