Medicine Information

Diatrol

Name: Diatrol
Brand: Diatrol
Rating: 4.5 (117 reviews)

Tablet80 mgOral Hypoglycemic AgentsATC: A10BB09

Generic Name

Gliclazide

Manufacturer

Reputable Pharmaceutical Company

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
diatrol 80 mg tablet	৳ 8.00	৳ 80.00

Description

Overview of the medicine

Diatrol 80 mg Tablet contains Gliclazide, an oral hypoglycemic agent from the sulfonylurea class, used to control high blood sugar levels in adults with type 2 diabetes mellitus. It stimulates insulin release from the pancreatic beta cells.

Uses & Indications

Management of type 2 diabetes mellitus in adults, especially when dietary control and exercise alone are insufficient to achieve adequate glycemic control.

As an adjunct to diet and exercise to lower blood glucose in patients with non-insulin-dependent (type 2) diabetes.

Dosage

Adults

Initial dose: 40-80 mg once daily, preferably with breakfast. Gradually increase if needed, up to a maximum of 320 mg/day in divided doses. Standard maintenance dose: 80-160 mg/day.

Elderly

Initial dose 40 mg once daily, adjusted carefully based on glycemic response and renal function.

Renal_impairment

Mild to moderate renal impairment: Usually no dosage adjustment needed, but careful monitoring is advised. Severe renal impairment: Not recommended, or use with extreme caution at reduced doses.

How to Take

Oral administration. Take preferably with breakfast or the first main meal of the day. Swallow the tablet whole with water; do not crush or chew. Adhere to diet and exercise recommendations.

Mechanism of Action

Gliclazide works by stimulating the beta cells in the pancreas to release more insulin. It binds to the sulfonylurea receptor (SUR1) on the pancreatic beta-cell membrane, leading to the closure of ATP-sensitive potassium channels, membrane depolarization, calcium influx, and subsequent insulin secretion.

Pharmacokinetics

Onset

Typically within 1-2 hours.

Excretion

Mainly excreted in urine (less than 1% as unchanged drug) and faeces.

Half life

About 8-20 hours (for conventional tablets).

Absorption

Rapidly and completely absorbed from the gastrointestinal tract. Peak plasma concentrations are reached within 2-4 hours.

Metabolism

Extensively metabolized in the liver (primarily via CYP2C9) to inactive metabolites.

Side Effects

Contraindications

Hypersensitivity to gliclazide or other sulfonylureas or any excipients.
Type 1 diabetes mellitus.
Diabetic ketoacidosis.
Severe renal or hepatic insufficiency.
Concomitant use with miconazole (systemic formulation).
Pregnancy and breastfeeding.

Drug Interactions

Miconazole

Potentiates hypoglycemic effect, leading to severe hypoglycemia. Concomitant use is contraindicated.

Phenylbutazone, Alcohol, Sulfonamides, NSAIDs, Beta-blockers

May potentiate the hypoglycemic effect of gliclazide.

Corticosteroids, Diuretics, Barbiturates, Estrogens, Progestogens

May reduce the hypoglycemic effect of gliclazide.

Storage

Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

Symptoms include severe hypoglycemia (e.g., sweating, trembling, confusion, unconsciousness). Management involves immediate glucose administration (oral glucose for conscious patients, intravenous glucose or glucagon for unconscious patients) and monitoring for at least 24-48 hours due to prolonged hypoglycemic effects.

Pregnancy & Lactation

Contraindicated during pregnancy and breastfeeding. Insulin is the preferred treatment for diabetes in pregnant women. Consult a doctor for alternative management.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets per strip30 tablets per box (3 strips of 10)

Shelf Life

24 to 36 months from manufacturing date

Availability

Pharmacies nationwide

Approval Status

Approved

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Extensive clinical trials have established the efficacy and safety of gliclazide in managing type 2 diabetes, including studies on cardiovascular outcomes with modified-release formulations (e.g., ADVANCE trial).

Lab Monitoring

Blood glucose levels (fasting, postprandial, HbA1c)
Renal function tests (creatinine, GFR)
Liver function tests (ALT, AST, bilirubin) periodically
Blood counts periodically

Doctor Notes

Emphasize patient education on hypoglycemia recognition and management.
Regularly assess renal and hepatic function, especially in elderly patients.
Consider modified-release formulations for once-daily dosing and potentially better tolerability.
Counsel patients on adherence to diet and exercise as cornerstone of diabetes management.

Patient Guidelines

Take this medicine regularly as prescribed by your doctor.
Maintain a consistent diet and exercise regimen.
Monitor blood sugar levels regularly as advised.
Be aware of symptoms of hypoglycemia and how to manage them (e.g., carry sugar candy).
Inform your doctor about all other medications you are taking.

Missed Dose Advice

If a dose is missed, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and resume your regular dosing schedule. Do not double the dose to make up for a missed one.

Driving Precautions

Gliclazide can cause hypoglycemia, which may impair your ability to drive or operate machinery. If you experience symptoms of hypoglycemia, do not drive or use machines. Be particularly careful at the start of treatment or when changing dosage.