Medicine Information

Dexlazo

Name: Dexlazo
Brand: Dexlazo
Rating: 4.5 (117 reviews)

Capsule30 mgProton Pump Inhibitor (PPI)ATC: A02BC06

Generic Name

Dexlansoprazole

Manufacturer

Incepta Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
dexlazo 30 mg capsule	৳ 9.00	৳ 90.00

Description

Overview of the medicine

Dexlazo (Dexlansoprazole) is a proton pump inhibitor (PPI) used to treat symptoms of gastroesophageal reflux disease (GERD), heal erosive esophagitis (EE), and maintain healing of EE.

Uses & Indications

Healing of all grades of erosive esophagitis (EE) for up to 8 weeks.

Maintenance of healed erosive esophagitis and relief of heartburn for up to 6 months.

Treatment of symptomatic non-erosive gastroesophageal reflux disease (GERD) for 4 weeks.

Dosage

Adults

For healing EE: 60 mg once daily for up to 8 weeks. For maintenance of healed EE and relief of heartburn: 30 mg once daily. For symptomatic GERD: 30 mg once daily for 4 weeks.

Elderly

No dosage adjustment is generally required. However, monitor for potential adverse effects.

Renal_impairment

No dosage adjustment is necessary for patients with renal impairment.

How to Take

Take orally, with or without food. Swallow the capsule whole; do not chew, crush, or open the capsule.

Mechanism of Action

Dexlansoprazole suppresses gastric acid secretion by irreversibly inhibiting the H+/K+-ATPase enzyme system at the secretory surface of the gastric parietal cell, thereby blocking the final step of acid production.

Pharmacokinetics

Onset

Within 2-3 hours

Excretion

Primarily excreted via urine (approximately 50%) and feces (approximately 23%) as inactive metabolites.

Half life

Approximately 1-2 hours (terminal elimination half-life)

Absorption

Rapidly absorbed after oral administration with two distinct peaks due to the dual delayed release formulation. Absolute bioavailability is approximately 75%.

Metabolism

Extensively metabolized in the liver by cytochrome P450 (CYP) enzymes, primarily CYP2C19 and CYP3A4, to inactive hydroxylated and sulfated metabolites.

Side Effects

Contraindications

Known hypersensitivity to dexlansoprazole or any component of the formulation.
Coadministration with products containing rilpivirine.

Drug Interactions

Digoxin

Increased digoxin absorption and levels.

Warfarin

Increased INR and prothrombin time, monitor carefully.

Iron Salts

Decreased absorption of iron salts.

Clopidogrel

Reduced effectiveness of clopidogrel due to CYP2C19 inhibition.

Methotrexate

Possible increased methotrexate levels, especially with high doses.

Storage

Store in a cool and dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

In case of overdose, seek immediate medical attention. Management should be symptomatic and supportive. Dexlansoprazole is not readily dialyzable.

Pregnancy & Lactation

Pregnancy Category B. Should be used during pregnancy only if clearly needed. Excretion into breast milk is unknown; caution should be exercised when administered to a nursing woman.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 capsules per box30 capsules per box

Shelf Life

24 months from manufacturing date.

Availability

Pharmacies, Hospitals

Approval Status

FDA Approved

Patent Status

Patent Expired (for active ingredient)

Clinical Trials

Extensive clinical trials have demonstrated the efficacy and safety of dexlansoprazole in the healing and maintenance of erosive esophagitis and in the treatment of symptomatic GERD.

Lab Monitoring

Monitor INR and prothrombin time in patients concomitantly receiving warfarin.
Monitor serum magnesium levels periodically in patients expected to be on prolonged treatment (≥3 months) or concomitantly receiving other medications that can cause hypomagnesemia (e.g., diuretics).

Doctor Notes

Counsel patients on appropriate use and potential long-term risks of PPIs.
Consider magnesium level monitoring for patients on prolonged therapy or concomitant diuretics.
Review the need for continued PPI therapy periodically, especially for GERD without erosive esophagitis.
Be aware of potential drug interactions, particularly with warfarin, clopidogrel, and methotrexate.

Patient Guidelines

Take the medication exactly as prescribed by your doctor.
Do not stop taking Dexlazo suddenly without consulting your healthcare provider.
Report any new or worsening symptoms, or any unusual side effects to your doctor.
Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.

Missed Dose Advice

If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

This medicine may cause dizziness or visual disturbances. If you experience these effects, avoid driving or operating machinery.

Lifestyle Advice

Avoid foods and beverages that may worsen acid reflux, such as spicy foods, fatty foods, caffeine, alcohol, and carbonated drinks.
Eat smaller, more frequent meals instead of large ones.
Avoid lying down within 3 hours after eating.
Elevate the head of your bed by 6-8 inches.