Medicine Information

Dexoprex

Name: Dexoprex
Brand: Dexoprex
Rating: 4.5 (117 reviews)

Capsule30 mgProton Pump Inhibitor (PPI)ATC: A02BC05

Generic Name

Esomeprazole 30 mg

Manufacturer

Beximco Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
dexoprex 30 mg capsule	৳ 10.00	৳ 100.00

Description

Overview of the medicine

Dexoprex 30 mg Capsule contains Esomeprazole, a proton pump inhibitor used to reduce stomach acid production. It is prescribed for conditions like GERD, peptic ulcers, and Zollinger-Ellison syndrome.

Uses & Indications

Gastroesophageal Reflux Disease (GERD)

Erosive Esophagitis

Healing of Gastric Ulcers

H. pylori eradication (in combination therapy)

Zollinger-Ellison Syndrome

NSAID-associated ulcer prophylaxis

Dosage

Adults

Typically 20-40 mg once daily. For severe GERD, 40 mg once daily for 4-8 weeks. For Zollinger-Ellison syndrome, up to 120 mg three times daily.

Elderly

No dose adjustment required for elderly patients.

Renal_impairment

No dose adjustment required for patients with mild to moderate renal impairment. Caution with severe impairment.

How to Take

Take the capsule whole, at least one hour before a meal, preferably in the morning. Do not chew or crush.

Mechanism of Action

Esomeprazole, a proton pump inhibitor, specifically inhibits the H+/K+-ATPase enzyme system (proton pump) in the gastric parietal cells. This inhibition prevents the final step of acid production, leading to a profound and long-lasting reduction in gastric acid secretion.

Pharmacokinetics

Onset

Within 1 hour

Excretion

Mainly excreted in urine (approximately 80%) and feces (approximately 20%) as metabolites.

Half life

Approximately 1.5 hours

Absorption

Rapidly absorbed after oral administration; bioavailability is about 64% (increasing to 89% with repeated dosing).

Metabolism

Extensively metabolized in the liver by the cytochrome P450 (CYP) enzyme system, primarily by CYP2C19 and CYP3A4.

Side Effects

Contraindications

Hypersensitivity to Esomeprazole, substituted benzimidazoles, or any component of the formulation
Concomitant use with nelfinavir

Drug Interactions

Warfarin

Increased INR/prothrombin time; monitor closely.

Clopidogrel

Reduced antiplatelet effect; avoid concomitant use if possible.

Methotrexate

Possible increased methotrexate levels; monitor for toxicity.

Ketoconazole, Itraconazole

Reduced absorption due to increased gastric pH.

Storage

Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.

Overdose

Limited experience with overdose. Symptoms may include drowsiness, tachycardia, nausea, headache, and confusion. Treatment is symptomatic and supportive.

Pregnancy & Lactation

Pregnancy Category B. Use only if clearly needed. Excretion into breast milk is unknown, use with caution.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 capsules/strip30 capsules/box

Shelf Life

24 months

Availability

Pharmacies, hospitals, clinics

Approval Status

Approved by FDA/DGDA

Patent Status

Off-patent (Generic available)

WHO Essential Medicine

Yes

Clinical Trials

Numerous clinical trials have demonstrated the efficacy and safety of Esomeprazole in various acid-related disorders, showing superior healing rates for erosive esophagitis compared to older PPIs.

Lab Monitoring

Liver function tests (for long-term use or hepatic impairment)
Magnesium levels (for long-term use)
Chromogranin A (CgA) levels (may be elevated with PPI use)

Doctor Notes

Consider potential drug interactions, especially with Clopidogrel and Methotrexate.
Advise patients on lifestyle modifications.
Periodically reassess the need for continued PPI therapy.

Patient Guidelines

Take as directed by your doctor.
Do not stop taking the medication abruptly.
Inform your doctor about all other medications you are taking.
Report any unusual or severe side effects.

Missed Dose Advice

If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose.