Medicine Information

Desolet

Name: Desolet
Brand: Desolet
Rating: 4.5 (117 reviews)

Tablet5 mgAntihistaminesATC: R06AX27

Generic Name

Desloratadine

Manufacturer

Popular Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
desolet 5 mg tablet	৳ 2.50	N/A

Description

Overview of the medicine

Desolet 5 mg Tablet contains Desloratadine, a non-drowsy antihistamine used to relieve allergy symptoms such as sneezing, runny nose, itchy eyes, and hives.

Uses & Indications

Relief of symptoms associated with seasonal allergic rhinitis (hay fever)

Relief of symptoms associated with perennial allergic rhinitis

Relief of symptoms associated with chronic idiopathic urticaria (hives)

Dosage

Adults

One 5 mg tablet once daily.

Elderly

No dosage adjustment typically required, but caution is advised in those with renal or hepatic impairment.

Renal_impairment

For patients with severe renal impairment, a reduced frequency (e.g., one tablet every other day) may be considered.

How to Take

Oral administration. May be taken with or without food.

Mechanism of Action

Desloratadine is a long-acting tricyclic histamine antagonist with selective H1-receptor antagonist activity. It prevents histamine from binding to H1 receptors, thereby alleviating allergic symptoms.

Pharmacokinetics

Onset

Within 1 hour

Excretion

Eliminated primarily via urine and feces as metabolites.

Half life

Approximately 27 hours

Absorption

Rapidly absorbed after oral administration, peak plasma concentrations achieved in approximately 3 hours.

Metabolism

Undergoes extensive metabolism via hydroxylation to 3-hydroxydesloratadine, which is then glucuronidated.

Side Effects

Contraindications

Hypersensitivity to Desloratadine, Loratadine, or any component of the formulation.
History of allergic reaction to Desloratadine.

Drug Interactions

Cimetidine

May increase plasma concentrations of Desloratadine.

Fluoxetine

May increase plasma concentrations of Desloratadine.

Azithromycin

No clinically significant interaction expected.

Erythromycin

May increase plasma concentrations of Desloratadine.

Ketoconazole

May increase plasma concentrations of Desloratadine.

Storage

Store below 30°C, protect from light and moisture.

Overdose

Symptoms of overdose may include drowsiness, tachycardia, and headache. Treatment is symptomatic and supportive. Gastric lavage and activated charcoal may be considered.

Pregnancy & Lactation

Use during pregnancy only if clearly needed. Desloratadine is excreted in breast milk; therefore, a decision should be made whether to discontinue nursing or to discontinue the drug.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets30 tablets

Shelf Life

24 months

Availability

Pharmacies, Hospitals

Approval Status

Approved by health authorities

Patent Status

Generic available

Clinical Trials

Various clinical trials have demonstrated Desloratadine's efficacy and safety in treating allergic rhinitis and chronic idiopathic urticaria.

Lab Monitoring

No routine lab monitoring required. Liver and kidney function tests may be considered in patients with pre-existing impairment.

Doctor Notes

Advise patients to take consistently.
Monitor for symptom improvement.
Educate on potential for mild drowsiness, though rare.

Patient Guidelines

Take exactly as prescribed.
Do not exceed the recommended dose.
Inform your doctor about all other medications you are taking.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.