Medicine Information

Enterogermina

Name: Enterogermina
Brand: Enterogermina
Rating: 4.5 (117 reviews)

Oral Suspension2 billion spores/5 mlProbioticATC: A07FA

Generic Name

Bacillus clausii

Manufacturer

Sanofi

Country

Italy (original manufacturer), various countries for local production

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
enterogermina 2 billion suspension	৳ 70.00	N/A

Description

Overview of the medicine

Enterogermina 2 Billion Suspension is an oral probiotic preparation containing spores of Bacillus clausii. It is used to restore the balance of intestinal flora, especially when it's altered due to various conditions like antibiotic treatment or gastrointestinal infections, and to aid in the absorption of nutrients.

Uses & Indications

Treatment and prevention of intestinal dysbiosis (imbalance of intestinal flora).

Restoration of intestinal flora during or after antibiotic treatment.

Acute and chronic gastrointestinal disorders in infants and children.

Adjuvant therapy for diarrhea of various origins.

Improvement of vitamin absorption.

Dosage

Adults

Adults: 1 vial (2 billion spores/5 ml) 2-3 times daily.

Elderly

Elderly: Similar to adult dosage, 1 vial 2-3 times daily.

Renal_impairment

No specific dosage adjustment required. For infants and children: 1 vial (2 billion spores/5 ml) 1-2 times daily, as advised by a physician.

How to Take

Shake the vial well before use. The contents of the vial should be taken undiluted or diluted in water, milk, tea, or orange juice. Administer at regular intervals throughout the day.

Mechanism of Action

Bacillus clausii spores survive the acidic gastric barrier and reach the intestine where they germinate and proliferate, contributing to the restoration of the gut microbial flora. They also produce various vitamins (especially B vitamins) and have immunomodulatory effects, promoting a healthy gut environment.

Pharmacokinetics

Onset

Effects typically begin within 1-2 days of regular administration, with full restoration taking longer.

Excretion

Eliminated via feces as part of normal gut turnover.

Half life

Not applicable as it is a live organism acting locally.

Absorption

Bacillus clausii spores are not absorbed systemically; they act locally in the gastrointestinal tract.

Metabolism

Not applicable; they germinate and proliferate, contributing to gut metabolism but not undergoing systemic metabolism.

Side Effects

Contraindications

Known hypersensitivity to Bacillus clausii or any component of the formulation.

Drug Interactions

Antibiotics

Probiotics, including Bacillus clausii, may be inactivated by concurrent antibiotic therapy. It is advisable to administer Enterogermina between antibiotic doses (e.g., 2-3 hours apart).

Storage

Store below 30°C. Do not freeze. Protect from light and moisture. Keep out of reach of children.

Overdose

No cases of overdose have been reported with Bacillus clausii. It is considered safe even at higher doses due to its natural, non-pathogenic nature. Symptomatic treatment if any unusual reaction occurs.

Pregnancy & Lactation

Generally considered safe during pregnancy and lactation, as Bacillus clausii is a natural inhabitant of the gut. However, consult a healthcare professional before use.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

5 ml x 5 vials5 ml x 10 vials

Shelf Life

Typically 24 months from manufacturing date when stored correctly.

Availability

Pharmacies, drugstores

Approval Status

Approved by health authorities worldwide for its indications.

Patent Status

Off-patent

Clinical Trials

Numerous clinical trials have demonstrated the efficacy of Bacillus clausii in various gastrointestinal conditions, including acute diarrhea, antibiotic-associated diarrhea, and restoration of gut flora.

Lab Monitoring

No specific lab monitoring is required for Bacillus clausii administration.

Doctor Notes

Advise patients to complete the full course as prescribed, even if symptoms improve.
Emphasize proper storage to maintain viability of spores.
Can be safely co-administered with most medications, except antibiotics which should be spaced out.

Patient Guidelines

Shake the vial thoroughly before opening.
Do not exceed the recommended daily dose.
Consult a doctor if symptoms persist or worsen.
Complete the full course of treatment as advised by the doctor, especially during antibiotic therapy.

Missed Dose Advice

If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.