Medicine Information

Eram

Name: Eram
Brand: Eram
Rating: 4.5 (117 reviews)

Tablet5 mgAntidepressantsATC: N06AB10

Generic Name

Escitalopram

Manufacturer

Acme Laboratories Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
eram 05 mg tablet	৳ 7.00	৳ 70.00

Description

Overview of the medicine

Escitalopram is an antidepressant used to treat major depressive disorder and generalized anxiety disorder. It works by increasing serotonin levels in the brain.

Uses & Indications

Major Depressive Disorder (MDD)

Generalized Anxiety Disorder (GAD)

Obsessive-Compulsive Disorder (OCD)

Panic Disorder with or without agoraphobia

Social Anxiety Disorder (SAD)

Dosage

Adults

Initial 5 mg once daily, usually for a week before increasing to 10 mg. Maximum 20 mg daily.

Elderly

Initial 5 mg once daily, maximum 10 mg daily.

Renal_impairment

No dosage adjustment usually required for mild to moderate impairment. Use with caution in severe impairment.

How to Take

Orally, once daily, with or without food. Take at the same time each day.

Mechanism of Action

Selectively inhibits the reuptake of serotonin (5-HT) in the brain, increasing serotonin concentration in the synaptic cleft.

Pharmacokinetics

Onset

Clinical effects may take 2-4 weeks to become apparent.

Excretion

Primarily via urine, with some fecal excretion.

Half life

Approximately 27-32 hours.

Absorption

Well absorbed orally, unaffected by food. Peak plasma concentration reached in about 4 hours.

Metabolism

Primarily hepatic, via CYP2C19, CYP3A4, and CYP2D6 to inactive metabolites.

Side Effects

Contraindications

Hypersensitivity to escitalopram or citalopram.
Concomitant use with MAOIs (Monoamine Oxidase Inhibitors) or within 14 days of discontinuing an MAOI.
Concomitant use with pimozide.

Drug Interactions

MAOIs

Increased risk of serotonin syndrome.

Alcohol

Avoid concomitant use.

Pimozide

Increased QT prolongation.

Warfarin, NSAIDs

Increased risk of bleeding.

Other SSRIs/SNRIs

Increased risk of serotonin syndrome.

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

Symptoms: Dizziness, tremor, nausea, vomiting, somnolence, tachycardia, hypotension, rarely QT prolongation, arrhythmias, convulsions, serotonin syndrome. Management: Supportive and symptomatic treatment. Maintain airway, monitor cardiac and vital signs. Activated charcoal may be considered. No specific antidote.

Pregnancy & Lactation

Pregnancy: Category C. Use only if potential benefit outweighs risk. Neonatal withdrawal symptoms have been reported. Lactation: Excreted in breast milk. Use with caution, consult doctor.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets in a blister pack30 tablets in a blister pack

Shelf Life

Typically 2-3 years from manufacturing date.

Availability

Pharmacies, Hospitals

Approval Status

Approved by major regulatory bodies (e.g., FDA, DGDA)

Patent Status

Generic available

WHO Essential Medicine

Yes

Clinical Trials

Extensive clinical trials support its efficacy and safety for approved indications.

Lab Monitoring

Liver function tests (baseline and if clinically indicated)
Electrolytes (especially sodium, if hyponatremia suspected)
ECG (if cardiac risk factors or concomitant medications prolonging QT interval)

Doctor Notes

Counsel patients on delayed onset of action and importance of adherence.
Monitor for worsening depression and suicidality, especially at initiation or dose changes.
Assess for serotonin syndrome symptoms when co-administered with other serotonergic agents.