Medicine Information

Demax

Name: Demax
Brand: Demax
Rating: 4.5 (117 reviews)

Tablet0.5 mgAnxiolytics, Sedatives & HypnoticsATC: N03AE01

Generic Name

Clonazepam

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

Loading images...

Price Details

Current market pricing information

Variant	Unit Price	Strip Price
demax 05 mg tablet	৳ 1.00	N/A

Description

Overview of the medicine

Demax 0.5 mg tablet contains Clonazepam, a benzodiazepine, used to treat anxiety disorders, panic disorder, and certain types of seizures. It works by enhancing the activity of a neurotransmitter called gamma-aminobutyric acid (GABA) in the brain.

Uses & Indications

Panic disorder (with or without agoraphobia)

Certain seizure disorders (Lennox-Gastaut syndrome, akinetic and myoclonic seizures)

Anxiety disorders (off-label)

Dosage

Adults

Initial dose for panic disorder: 0.25 mg twice daily; may increase to 1 mg/day after 3 days. For seizure disorders: Initial dose 0.5 mg three times daily, gradually increased by 0.5-1 mg every 3 days until seizure control is achieved (maximum 20 mg/day).

Elderly

Lower doses are recommended due to increased sensitivity and risk of adverse effects. Initial dose of 0.125 mg once or twice daily.

Renal_impairment

No specific dosage adjustment guidelines for renal impairment; use with caution.

How to Take

Take orally with or without food. Swallow the tablet whole with water. Do not crush or chew.

Mechanism of Action

Clonazepam enhances the effect of gamma-aminobutyric acid (GABA) at GABA-A receptors, leading to increased chloride ion influx into neurons, hyperpolarization, and reduced neuronal excitability in the central nervous system.

Pharmacokinetics

Onset

30-60 minutes

Excretion

Mainly excreted in the urine as metabolites, with a small amount excreted in feces.

Half life

18-50 hours (average 30-40 hours)

Absorption

Rapidly and completely absorbed after oral administration. Peak plasma concentrations are reached within 1-4 hours.

Metabolism

Primarily metabolized in the liver by nitroreduction to 7-aminoclonazepam and by N-acetylation.

Side Effects

Contraindications

Acute narrow-angle glaucoma
Severe liver disease
Known hypersensitivity to clonazepam or other benzodiazepines

Drug Interactions

Opioids

Increased risk of respiratory depression, sedation, and coma.

Alcohol and CNS depressants

Increased sedative effects.

Antifungal agents (e.g., ketoconazole)

May increase clonazepam plasma levels.

CYP3A4 inducers (e.g., carbamazepine, phenytoin)

May decrease clonazepam plasma levels.

Storage

Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

Symptoms include drowsiness, confusion, impaired coordination, diminished reflexes, and coma. Management involves supportive care, maintaining a patent airway, and if appropriate, flumazenil (a benzodiazepine antagonist) under strict medical supervision.

Pregnancy & Lactation

Pregnancy Category D. May cause fetal harm. Avoid during pregnancy unless benefits outweigh risks. Excreted in breast milk, not recommended during lactation.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets per blister30 tablets per box

Shelf Life

Usually 24-36 months from manufacturing date.

Availability

Available in pharmacies nationwide

Approval Status

Approved by FDA and DGDA (for generic Clonazepam)

Patent Status

Generic available (patent expired for Clonazepam)

WHO Essential Medicine

Yes

Clinical Trials

Extensive clinical trials have established clonazepam's efficacy and safety in various neurological and psychiatric conditions. Ongoing research explores its long-term effects and potential new indications.

Lab Monitoring

Liver function tests (periodically, especially with long-term use)
Complete blood count (periodically)

Doctor Notes

Advise patients about the risk of dependence and withdrawal. Emphasize gradual tapering when discontinuing.
Monitor for signs of depression or suicidal ideation, especially during initial treatment or dose adjustments.
Assess for concurrent use of opioids or alcohol and counsel on risks.

Patient Guidelines

Do not stop taking this medicine suddenly, as it can cause withdrawal symptoms.
Avoid alcohol and other CNS depressants.
Report any unusual mood or behavior changes to your doctor.
Do not drive or operate heavy machinery until you know how this medicine affects you.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

May cause drowsiness, dizziness, and impaired coordination. Avoid driving or operating machinery until you are certain the drug does not impair your ability.