Medicine Information

Diazid MR

Name: Diazid MR
Brand: Diazid MR
Rating: 4.5 (117 reviews)

Tablet30 mgOral Hypoglycemic AgentsATC: A10BB09

Generic Name

Gliclazide Modified Release

Manufacturer

Incepta Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
diazid mr 30 mg tablet	৳ 7.00	৳ 70.00

Description

Overview of the medicine

Gliclazide is an oral antidiabetic drug used to manage type 2 diabetes mellitus in adults. It belongs to the sulfonylurea class and works by stimulating insulin release from pancreatic beta cells. The modified-release (MR) formulation allows for once-daily dosing and provides prolonged glycemic control.

Uses & Indications

Management of Type 2 Diabetes Mellitus in adults, when diet, exercise, and weight reduction alone are insufficient to control blood glucose levels.

As an adjunct to diet and exercise to improve glycemic control.

Dosage

Adults

The usual starting dose is 30 mg once daily, taken with breakfast. The dose can be adjusted in increments of 30 mg, up to a maximum of 120 mg once daily, based on blood glucose response.

Elderly

No specific dose adjustment is usually required, but careful monitoring of blood glucose is advised due to increased risk of hypoglycemia.

Renal_impairment

In mild to moderate renal impairment (creatinine clearance 30-60 mL/min), the standard dosing regimen may be used with careful monitoring. Avoid in severe renal impairment.

How to Take

Diazid MR tablet should be taken orally once daily with breakfast. The tablet must be swallowed whole with a glass of water, not chewed, crushed, or divided.

Mechanism of Action

Gliclazide acts by stimulating insulin secretion from pancreatic beta cells. It binds to the sulfonylurea receptor (SUR1) on the beta-cell membrane, leading to the closure of ATP-sensitive potassium channels. This depolarization opens voltage-dependent calcium channels, increasing intracellular calcium, which triggers insulin exocytosis.

Pharmacokinetics

Onset

Glycemic control typically begins within a few hours of the first dose, with full effects seen after a few days of consistent dosing.

Excretion

Metabolites are primarily excreted in the urine (about 60-70%) and feces (10-20%).

Half life

The apparent plasma half-life of gliclazide MR is approximately 12-20 hours, allowing for once-daily administration.

Absorption

Well absorbed from the gastrointestinal tract. The modified release formulation results in a gradual and sustained absorption. Peak plasma concentrations are typically reached within 6-12 hours after administration.

Metabolism

Extensively metabolized in the liver, primarily by the cytochrome P450 enzyme CYP2C9, into inactive metabolites. Less than 1% is excreted unchanged in the urine.

Side Effects

Contraindications

Hypersensitivity to gliclazide, other sulfonylureas, or any excipients.
Type 1 Diabetes Mellitus.
Diabetic ketoacidosis, diabetic precoma and coma.
Severe renal or hepatic insufficiency.
Concomitant use with miconazole (oral, systemic gel).
Pregnancy and lactation.

Drug Interactions

Anticoagulants (e.g., Warfarin)

Gliclazide may potentiate the effect of anticoagulants, requiring dose adjustment and monitoring.

Miconazole (systemic, oral gel)

Potentiates the hypoglycemic effect with possible onset of hypoglycemia, even coma.

Phenylbutazone, Alcohol, other antidiabetics

Increased risk of hypoglycemia.

Corticosteroids, Danazol, Chlorpromazine, Ritodrine, Salbutamol (IV), Diuretics

May decrease the hypoglycemic effect, leading to hyperglycemia.

Storage

Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach and sight of children.

Overdose

Overdose may lead to severe hypoglycemia. Symptoms include sweating, pallor, hunger, tremors, confusion, headache, and in severe cases, seizures or coma. Management involves immediate administration of oral glucose (for conscious patients) or intravenous glucose/glucagon (for unconscious patients).

Pregnancy & Lactation

Gliclazide is contraindicated during pregnancy. Insulin is the preferred treatment for diabetes in pregnant women. It is also contraindicated during lactation as sulfonylureas may be excreted in breast milk.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets (1 strip)30 tablets (3 strips)

Shelf Life

Typically 2-3 years from the date of manufacture when stored under recommended conditions.

Availability

Available in pharmacies nationwide

Approval Status

Approved by DGDA

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Gliclazide MR has undergone extensive clinical trials demonstrating its efficacy and safety in achieving and maintaining glycemic control in patients with Type 2 Diabetes Mellitus. Studies have shown its cardiovascular safety profile compared to some older sulfonylureas.

Lab Monitoring

Fasting Blood Glucose (FBG)
Postprandial Blood Glucose (PPBG)
Glycated Hemoglobin (HbA1c)
Renal function tests (e.g., serum creatinine, eGFR)
Liver function tests (e.g., ALT, AST)

Doctor Notes

Emphasize the importance of consistent dosing with breakfast to minimize hypoglycemia risk.
Educate patients on recognizing and treating symptoms of hypoglycemia.
Regularly monitor HbA1c, FBG, and renal/hepatic function.
Consider dose adjustment in elderly or renally impaired patients with caution.

Patient Guidelines

Take Diazid MR exactly as prescribed by your doctor, usually once daily with breakfast.
Do not skip meals or delay eating, as this increases the risk of hypoglycemia.
Monitor your blood glucose levels regularly as advised by your healthcare provider.
Be aware of the symptoms of hypoglycemia (e.g., sweating, shaking, dizziness) and know how to treat it (e.g., with glucose tablets or sugary drinks).
Inform your doctor or pharmacist about all other medications, herbal products, and supplements you are taking.

Missed Dose Advice

If a dose is missed, take it as soon as you remember. However, if it's almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

Hypoglycemia (low blood sugar) can impair your concentration and ability to react, making it dangerous to drive or operate machinery. Be aware of your blood sugar levels and potential symptoms of hypoglycemia before driving.

Lifestyle Advice

Maintain a healthy and balanced diet, consistent with diabetes management guidelines.
Engage in regular physical activity as recommended by your doctor.
Avoid excessive alcohol consumption, as it can increase the risk of hypoglycemia.
Quit smoking to improve overall health and diabetes control.