Medicine Information

Edone

Name: Edone
Brand: Edone
Rating: 4.5 (117 reviews)

Suspension5 mg/5 mlProkinetic, AntiemeticATC: A03FA03

Generic Name

Domperidone

Manufacturer

Aristopharma Ltd.

Country

Bangladesh

Loading images...

Price Details

Current market pricing information

Variant	Unit Price	Strip Price
edone 5 mg suspension	৳ 31.00	N/A

Description

Overview of the medicine

Edone 5 mg Suspension contains Domperidone, an antiemetic and prokinetic agent used to treat nausea, vomiting, dyspepsia, and gastroesophageal reflux disease (GERD). It works by blocking dopamine receptors in the chemoreceptor trigger zone (CTZ) and enhancing gastrointestinal motility.

Uses & Indications

Nausea and vomiting of various origins

Dyspeptic symptom complex (bloating, early satiety, epigastric pain)

Gastroesophageal reflux disease (GERD) symptoms

Functional dyspepsia

To enhance gastrointestinal motility in specific conditions

Dosage

Adults

Typically 10-20 mg three times daily before meals. For suspension, 10 ml (10 mg) three times daily is common, but may vary based on condition and prescriber.

Elderly

Similar to adult dose, but caution is advised due to potential for prolonged QTc interval. Initiate with the lowest effective dose.

Renal_impairment

Dosage frequency should be reduced to once or twice daily depending on the severity of impairment. For severe impairment (CrCl < 30 mL/min), frequency should be reduced to once or twice daily.

How to Take

Shake the bottle well before each use. Take the suspension orally, preferably 15-30 minutes before meals. Measure the dose accurately using the provided measuring cup or spoon.

Mechanism of Action

Domperidone acts as a peripheral dopamine D2 receptor antagonist. It blocks dopamine receptors in the chemoreceptor trigger zone (CTZ) located outside the blood-brain barrier, reducing nausea and vomiting. It also enhances gastrointestinal peristalsis by increasing esophageal and gastric motility and improving gastroduodenal coordination, which helps with symptoms of dyspepsia and reflux.

Pharmacokinetics

Onset

15-30 minutes for antiemetic effect.

Excretion

Excreted approximately 60% via feces and 30-35% via urine, primarily as metabolites.

Half life

Approximately 7-9 hours (can be prolonged in severe renal impairment).

Absorption

Rapidly absorbed after oral administration, peak plasma concentrations occur within 30-60 minutes.

Metabolism

Extensively metabolized in the liver by cytochrome P450 enzymes (primarily CYP3A4).

Side Effects

Contraindications

Known hypersensitivity to domperidone or any component of the formulation
Patients with moderate to severe hepatic impairment
Patients with known prolongation of cardiac QTc intervals, significant electrolyte disturbances, or underlying cardiac diseases (e.g., congestive heart failure)
Concomitant use with QT-prolonging drugs or potent CYP3A4 inhibitors
Patients with prolactinoma
Patients with gastrointestinal hemorrhage, mechanical obstruction, or perforation

Drug Interactions

Anticholinergics

May antagonize the prokinetic effect of domperidone.

Antacids/H2 blockers

May reduce oral bioavailability of domperidone. Take domperidone before meals and antacids after meals.

Potent CYP3A4 inhibitors (e.g., ketoconazole, erythromycin, ritonavir)

Increased plasma levels of domperidone, increased risk of QTc prolongation.

QT-prolonging drugs (e.g., amiodarone, cisapride, some antipsychotics)

Increased risk of cardiac arrhythmias.

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children. Do not freeze.

Overdose

Symptoms of overdose include drowsiness, disorientation, extrapyramidal reactions (especially in children), and possibly QTc prolongation and cardiac arrhythmias. Treatment is symptomatic and supportive, including gastric lavage and activated charcoal if appropriate.

Pregnancy & Lactation

Pregnancy: Use only if clearly needed and the potential benefits outweigh the potential risks. Limited data are available. Lactation: Domperidone is excreted in breast milk in small amounts. Use with caution during breastfeeding, especially for premature infants or those with underlying cardiac risks. Consult a doctor.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

30 ml suspension60 ml suspension100 ml suspension

Shelf Life

Typically 24 to 36 months from manufacturing date, check packaging for exact details.

Availability

Pharmacies, Hospitals

Approval Status

Approved by regulatory authorities in many countries (e.g., DGDA in Bangladesh)

Patent Status

Generic available

Clinical Trials

Numerous clinical trials have evaluated domperidone for its antiemetic and prokinetic effects across various patient populations, including children and adults. Recent trials have focused on its safety profile, particularly cardiac risks, leading to revised dosing recommendations.

Lab Monitoring

No routine specific lab monitoring is required. However, in patients with underlying cardiac risk factors or concomitant use of QT-prolonging drugs, ECG monitoring may be considered.

Doctor Notes

Emphasize careful patient selection, especially avoiding patients with cardiac risk factors or concomitant QT-prolonging medications.
Prescribe the lowest effective dose for the shortest possible duration, generally not exceeding one week.
Educate patients on symptoms of cardiac issues and hyperprolactinemia.

Patient Guidelines

Do not exceed the prescribed dose or duration of treatment.
Report any signs of unusual heart rate, dizziness, or fainting to your doctor immediately.
Avoid taking this medicine with alcohol.
Inform your doctor about all other medications you are taking, especially other heart medicines or antifungals.

Missed Dose Advice

If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.