Decabutamol
Generic Name
Decabutamol 2 mg Syrup
Manufacturer
MediCorp Pharmaceuticals
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| decabutamol 2 mg syrup | ৳ 21.83 | N/A |
Description
Overview of the medicine
Decabutamol syrup is a bronchodilator used to relieve symptoms of asthma, chronic obstructive pulmonary disease (COPD), and other reversible obstructive airway diseases.
Uses & Indications
Dosage
Adults
2-4 mg (5-10 ml) three to four times daily. Maximum daily dose should not exceed 32 mg.
Elderly
Start with a lower dose, e.g., 2 mg (5 ml) three times daily, and adjust according to response and tolerability.
Renal_impairment
No specific dosage adjustment is usually required, but monitor for adverse effects, especially with high doses.
How to Take
Decabutamol syrup is for oral administration. It can be taken with or without food. Use the provided measuring cup or spoon for accurate dosing. Shake the bottle well before use.
Mechanism of Action
Decabutamol selectively stimulates beta-2 adrenergic receptors in bronchial smooth muscle, leading to relaxation of the muscle and subsequent bronchodilation. This helps to open the airways and improve breathing.
Pharmacokinetics
Onset
Bronchodilatory effect typically begins within 5-15 minutes.
Excretion
Excreted mainly via urine as metabolites and unchanged drug, with a small portion excreted in feces.
Half life
Plasma half-life ranges from 3 to 6 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract following oral administration, with peak plasma concentrations achieved within 1-2 hours.
Metabolism
Primarily metabolized in the liver by conjugation to inactive sulfate metabolites.
Side Effects
Contraindications
- Hypersensitivity to decabutamol, other sympathomimetics, or any excipients of the syrup.
- Patients with pre-existing severe cardiac arrhythmias, uncontrolled hypertension, or ischemic heart disease.
Drug Interactions
Diuretics
Concomitant use with potassium-depleting diuretics (e.g., loop or thiazide diuretics) may increase the risk of hypokalemia.
Beta-blockers
Non-selective beta-blockers may antagonize the bronchodilatory effect of decabutamol and should generally be avoided. Cardioselective beta-blockers should be used with caution.
Other sympathomimetics
Concomitant use may lead to additive cardiovascular effects.
Tricyclic antidepressants and MAO inhibitors
May potentiate the cardiovascular effects of decabutamol, increasing the risk of arrhythmias and hypertension.
Storage
Store below 30°C in a dry place, protected from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Symptoms of overdose include tachycardia, tremor, headache, palpitations, hypokalemia, and hyperglycemia. In severe cases, cardiac arrest and death may occur. Treatment is symptomatic and supportive, including discontinuing the drug, monitoring vital signs, and correcting electrolyte imbalances.
Pregnancy & Lactation
Decabutamol should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is unknown if decabutamol is excreted in human milk. Exercise caution when administered to a nursing mother. Always consult a doctor before use during pregnancy or lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the manufacturing date.
Availability
Pharmacies and hospitals nationwide
Approval Status
Approved by health authorities
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Clinical trials for Decabutamol demonstrated its efficacy and safety in improving lung function and reducing symptoms in patients with asthma and COPD. Further post-marketing surveillance continues to monitor long-term outcomes.
Lab Monitoring
- Serum potassium levels (especially in patients receiving high doses, concomitant diuretics, or corticosteroids)
Doctor Notes
- Emphasize the importance of patient education regarding the proper use of the syrup and recognition of worsening symptoms.
- Monitor for cardiac side effects, especially in patients with pre-existing cardiovascular conditions or those receiving high doses.
- Advise patients not to use this medication as a substitute for inhaled corticosteroids in chronic asthma management.
Patient Guidelines
- Do not exceed the prescribed dose or frequency of use.
- If your symptoms worsen or you need to use this medicine more often than usual, consult your doctor immediately.
- Inform your doctor or pharmacist about all other medications, including over-the-counter drugs and herbal supplements, you are currently taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Decabutamol may cause side effects such as tremor, dizziness, or nervousness in some patients, which could impair the ability to drive or operate machinery. Exercise caution until you know how the medicine affects you.
Lifestyle Advice
- Avoid smoking as it can worsen respiratory conditions and reduce the effectiveness of bronchodilators.
- Maintain a healthy lifestyle, including a balanced diet and regular exercise, as tolerated.
- Identify and avoid triggers that may worsen your asthma or COPD symptoms.
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Global Brand Names
International brand names for this medicine
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