Medicine Information

Diapizi

Name: Diapizi
Brand: Diapizi
Rating: 4.5 (117 reviews)

Tablet25 mgAntidepressant, AnxiolyticATC: N06AX17 (hypothetical)

Generic Name

Pizirapam Hydrochloride

Manufacturer

Fictional Pharma Inc.

Country

Bangladesh (Hypothetical)

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
diapizi 25 mg tablet	৳ 1.00	N/A

Description

Overview of the medicine

Diapizi 25 mg Tablet contains Pizirapam Hydrochloride, a hypothetical selective serotonin reuptake enhancer (SSRE) indicated for the treatment of major depressive disorder and generalized anxiety disorder. It helps in restoring the balance of certain natural substances (neurotransmitters) in the brain.

Uses & Indications

Major Depressive Disorder

Generalized Anxiety Disorder

Panic Disorder with or without agoraphobia

Dosage

Adults

Initial dose 25 mg once daily, preferably in the evening. May be increased to 50 mg daily after 1 week based on response and tolerability. Max dose 75 mg daily.

Elderly

Initial dose 12.5 mg once daily. Max 50 mg daily. Dose adjustments should be made carefully due to increased sensitivity and potential for adverse effects.

Renal_impairment

Mild to moderate impairment: No initial dose adjustment. Severe impairment: Initial dose 12.5 mg once daily. Use with caution.

How to Take

Diapizi Tablet should be swallowed whole with water, with or without food. Do not chew or crush the tablet.

Mechanism of Action

Pizirapam is hypothesized to selectively enhance the reuptake of serotonin from the synaptic cleft, potentially leading to improved neurotransmission in mood and anxiety-related pathways. Unlike SSRIs, it acts by enhancing rather than inhibiting reuptake, resulting in distinct pharmacological effects.

Pharmacokinetics

Onset

Initial therapeutic effects may be observed within 1-2 weeks, with full effects typically seen after 4-6 weeks of consistent use.

Excretion

Excreted mainly through the kidneys as inactive metabolites, with a small percentage excreted in feces.

Half life

Approximately 12-18 hours.

Absorption

Rapidly absorbed from the gastrointestinal tract, with peak plasma concentrations achieved within 1-2 hours.

Metabolism

Primarily metabolized in the liver via CYP450 enzymes (e.g., CYP2D6 and CYP3A4).

Side Effects

Contraindications

Hypersensitivity to Pizirapam or any excipients of the tablet.
Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of discontinuing MAOI therapy.

Drug Interactions

MAOIs

Concurrent use is contraindicated due to risk of serotonin syndrome.

Alcohol

May potentiate central nervous system depressant effects; avoid concomitant use.

Warfarin

May enhance anticoagulant effects; monitor INR closely.

SSRIs/SNRIs

Increased risk of serotonin syndrome, use with caution.

Storage

Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose may include severe dizziness, drowsiness, confusion, rapid heart rate, tremors, seizures, and possibly coma. Treatment is symptomatic and supportive, including maintaining an open airway, monitoring cardiac and vital signs, and gastric lavage if ingested recently. Activated charcoal may be considered.

Pregnancy & Lactation

Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Pizirapam is likely excreted in human milk; use with caution in breastfeeding mothers, weighing benefits against risks.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets (1x10)30 tablets (3x10)

Shelf Life

36 months from the date of manufacture.

Availability

Available in pharmacies (hypothetical)

Approval Status

Hypothetically approved by regulatory bodies

Patent Status

Under patent protection (hypothetical)

Clinical Trials

Hypothetical Phase III clinical trials demonstrated efficacy in reducing Hamilton Depression Rating Scale (HDRS) and Hamilton Anxiety Rating Scale (HARS) scores compared to placebo, with an acceptable safety profile.

Lab Monitoring

Liver function tests (baseline and periodically)
Renal function tests (baseline and periodically)
Electrolyte levels (periodically, especially with diuretics)

Doctor Notes

Educate patients on the delayed onset of action and the importance of continuous therapy.
Monitor for signs of serotonin syndrome, especially if co-administered with other serotonergic agents.
Counsel patients on potential sexual side effects and management strategies.

Patient Guidelines

Take exactly as prescribed by your doctor.
Do not stop taking Diapizi suddenly without consulting your doctor, as this may lead to withdrawal symptoms.
Avoid alcohol while on this medication.
Report any unusual mood changes or suicidal thoughts to your doctor immediately.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your usual dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

Diapizi may cause dizziness, drowsiness, or blurred vision. Patients should be advised not to drive or operate hazardous machinery until they know how the medication affects them.