Medicine Information

Dexon-G

Name: Dexon-G
Brand: Dexon-G
Rating: 4.5 (117 reviews)

Eye DropDexamethasone 0.1% + Gentamicin 0.3%Corticosteroid and Anti-infective (Ophthalmic)ATC: S01CA01

Generic Name

Dexamethasone and Gentamicin Eye Drop

Manufacturer

Incepta Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
dexon g 03 01 eye drop	৳ 120.00	N/A

Description

Overview of the medicine

Dexon-G Eye Drop is a combination medication containing Dexamethasone, a corticosteroid, and Gentamicin, an aminoglycoside antibiotic. It is used to treat inflammatory eye conditions where there is a risk of bacterial infection or where a bacterial infection is already present.

Uses & Indications

Steroid-responsive inflammatory ocular conditions where a bacterial infection or a risk of bacterial ocular infection exists.

Chronic anterior uveitis.

Corneal injury from chemical, radiation, or thermal burns, or penetration of foreign bodies.

Post-operative inflammation following ocular surgery.

Dosage

Adults

Instill 1 to 2 drops into the conjunctival sac of the affected eye(s) 3 to 4 times daily, or as directed by a physician. In severe cases, dosage may be increased to 2 drops every hour until improvement, then tapered.

Elderly

No specific dosage adjustment is generally required for elderly patients; use with caution.

Renal_impairment

No specific dosage adjustment for topical ophthalmic use, as systemic absorption is minimal.

How to Take

For ophthalmic use only. Wash hands thoroughly before use. Tilt head back, pull down the lower eyelid to form a pouch, instill the prescribed number of drops into the conjunctival sac, and gently close the eye. Do not touch the dropper tip to any surface.

Mechanism of Action

Dexamethasone acts as a potent anti-inflammatory corticosteroid by inhibiting the release of inflammatory mediators. Gentamicin is an aminoglycoside antibiotic that kills susceptible bacteria by inhibiting bacterial protein synthesis.

Pharmacokinetics

Onset

Anti-inflammatory effects can be observed within minutes to hours; antibacterial effects develop as therapeutic concentrations are reached.

Excretion

Systemically absorbed Dexamethasone is excreted renally; Gentamicin is excreted unchanged in urine.

Half life

Systemic half-life not clinically relevant for topical ophthalmic use.

Absorption

Minimal systemic absorption after topical ocular administration. Primarily exerts local effects.

Metabolism

Topically applied Dexamethasone is metabolized in the liver; Gentamicin is not significantly metabolized.

Side Effects

Contraindications

Hypersensitivity to Dexamethasone, Gentamicin, or any component of the formulation.
Acute untreated purulent bacterial infections of the eye.
Fungal diseases of ocular structures.
Vaccinia, varicella, and most other viral diseases of the cornea and conjunctiva, especially herpes simplex keratitis.
Mycobacterial infections of the eye.

Drug Interactions

Systemic Aminoglycosides

Concurrent use of systemic aminoglycosides may increase the risk of ototoxicity and nephrotoxicity, although systemic absorption from ophthalmic drops is usually minimal.

Other Ophthalmic Preparations

If using other ophthalmic medications, allow at least 5-10 minutes between applications to prevent washout.

Storage

Store at room temperature, below 30°C. Protect from light. Do not freeze. Keep out of reach of children.

Overdose

Overdose from topical ocular administration is unlikely. If accidentally ingested, seek medical advice immediately. Symptoms of systemic corticosteroid or aminoglycoside overdose are rare with ophthalmic preparations.

Pregnancy & Lactation

Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Caution should be exercised when administered to a nursing mother. Consult your doctor before use if you are pregnant or breastfeeding.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

5 mL bottle10 mL bottle

Shelf Life

24 months (unopened). Discard 28 days after opening.

Availability

Pharmacies

Approval Status

Approved

Patent Status

Generic

Clinical Trials

Clinical trials have demonstrated the efficacy and safety of Dexamethasone and Gentamicin in combination for the treatment of inflammatory ocular conditions with bacterial infection.

Lab Monitoring

Intraocular pressure (IOP) should be checked frequently if used for 10 days or longer.

Doctor Notes

Careful ophthalmological examination is required before and during treatment.
Avoid prolonged use, especially in patients with glaucoma or a history of elevated IOP.
Patients should be advised not to wear contact lenses during treatment of ocular infection/inflammation.

Patient Guidelines

Follow your doctor's instructions exactly.
Do not stop using this medicine suddenly without consulting your doctor.
Avoid contaminating the dropper tip with your eye, fingers, or any other surface.
Remove contact lenses before applying the drops and wait at least 15 minutes before reinserting them.

Missed Dose Advice

If a dose is missed, apply it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not apply a double dose to make up for a missed one.