Medicine Information

Daflon

Name: Daflon
Brand: Daflon
Rating: 4.5 (117 reviews)

Tablet450 mg (total flavonoid fraction)Venotonics, VasoprotectivesATC: C05CA53

Generic Name

Micronized Purified Flavonoid Fraction (405 mg Diosmin and 45 mg Hesperidin)

Manufacturer

Les Laboratoires Servier (original brand)

Country

France (original)

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
daflon 450 mg tablet	৳ 16.00	৳ 240.00

Description

Overview of the medicine

Daflon 450 mg is a venotonic and vasoprotective agent used to treat venous insufficiency (e.g., heavy legs, pain, nocturnal cramps, edema) and hemorrhoids (acute and chronic). It is a micronized purified flavonoid fraction composed of 405 mg Diosmin and 45 mg Hesperidin.

Uses & Indications

Treatment of symptoms related to venolymphatic insufficiency (heavy legs, pain, nocturnal cramps, edema).

Treatment of acute hemorrhoidal attacks.

Treatment of chronic hemorrhoidal disease.

Dosage

Adults

Venolymphatic insufficiency: 1 tablet twice daily, morning and evening, with meals. Acute hemorrhoidal attacks: 3 tablets twice daily for the first 4 days, then 2 tablets twice daily for the next 3 days, with meals. Chronic hemorrhoidal disease: 1 tablet twice daily with meals.

Elderly

No specific dose adjustment is generally required for elderly patients, but use with caution and monitor for side effects.

Renal_impairment

No specific dosage adjustment guidelines are available; however, use with caution in patients with severe renal impairment due to limited excretion data.

How to Take

Oral administration. Tablets should be taken with meals.

Mechanism of Action

Daflon enhances venous tone by prolonging noradrenaline activity on venous walls, reducing venous distensibility and stasis. It also reduces capillary hyperpermeability and increases lymphatic drainage, leading to a reduction in edema and inflammation.

Pharmacokinetics

Onset

Clinical effects may be observed within a few days to weeks depending on the indication.

Excretion

Mainly through feces (about 80%), and a small percentage (about 14%) via urine.

Half life

Approximately 11 hours (for diosmin, after metabolism).

Absorption

Rapidly absorbed after oral administration. Extensive metabolism leads to phenolic acids which are eliminated.

Metabolism

Extensively metabolized in the liver to phenolic acids, predominantly m-hydroxyphenylpropionic acid.

Side Effects

Contraindications

Hypersensitivity to the active substance or to any of the excipients.

Drug Interactions

Anticoagulants (e.g., Warfarin)

Theoretical risk of increased bleeding due to potential effect on platelet aggregation. Monitor INR if co-administered.

Storage

Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.

Overdose

Limited data on overdose. Symptoms typically include gastrointestinal disturbances (diarrhea, nausea, abdominal pain) and skin reactions (rash, pruritus). Treatment is symptomatic.

Pregnancy & Lactation

Pregnancy: Studies in animals have not shown teratogenic effects. Limited human data suggest no adverse effects. Use during pregnancy only if clearly needed and under medical supervision. Lactation: It is not known whether the active substance is excreted in human milk. A decision must be made whether to discontinue breastfeeding or to discontinue/abstain from Daflon therapy.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

Blister pack of 10 tabletsBox of 30 tabletsBox of 60 tablets

Shelf Life

Usually 2-3 years from the date of manufacture.

Availability

Available in pharmacies, hospitals, and clinics

Approval Status

Globally approved in many countries (e.g., France, Bangladesh)

Patent Status

Off-patent (generic versions available)

Clinical Trials

Numerous clinical trials have demonstrated the efficacy and safety of Micronized Purified Flavonoid Fraction (MPFF) in the management of chronic venous disease and hemorrhoids.

Lab Monitoring

Routine lab monitoring is not typically required with Daflon 450 mg.

Doctor Notes

Educate patients on the importance of lifestyle modifications alongside medication for optimal management of venous disease.
Reassure patients that gastrointestinal side effects are usually mild and transient.

Patient Guidelines

Follow your doctor's instructions regarding dosage and duration of treatment.
Take tablets with meals to minimize gastrointestinal discomfort.
Inform your doctor if you experience any unusual or severe side effects.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

No known effects on the ability to drive or operate machinery. However, if you experience dizziness or malaise, avoid such activities.

Lifestyle Advice

For venous insufficiency: Elevate your legs, avoid prolonged standing, wear compression stockings, and engage in regular physical activity.
For hemorrhoids: Maintain a high-fiber diet, drink plenty of fluids, and avoid straining during bowel movements.