Medicine Information

Dianide

Name: Dianide
Brand: Dianide
Rating: 4.5 (117 reviews)

Tablet500 mgAntidiabeticATC: A10BA02

Generic Name

Metformin Hydrochloride

Manufacturer

Generic Pharma Inc.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
dianide 500 mg tablet	৳ 10.07	৳ 30.22

Description

Overview of the medicine

Dianide 500 mg Tablet contains Metformin Hydrochloride, an oral antidiabetic drug used to manage type 2 diabetes mellitus. It helps to lower blood glucose levels by decreasing glucose production in the liver and improving insulin sensitivity.

Uses & Indications

Type 2 Diabetes Mellitus (as monotherapy or in combination with other antidiabetic agents)

Polycystic Ovary Syndrome (off-label use)

Dosage

Adults

Initial dose 500 mg once or twice daily with meals. Max dose 2000-2550 mg/day.

Elderly

Dose adjustment may be necessary due to potential decreased renal function. Renal function should be monitored regularly.

Renal_impairment

Contraindicated if eGFR < 30 mL/min/1.73 m². Dose reduction if eGFR 30-45 mL/min/1.73 m².

How to Take

Dianide 500 mg Tablet is taken orally, usually with meals, to reduce gastrointestinal side effects.

Mechanism of Action

Metformin decreases hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization.

Pharmacokinetics

Onset

Within days of starting therapy, full effect in 2 weeks.

Excretion

Excreted unchanged in the urine.

Half life

Approximately 6.2 hours.

Absorption

Bioavailability is 50-60%. Food decreases absorption. Peak plasma concentration is reached in 2-3 hours.

Metabolism

Not metabolized.

Side Effects

Contraindications

Severe renal impairment (eGFR < 30 mL/min/1.73 m²)
Acute or chronic metabolic acidosis, including diabetic ketoacidosis
Hypersensitivity to metformin

Drug Interactions

Iodinated Contrast Agents

Increased risk of lactic acidosis. Temporarily discontinue before or at the time of the procedure.

Carbonic Anhydrase Inhibitors (e.g., topiramate)

May increase the risk of lactic acidosis.

Cationic Drugs (e.g., amiloride, digoxin, morphine, ranitidine, triamterene)

May compete for renal tubular transport, increasing metformin concentration.

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

Overdose of Metformin can lead to lactic acidosis. Management includes hemodialysis to remove metformin, supportive treatment, and correction of acidosis.

Pregnancy & Lactation

Pregnancy: Generally, insulin is preferred for blood glucose control during pregnancy. Metformin may be considered in some cases under strict medical supervision. Lactation: Metformin is excreted into breast milk. Benefits of breastfeeding versus risk to infant should be considered.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

30 tablets (3x10's)100 tablets (10x10's)

Shelf Life

36 months from manufacturing date.

Availability

Pharmacies, Hospitals

Approval Status

Generally approved by major regulatory bodies (e.g., FDA, DGDA)

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Metformin has been extensively studied in clinical trials for type 2 diabetes, often as a first-line therapy. Ongoing research explores its potential in other conditions like cancer and aging.

Lab Monitoring

Renal function (eGFR) before initiation and at least annually
HbA1c (every 3-6 months)
Vitamin B12 levels (for long-term use, especially if symptoms of deficiency appear)

Doctor Notes

Emphasize patient education on lactic acidosis symptoms and when to seek emergency care.
Advise regular monitoring of renal function and vitamin B12 levels, especially in elderly patients or those on long-term therapy.

Patient Guidelines

Take Dianide 500 mg Tablet with meals to minimize gastrointestinal upset.
Do not crush or chew extended-release tablets.
Inform your doctor if you have kidney problems, are pregnant, or breastfeeding.
Report any symptoms of lactic acidosis (e.g., unusual muscle pain, difficulty breathing, unusual stomach discomfort, dizziness, lightheadedness, slow or irregular heartbeat).

Missed Dose Advice

If a dose is missed, take it as soon as remembered with food. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.

Driving Precautions

Generally does not cause hypoglycemia when used alone, thus unlikely to impair driving ability. However, if used in combination with other antidiabetic agents that can cause hypoglycemia, caution is advised.