Medicine Information

doxiflo

Name: doxiflo
Brand: doxiflo
Rating: 4.5 (117 reviews)

Tablet400 mgBronchodilatorsATC: R03DA11

Generic Name

Doxofylline

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
doxiflo 400 mg tablet	৳ 10.00	৳ 100.00

Description

Overview of the medicine

Doxofylline is a bronchodilator used to treat bronchial asthma and chronic obstructive pulmonary disease (COPD). It helps to relax the muscles in the airways, making breathing easier.

Uses & Indications

Bronchial Asthma

Chronic Obstructive Pulmonary Disease (COPD)

Chronic Bronchitis

Dosage

Adults

400 mg orally, 2-3 times daily, adjusted according to clinical response and tolerability. Maximum dose usually 1200 mg/day.

Elderly

Similar to adults, but caution is advised due to potential for altered pharmacokinetics; lower doses may be considered.

Renal_impairment

Use with caution. Dose adjustment may be necessary in severe renal impairment.

How to Take

Doxofylline tablets should be taken orally, with or without food. Swallow the tablet whole with water; do not crush or chew.

Mechanism of Action

Doxofylline acts as a phosphodiesterase inhibitor, leading to an increase in intracellular cyclic AMP (cAMP) levels. This results in bronchodilation and also exhibits anti-inflammatory effects. Unlike theophylline, it has a better safety profile and fewer drug interactions.

Pharmacokinetics

Onset

Bronchodilatory effects typically begin within 30-60 minutes.

Excretion

Mainly excreted in the urine as metabolites.

Half life

Approximately 6-10 hours, varying among individuals.

Absorption

Rapidly absorbed from the gastrointestinal tract after oral administration.

Metabolism

Extensively metabolized in the liver (primarily via CYP450 system) to inactive metabolites.

Side Effects

Contraindications

Hypersensitivity to doxofylline or other xanthine derivatives
Acute myocardial infarction
Hypotension
Severe cardiac arrhythmias

Drug Interactions

Cimetidine

May increase plasma concentrations of doxofylline by inhibiting its metabolism.

Erythromycin

Can increase doxofylline levels, requiring dose adjustment.

Phenobarbital/Phenytoin

May decrease doxofylline efficacy by inducing its metabolism.

Storage

Store below 30°C in a cool, dry place. Protect from light and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose include severe nausea, vomiting, epigastric pain, headache, tachycardia, ventricular arrhythmias, and convulsions. Management is symptomatic and supportive, including gastric lavage and administration of activated charcoal. Close cardiac monitoring is essential.

Pregnancy & Lactation

Pregnancy Category C. Use with caution during pregnancy; weigh potential benefits against risks. Doxofylline is excreted in breast milk, so caution is advised for nursing mothers.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets per strip3 strips per box (30 tablets)

Shelf Life

Usually 2-3 years from the date of manufacture, specific details on packaging.

Availability

Pharmacies, hospitals

Approval Status

Approved

Patent Status

Generic available

Clinical Trials

Several clinical trials have demonstrated doxofylline's efficacy and safety in managing asthma and COPD, often showing a better tolerability profile compared to theophylline.

Lab Monitoring

Routine monitoring of doxofylline plasma levels is generally not required, unlike theophylline. However, clinical monitoring for efficacy and side effects is important.

Doctor Notes

Consider dose reduction in patients with hepatic impairment.
Monitor for gastrointestinal disturbances and central nervous system effects.
Advise patients to avoid abrupt discontinuation without medical consultation.

Patient Guidelines

Take the medicine exactly as prescribed by your doctor.
Do not exceed the recommended dose.
Inform your doctor about any other medications you are taking.
Report any unusual or severe side effects immediately.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.

Driving Precautions

Doxofylline may cause dizziness or blurred vision in some individuals. Patients should be cautious when driving or operating machinery until they know how the medicine affects them.