Medicine Information

Erazole

Name: Erazole
Brand: Erazole
Rating: 4.5 (117 reviews)

Capsule40 mgProton Pump Inhibitor (PPI)ATC: A02BC05

Generic Name

Esomeprazole

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
erazole 40 mg capsule	৳ 10.00	৳ 40.00

Description

Overview of the medicine

Erazole 40 mg Capsule contains Esomeprazole, a proton pump inhibitor (PPI) that reduces the amount of acid produced in your stomach. It is used to treat acid-related diseases of the stomach and gut.

Uses & Indications

Gastroesophageal Reflux Disease (GERD) including healing of erosive esophagitis and maintenance of healing.

Symptomatic GERD.

Risk reduction of NSAID-associated gastric ulcers.

Helicobacter pylori eradication (in combination with appropriate antibiotics).

Zollinger-Ellison Syndrome and other pathological hypersecretory conditions.

Dosage

Adults

For erosive esophagitis: 20 mg or 40 mg once daily for 4 to 8 weeks. For maintenance of healing: 20 mg once daily. For symptomatic GERD: 20 mg once daily for 4 weeks. For H. pylori eradication: 20 mg twice daily for 10 days (in combination with antibiotics). For Zollinger-Ellison Syndrome: Initial dose 40 mg twice daily, adjusted as needed.

Elderly

No dosage adjustment is generally needed, but monitor patients with severe hepatic impairment.

Renal_impairment

No dosage adjustment is necessary for patients with impaired renal function.

How to Take

Erazole capsules should be swallowed whole with water. Do not chew or crush the capsules. It is recommended to take the capsule at least one hour before a meal.

Mechanism of Action

Esomeprazole is a specific inhibitor of the H+/K+-ATPase (proton pump) in the gastric parietal cell. It inhibits both basal and stimulated acid secretion, leading to a profound and prolonged reduction in gastric acid secretion.

Pharmacokinetics

Onset

Onset of acid suppression occurs within one hour of oral administration.

Excretion

Approximately 80% of the dose is excreted as metabolites in the urine, and the remainder in the feces.

Half life

Plasma elimination half-life is approximately 1-1.5 hours.

Absorption

Rapidly absorbed after oral administration. Bioavailability is approximately 64% after a single 40 mg dose and increases to 89% with repeated once-daily administration.

Metabolism

Extensively metabolized in the liver by the cytochrome P450 (CYP) enzyme system, primarily by CYP2C19 and CYP3A4.

Side Effects

Contraindications

Hypersensitivity to esomeprazole, substituted benzimidazoles, or any component of the formulation.
Concomitant use with nelfinavir (an antiretroviral).

Drug Interactions

Warfarin

Increased INR and prothrombin time, potentially leading to abnormal bleeding.

Clopidogrel

Reduced antiplatelet effect of clopidogrel due to CYP2C19 inhibition.

Methotrexate

Increased and prolonged elevation of methotrexate and/or its metabolite serum levels.

Nelfinavir/Atazanavir

Decreased plasma concentrations of these antiretrovirals, reducing their efficacy.

Diazepam, Citalopram, Imipramine, Phenytoin

Increased plasma levels of these drugs due to inhibition of CYP2C19.

Storage

Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.

Overdose

There is limited experience with esomeprazole overdose. Symptoms are generally mild and reversible. Management should be symptomatic and supportive.

Pregnancy & Lactation

Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Esomeprazole is excreted in breast milk; caution should be exercised when administered to a nursing woman.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 capsules per strip20 capsules per box (2 strips x 10 capsules)

Shelf Life

24 to 36 months from the date of manufacture, when stored under recommended conditions.

Availability

Pharmacies, hospitals

Approval Status

Approved by major regulatory bodies (e.g., FDA, DGDA)

Patent Status

Generic available

WHO Essential Medicine

Yes

Clinical Trials

Esomeprazole has been extensively studied in numerous clinical trials demonstrating its efficacy and safety in the treatment of GERD, peptic ulcers, and H. pylori eradication. These trials have shown superior or comparable acid suppression to other PPIs.

Lab Monitoring

Periodic monitoring of serum magnesium levels is recommended in patients expected to be on prolonged treatment or who take PPIs with other drugs such as digoxin or diuretics.

Doctor Notes

Before initiating long-term PPI therapy, always rule out malignancy, especially in patients with alarm symptoms.
Consider the lowest effective dose for the shortest duration necessary for the condition being treated.
Educate patients about potential long-term risks, including bone fracture, C. difficile infection, and nutrient deficiencies (e.g., magnesium, B12).

Patient Guidelines

Take Erazole 40 mg capsule exactly as prescribed by your doctor.
Swallow the capsule whole; do not chew, crush, or open it.
Take the medicine at least one hour before a meal for best results.
Inform your doctor about any other medications you are taking, especially clopidogrel or warfarin.
Report any severe or persistent side effects to your doctor immediately.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

Esomeprazole may cause dizziness, drowsiness, or blurred vision in some individuals. If you experience these effects, avoid driving or operating machinery.

Lifestyle Advice

Avoid trigger foods that worsen your symptoms, such as fatty, spicy, acidic foods, chocolate, and caffeine.
Elevate the head of your bed to help reduce nighttime acid reflux symptoms.
Avoid smoking and excessive alcohol consumption, as these can exacerbate acid reflux.
Maintain a healthy weight, as obesity can contribute to GERD.