Medicine Information

Emo-20

Name: Emo-20
Brand: Emo-20
Rating: 4.5 (117 reviews)

Tablet20 mgAntidepressantATC: N06AB10

Generic Name

Escitalopram Oxalate

Manufacturer

MediCare Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
emo 20 20 mg tablet	৳ 4.50	৳ 45.00

Description

Overview of the medicine

Emo-20 contains Escitalopram, a selective serotonin reuptake inhibitor (SSRI) used to treat major depressive disorder and generalized anxiety disorder. It works by restoring the balance of a natural substance (serotonin) in the brain.

Uses & Indications

Major Depressive Disorder (MDD)

Generalized Anxiety Disorder (GAD)

Panic Disorder with or without agoraphobia

Social Anxiety Disorder (Social Phobia)

Obsessive-Compulsive Disorder (OCD)

Dosage

Adults

Initial dose 10 mg once daily, may be increased to 20 mg once daily after at least one week. Maximum dose 20 mg/day.

Elderly

Recommended initial dose 5 mg once daily. Maximum recommended dose 10 mg/day.

Renal_impairment

No dosage adjustment needed for mild to moderate impairment. Use with caution in severe renal impairment (creatinine clearance < 30 mL/min).

How to Take

Take Emo-20 orally once daily, with or without food. It is generally recommended to take it in the morning to avoid potential insomnia, but can be taken at any time of day.

Mechanism of Action

Escitalopram selectively inhibits the reuptake of serotonin (5-HT) by presynaptic neurons, leading to increased serotonin concentration in the synaptic cleft. This potentiation of serotonergic neurotransmission is believed to be responsible for its antidepressant and anxiolytic effects.

Pharmacokinetics

Onset

Initial antidepressant effects may be seen within 2-4 weeks, full effects may take 8-12 weeks.

Excretion

Mainly excreted in urine (approximately 10%) and feces (approximately 27%) as metabolites.

Half life

Approximately 27-32 hours, allowing for once-daily dosing.

Absorption

Well absorbed orally, independent of food. Peak plasma concentrations are reached in approximately 5 hours.

Metabolism

Primarily metabolized in the liver by CYP2C19 and CYP3A4 to inactive or weakly active metabolites.

Side Effects

Contraindications

Hypersensitivity to Escitalopram or any component of the formulation.
Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of discontinuing MAOI treatment.
Concomitant use with Pimozide.
Congenital long QT syndrome or known acquired long QT interval.

Drug Interactions

MAOIs

Concurrent use is contraindicated due to risk of serotonin syndrome.

Pimozide

Concurrent use is contraindicated due to risk of QT prolongation.

Warfarin

Increased risk of bleeding; monitor INR.

NSAIDs/Aspirin

Increased risk of bleeding.

Lithium/Tryptophan

May increase serotonergic effects.

Tricyclic Antidepressants (TCAs)

May increase plasma levels of TCAs.

Storage

Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose include dizziness, tremor, agitation, somnolence, nausea, vomiting, sinus tachycardia, and rarely, seizures or serotonin syndrome. Treatment is supportive and symptomatic; ensure adequate airway, oxygenation, and ventilation. Activated charcoal may be considered.

Pregnancy & Lactation

Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Escitalopram is excreted in human milk; use with caution in nursing mothers.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets per blister, 3 blisters per carton30 tablets per bottle

Shelf Life

36 months from the date of manufacture

Availability

Available in pharmacies nationwide

Approval Status

Approved by DGDA

Patent Status

Patent expired

WHO Essential Medicine

Yes

Clinical Trials

Extensive clinical trials have demonstrated the efficacy and safety of Escitalopram in the treatment of major depressive disorder and various anxiety disorders. Studies have shown significant improvements in symptom scores compared to placebo.

Lab Monitoring

No specific routine lab monitoring is generally required. However, consider baseline and periodic monitoring of electrolytes (especially sodium) in patients at risk for hyponatremia. Liver and renal function tests may be considered in patients with pre-existing impairment.

Doctor Notes

Advise patients that full therapeutic effects may take several weeks.
Monitor for worsening depression, suicidality, or unusual behavioral changes, especially at the start of treatment or dose changes.
Educate patients about potential withdrawal symptoms and the importance of gradual dose reduction.

Patient Guidelines

Do not stop taking Emo-20 abruptly, as this may lead to withdrawal symptoms. Always consult your doctor before stopping or changing your dose.
It may take several weeks for the full antidepressant effect to be felt.
Report any unusual mood changes, agitation, or suicidal thoughts to your doctor immediately.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.