Medicine Information

Dersole

Name: Dersole
Brand: Dersole
Rating: 4.5 (117 reviews)

Ointment0.05% w/wTopical CorticosteroidsATC: D07AD01

Generic Name

Clobetasol Propionate 0.05% Ointment

Manufacturer

Healthcare Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
dersole 005 ointment	৳ 50.14	N/A

Description

Overview of the medicine

Dersole-005 Ointment is a potent topical corticosteroid containing Clobetasol Propionate 0.05%. It is used for the short-term treatment of inflammatory skin conditions such as severe eczema, psoriasis, and other dermatoses that respond to steroids, when less potent corticosteroids have been ineffective.

Uses & Indications

Severe recalcitrant eczemas

Psoriasis (excluding widespread plaque psoriasis)

Lichen planus

Discoid lupus erythematosus

Other dermatoses unresponsive to less potent corticosteroids

Dosage

Adults

Apply a thin film to the affected skin area once or twice daily. Do not use for more than 4 consecutive weeks. Treatment should be limited to short courses and small areas.

Elderly

No specific dosage adjustment is generally required, but caution is advised due to potential for increased systemic absorption and thinner skin.

Renal_impairment

No specific dosage adjustment is generally required for topical use, but systemic absorption should be monitored if used extensively.

How to Take

Apply a small amount of ointment to the affected skin area and gently rub it in until it disappears. Wash hands immediately after application, unless hands are the treated area. Do not use occlusive dressings unless specifically advised by a doctor.

Mechanism of Action

Clobetasol Propionate is a highly potent corticosteroid that exhibits anti-inflammatory, antipruritic, and vasoconstrictive actions. It acts by inducing phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid.

Pharmacokinetics

Onset

Symptomatic relief can occur within a few days of consistent application.

Excretion

Excreted primarily by the kidneys, and to a lesser extent, via bile.

Half life

Not well-defined for topical application; depends on systemic absorption and metabolism.

Absorption

Systemic absorption of topical corticosteroids can occur, especially through compromised skin, prolonged use, or with occlusive dressings. Absorption is higher in areas with thin skin, like the face and genitals.

Metabolism

Once absorbed, clobetasol propionate is primarily metabolized in the liver to inactive metabolites.

Side Effects

Contraindications

Hypersensitivity to Clobetasol Propionate or any other component of the preparation
Rosacea
Acne vulgaris
Perioral dermatitis
Pruritus without inflammation
Perianal and genital pruritus
Primary cutaneous viral infections (e.g., herpes simplex, chickenpox)
Fungal infections (e.g., candidiasis, tinea)
Bacterial infections (e.g., impetigo)
Children under 12 years of age for long-term use

Drug Interactions

CYP3A4 Inhibitors (e.g., Ritonavir, Itraconazole)

May increase systemic exposure to Clobetasol, leading to an increased risk of systemic side effects. Concomitant use should be undertaken with caution.

Storage

Store below 30°C. Protect from light and moisture. Do not freeze. Keep out of reach of children.

Overdose

Acute overdose with topical corticosteroids is unlikely. In the event of chronic overdose or misuse, symptoms of hypercorticism (e.g., Cushing's syndrome) may appear due to systemic absorption. Treatment should be gradual withdrawal of the steroid, under medical supervision.

Pregnancy & Lactation

Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether topical administration of corticosteroids can result in sufficient systemic absorption to produce detectable quantities in breast milk. Use with caution in nursing mothers.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 gm tube15 gm tube

Shelf Life

Typically 24 to 36 months from manufacturing date.

Availability

Available in pharmacies and hospitals

Approval Status

Approved by regulatory authorities

Patent Status

Off-patent

Clinical Trials

Clobetasol Propionate has been extensively studied in numerous clinical trials demonstrating its efficacy and safety for various steroid-responsive dermatoses.

Lab Monitoring

Adrenal function tests (e.g., plasma cortisol levels) may be considered if extensive use or HPA axis suppression is suspected, especially in pediatric patients.

Doctor Notes

Emphasize short-term use (max 4 weeks) and avoidance on sensitive areas like the face.
Educate patients on potential for systemic absorption and adrenal suppression, especially in pediatric patients.
Monitor for signs of local skin reactions and systemic side effects.

Patient Guidelines

Apply sparingly and thinly to the affected area.
Do not use for longer than the prescribed period (usually 2-4 weeks).
Avoid application to the face, groin, or axillae unless specifically directed by a doctor.
Wash hands after application.
Do not cover the treated area with occlusive dressings unless advised by a doctor.
Keep out of reach of children.

Missed Dose Advice

If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not apply extra medicine to make up for a missed dose.