Medicine Information

Elena

Name: Elena
Brand: Elena
Rating: 4.5 (117 reviews)

Capsule40 mgProton Pump Inhibitors (PPIs)ATC: A02BC05

Generic Name

Esomeprazole Magnesium

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
elena 40 mg capsule	৳ 9.00	৳ 90.00

Description

Overview of the medicine

Elena 40 mg capsule contains Esomeprazole, a proton pump inhibitor that reduces the amount of acid produced in the stomach. It is used to treat conditions like GERD, stomach ulcers, and to eradicate H. pylori.

Uses & Indications

Gastroesophageal Reflux Disease (GERD) including erosive esophagitis

Healing of gastric and duodenal ulcers

Eradication of Helicobacter pylori (H. pylori) in combination with appropriate antibiotics

Prevention of NSAID-associated gastric ulcers

Zollinger-Ellison Syndrome

Dosage

Adults

For Erosive Esophagitis: 40 mg once daily for 4 to 8 weeks. For Symptomatic GERD: 20 mg once daily for 4 weeks. For H. pylori eradication: 40 mg once daily in combination with antibiotics for 10 days. For NSAID-associated ulcers: 20 mg once daily for 4-8 weeks. For Zollinger-Ellison Syndrome: 40 mg twice daily, adjusted as needed.

Elderly

No specific dose adjustment is generally required, but caution should be exercised in patients with severe hepatic impairment.

Renal_impairment

No dose adjustment is required in patients with renal impairment.

How to Take

Take one capsule orally at least one hour before a meal. Swallow the capsule whole with water. Do not chew or crush the capsule.

Mechanism of Action

Esomeprazole works by irreversibly blocking the H+/K+-ATPase enzyme system (the 'proton pump') in the gastric parietal cells. This action effectively inhibits the final step in acid production, leading to a sustained reduction in gastric acid secretion.

Pharmacokinetics

Onset

Within 1 hour.

Excretion

Approximately 80% is excreted in the urine as metabolites, and the remainder in the feces.

Half life

Approximately 1-1.5 hours.

Absorption

Rapidly absorbed after oral administration. Bioavailability is approximately 64% after a single 40 mg dose, increasing to 89% after repeated once-daily administration.

Metabolism

Extensively metabolized in the liver by the cytochrome P450 (CYP) enzyme system, mainly by CYP2C19 and CYP3A4.

Side Effects

Contraindications

Known hypersensitivity to Esomeprazole, substituted benzimidazoles, or any excipients in the formulation.
Concomitant use with nelfinavir.

Drug Interactions

Digoxin

Increased systemic exposure to digoxin.

Warfarin

Increased INR and prothrombin time, monitor carefully.

Clopidogrel

Decreased antiplatelet effect of clopidogrel (avoid concomitant use).

Methotrexate

Increased and prolonged elevated serum levels of methotrexate and/or its metabolite.

Atazanavir, Nelfinavir

Reduced plasma levels of these antiretrovirals (contraindicated with nelfinavir, avoid with atazanavir).

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

In case of overdose, symptoms are generally mild and reversible. No specific antidote is known. Treatment should be symptomatic and supportive.

Pregnancy & Lactation

Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Esomeprazole is likely excreted in human milk; caution should be exercised when administered to a nursing woman.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 capsules20 capsules30 capsules

Shelf Life

36 months from manufacturing date.

Availability

Available in pharmacies nationwide

Approval Status

Approved by regulatory bodies (e.g., DGDA, FDA)

Patent Status

Generic available, original patent expired

WHO Essential Medicine

Yes

Clinical Trials

Esomeprazole has undergone extensive clinical trials demonstrating its efficacy and safety in various acid-related disorders. Studies have shown superior efficacy compared to some other PPIs for certain indications.

Lab Monitoring

Monitor serum magnesium levels in patients on long-term PPI therapy, especially with concomitant diuretics.
Consider liver function tests in patients with severe hepatic impairment.

Doctor Notes

Prescribe the lowest effective dose for the shortest duration necessary for the condition.
Consider testing for H. pylori before initiating long-term PPI therapy for dyspepsia.
Advise patients on potential long-term risks with prolonged PPI use and discuss management strategies.

Patient Guidelines

Take the capsule whole with water, at least one hour before a meal.
Do not chew, crush, or open the capsule.
Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
Report any unusual or severe side effects to your doctor immediately.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

Esomeprazole is generally considered safe for driving and operating machinery. However, if you experience side effects like dizziness or visual disturbances, avoid such activities.

Lifestyle Advice

For GERD, avoid spicy foods, fatty foods, caffeine, alcohol, and large meals close to bedtime.
Elevate the head of your bed to reduce nighttime reflux symptoms.