Medicine Information

D-Peridone

Name: D-Peridone
Brand: D-Peridone
Rating: 4.5 (117 reviews)

Tablet10 mgAntiemetic & ProkineticATC: A03FA03

Generic Name

Domperidone

Manufacturer

Generic Pharmaceutical Co.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
d peridone 10 mg tablet	৳ 2.00	৳ 20.00

Description

Overview of the medicine

D-peridone 10 mg tablet contains Domperidone, a dopamine antagonist used to treat nausea and vomiting, and to promote gastrointestinal motility.

Uses & Indications

Treatment of nausea and vomiting of various origins (e.g., drug-induced, post-operative, migraine-associated)

Symptomatic treatment of dyspepsia (e.g., bloating, fullness, epigastric pain)

Management of gastro-esophageal reflux disease (GERD) symptoms

Prevention of nausea and vomiting associated with levodopa and bromocriptine therapy

Dosage

Adults

10 mg three to four times daily, before meals and at bedtime. Maximum daily dose is 30 mg.

Elderly

No specific dose adjustment for elderly patients, but caution is advised due to potential for cardiac effects.

Renal_impairment

In severe renal impairment (creatinine clearance < 30 mL/min), frequency should be reduced to once or twice daily depending on severity. Cardiac risks should be monitored.

How to Take

Take orally, preferably 15-30 minutes before meals. Do not crush or chew the tablet; swallow whole with water.

Mechanism of Action

Domperidone acts as a peripheral dopamine D2 receptor antagonist, primarily blocking dopamine receptors in the chemoreceptor trigger zone (CTZ) located outside the blood-brain barrier. This action reduces nausea and vomiting. It also enhances gastrointestinal peristalsis by blocking dopamine receptors in the gut, promoting gastric emptying and intestinal transit.

Pharmacokinetics

Onset

30-60 minutes

Excretion

Approximately 60% via feces and 30% via urine, primarily as metabolites.

Half life

Approximately 7-9 hours (longer in severe renal impairment)

Absorption

Rapidly absorbed after oral administration, peak plasma concentration reached within 1 hour.

Metabolism

Extensively metabolized in the liver by CYP3A4 hydroxylation and N-dealkylation.

Side Effects

Contraindications

Known hypersensitivity to domperidone or any component of the formulation
Patients with moderate to severe hepatic impairment
Patients with cardiac conditions such as prolonged QT interval, significant electrolyte disturbances, or underlying heart disease
Coadministration with potent CYP3A4 inhibitors (e.g., ketoconazole, erythromycin)
Prolactinoma
Patients with gastrointestinal hemorrhage, mechanical obstruction, or perforation

Drug Interactions

Antacids and H2-receptor blockers

May decrease the oral bioavailability of domperidone. Take domperidone before meals and antacids after meals.

QT-prolonging drugs (e.g., Amiodarone, Cisapride, Fluoxetine)

Increased risk of QT prolongation and cardiac arrhythmias. Avoid concomitant use.

Potent CYP3A4 inhibitors (e.g., Ketoconazole, Erythromycin, Ritonavir)

Increased plasma levels of domperidone, increased risk of QT prolongation. Concomitant use is contraindicated.

Storage

Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose include drowsiness, disorientation, extrapyramidal reactions, and QT prolongation. Treatment is symptomatic and supportive, including gastric lavage and activated charcoal. ECG monitoring is recommended.

Pregnancy & Lactation

Pregnancy Category C. Use during pregnancy only if clearly needed and the potential benefits outweigh the potential risks. Domperidone is excreted in breast milk in small amounts; caution advised during lactation.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets30 tablets50 tablets

Shelf Life

24-36 months from manufacturing date

Availability

Pharmacies nationwide

Approval Status

Approved (DGDA)

Patent Status

Off-patent

Clinical Trials

Extensive clinical trials have established the efficacy and safety of domperidone in treating nausea, vomiting, and gastrointestinal motility disorders. Recent trials have focused on cardiac safety, leading to revised dosage recommendations.

Lab Monitoring

ECG monitoring for patients at risk of cardiac arrhythmias or those on high doses.
Electrolyte levels (Potassium, Magnesium) should be monitored, especially in patients with pre-existing conditions or on concomitant medications that can alter electrolyte balance.

Doctor Notes

Advise patients to report any cardiac symptoms (e.g., palpitations, fainting) immediately.
Assess patient's cardiac risk factors and concomitant medications before prescribing.
Use with caution in patients with renal impairment; dose adjustment may be necessary.

Patient Guidelines

Take this medicine exactly as prescribed by your doctor.
Do not exceed the recommended dose or duration of treatment.
Inform your doctor about all other medications you are taking, especially heart medications or antifungals.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it's almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.