Medicine Information

Debion

Name: Debion
Brand: Debion
Rating: 4.5 (117 reviews)

Tablet100 mgVitamin B1 preparationsATC: A11DA01

Generic Name

Thiamine Hydrochloride

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
debion 100 mg tablet	৳ 7.00	৳ 70.00

Description

Overview of the medicine

Debion-100 mg Tablet contains Thiamine Hydrochloride, a water-soluble vitamin (B1), essential for carbohydrate metabolism and nerve function. It is used to prevent and treat Thiamine deficiency.

Uses & Indications

Treatment and prevention of Thiamine deficiency (Beriberi)

Wernicke's encephalopathy

Peripheral neuritis due to alcoholism or pregnancy

Support in conditions with increased metabolic demand (e.g., fever, hyperthyroidism)

Dietary supplement

Dosage

Adults

For deficiency, 10-100 mg daily. For severe deficiency (Wernicke-Korsakoff syndrome), higher doses may be given parenterally under medical supervision.

Elderly

No specific dose adjustment generally required, but caution with polypharmacy and renal/hepatic impairment.

Renal_impairment

No specific dose adjustment recommended, as it is primarily excreted renally and considered safe.

How to Take

Oral. Can be taken with or without food. Swallow the tablet whole with water.

Mechanism of Action

Thiamine is converted to thiamine pyrophosphate (TPP), a coenzyme for several metabolic enzymes, including pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase, crucial for carbohydrate metabolism and energy production.

Pharmacokinetics

Onset

Rapid, effects seen within hours to days depending on severity of deficiency.

Excretion

Excreted primarily in the urine as inactive metabolites or unchanged thiamine, especially after high doses.

Half life

Approximately 9-18 days in humans (for TPP).

Absorption

Well absorbed from the gastrointestinal tract, primarily in the duodenum, through an active transport mechanism at lower concentrations and passive diffusion at higher concentrations.

Metabolism

Metabolized in the liver to active thiamine pyrophosphate (TPP) and other inactive metabolites.

Side Effects

Contraindications

Hypersensitivity to thiamine or any component of the formulation.

Drug Interactions

Fluorouracil

May inhibit thiamine phosphorylation, potentially leading to thiamine deficiency when co-administered.

Oral Contraceptives

Some studies suggest long-term use might slightly increase thiamine requirements, but clinical significance is usually minimal.

Thiaminase-containing foods

Consumption of large amounts of raw fish, shellfish, tea, and coffee may interfere with thiamine absorption or increase its degradation.

Storage

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.

Overdose

Thiamine is water-soluble, and excessive amounts are generally excreted in urine. Overdose is rare with oral administration and usually causes no significant adverse effects. Very high parenteral doses might rarely cause flushing, weakness, peripheral vasodilation, and anaphylaxis.

Pregnancy & Lactation

Generally considered safe and often recommended as part of prenatal vitamins. Thiamine is excreted in breast milk in small amounts; safe for nursing mothers at recommended doses.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 x 10 tablets (blister pack)30 tablets (bottle)

Shelf Life

Typically 2-3 years from the date of manufacture.

Availability

Pharmacies, drug stores

Approval Status

Approved by regulatory authorities

Patent Status

Expired

WHO Essential Medicine

Yes

Clinical Trials

Extensive historical data supports the efficacy of Thiamine. Modern clinical trials often focus on specific patient populations with deficiencies (e.g., alcoholics, bariatric surgery patients) or exploring new formulations and delivery methods.

Lab Monitoring

Thiamine levels in blood (for diagnosis of deficiency)
Erythrocyte transketolase activity (functional test for thiamine status)

Doctor Notes

Crucial for patients with chronic alcoholism, malabsorption syndromes (e.g., Crohn's disease, celiac disease), or post-bariatric surgery.
In suspected Wernicke's encephalopathy, administer thiamine before glucose infusion to prevent worsening of neurological symptoms.
Patients undergoing hemodialysis may require increased thiamine supplementation.

Patient Guidelines

Take as directed by your healthcare provider, typically once daily.
Do not exceed the recommended dose without consulting a doctor.
Store at room temperature, away from moisture and direct heat, and out of reach of children.

Missed Dose Advice

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double dose to make up for a missed one.

Driving Precautions

No specific precautions are generally needed as Debion-100 mg Tablet does not typically impair driving ability or operating machinery.

Lifestyle Advice

Maintain a balanced diet rich in thiamine (found in whole grains, meat, legumes, nuts, and yeast).
Limit alcohol intake, especially if you have a thiamine deficiency or are at risk.