Medicine Information

Deprolin

Name: Deprolin
Brand: Deprolin
Rating: 4.5 (117 reviews)

Syrup20 mg/5 mlAntidepressantATC: N06AB03

Generic Name

Fluoxetine 20 mg/5 ml syrup

Manufacturer

MediCorp Pharma Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
deprolin 20 mg syrup	৳ 110.00	N/A

Description

Overview of the medicine

Deprolin 20 mg syrup contains Fluoxetine, a selective serotonin reuptake inhibitor (SSRI) used to treat major depressive disorder, obsessive-compulsive disorder, panic disorder, and bulimia nervosa. It helps restore the balance of serotonin in the brain.

Uses & Indications

Major Depressive Disorder (MDD)

Obsessive-Compulsive Disorder (OCD)

Bulimia Nervosa

Panic Disorder (with or without agoraphobia)

Dosage

Adults

Major Depressive Disorder: Initially 20 mg once daily, may be increased after several weeks to a maximum of 80 mg/day. OCD: Initially 20 mg once daily, typically 20-60 mg/day.

Elderly

Lower initial doses (e.g., 10 mg/day) may be considered, with gradual titration. Maximum recommended dose generally lower.

Renal_impairment

No dosage adjustment necessary for mild to moderate impairment. Use with caution in severe impairment; consider lower frequency/dose.

How to Take

Take orally, with or without food, usually once daily in the morning. For children, the syrup can be mixed with a small amount of water or juice if needed.

Mechanism of Action

Fluoxetine selectively inhibits the reuptake of serotonin by neurons in the central nervous system, thereby increasing the concentration of serotonin in the synaptic cleft and enhancing serotonergic neurotransmission.

Pharmacokinetics

Onset

Initial antidepressant effects may be seen within 1-2 weeks, but full therapeutic effect usually takes 4-5 weeks.

Excretion

Primarily excreted renally (about 60%) as metabolites, with a small amount excreted in feces.

Half life

Parent drug: 4-6 days; Active metabolite (norfluoxetine): 4-16 days.

Absorption

Well absorbed orally; peak plasma concentrations reached in 6-8 hours.

Metabolism

Extensively metabolized in the liver by CYP2D6 to its active metabolite, norfluoxetine.

Side Effects

Contraindications

Hypersensitivity to Fluoxetine or any component of the syrup
Concurrent use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of discontinuing an MAOI
Concurrent use with Thioridazine or Pimozide

Drug Interactions

MAOIs

Risk of serotonin syndrome, may be fatal. Avoid concurrent use.

Warfarin/Anticoagulants

Increased risk of bleeding.

Drugs metabolized by CYP2D6 (e.g., TCAs, Flecainide)

Fluoxetine can inhibit CYP2D6, increasing levels of co-administered drugs.

Other Serotonergic Drugs (e.g., Triptans, Tramadol, other SSRIs)

Increased risk of serotonin syndrome.

Storage

Store below 30°C, protected from light and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose include nausea, vomiting, seizures, cardiovascular dysfunction, and serotonin syndrome. Treatment is symptomatic and supportive; maintain airway, monitor cardiac and vital signs. Activated charcoal may be considered.

Pregnancy & Lactation

Pregnancy Category C. Use only if potential benefit justifies the potential risk to the fetus. Fluoxetine is excreted in breast milk; avoid use during breastfeeding or monitor infant for adverse effects.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

60 ml syrup bottle100 ml syrup bottle

Shelf Life

Typically 24 to 36 months from the date of manufacture.

Availability

Available in pharmacies, hospitals, and clinics

Approval Status

Approved by DGDA/FDA

Patent Status

Patent expired, available as generic

WHO Essential Medicine

Yes

Clinical Trials

Fluoxetine has undergone extensive clinical trials for its approved indications, demonstrating efficacy and safety. Ongoing research continues to explore its use in other conditions.

Lab Monitoring

Monitor serum sodium levels periodically, especially in elderly or dehydrated patients.
Liver function tests if there is a history of hepatic impairment.

Doctor Notes

Monitor patients, especially pediatric and young adult patients, for worsening depression or the emergence of suicidal ideation and unusual behavioral changes.
Be vigilant for symptoms of serotonin syndrome, especially when co-administered with other serotonergic agents.

Patient Guidelines

Take exactly as prescribed, do not stop abruptly without consulting your doctor.
It may take several weeks to feel the full benefits of the medication.
Report any unusual mood or behavior changes, especially suicidal thoughts, to your doctor immediately.

Missed Dose Advice

If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not double the dose.