Medicine Information

Erofen

Name: Erofen
Brand: Erofen
Rating: 4.5 (117 reviews)

Tablet400 mgNon-steroidal Anti-inflammatory Drug (NSAID)ATC: M01AE01

Generic Name

Ibuprofen

Manufacturer

Incepta Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
erofen 400 mg tablet	৳ 1.35	N/A

Description

Overview of the medicine

Erofen 400 mg Tablet contains Ibuprofen, a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, reduce inflammation, and lower fever. It is commonly used for conditions like headache, dental pain, menstrual pain, muscle aches, and arthritis.

Uses & Indications

Relief of mild to moderate pain (e.g., headache, dental pain, back pain)

Reduction of fever

Management of menstrual pain (dysmenorrhea)

Treatment of inflammatory conditions like osteoarthritis, rheumatoid arthritis, juvenile idiopathic arthritis

Dosage

Adults

For mild to moderate pain and fever: 200 mg to 400 mg every 4 to 6 hours as needed. Maximum dose: 1200 mg per day for OTC use, up to 2400 mg per day under medical supervision. For inflammatory conditions: 400 mg to 600 mg three to four times a day.

Elderly

Start with lower doses and monitor for adverse effects, especially renal and gastrointestinal function. Adjust dose based on response and tolerability.

Renal_impairment

Use with caution. Dosage reduction may be necessary in patients with severe renal impairment. Regular monitoring of renal function is recommended.

How to Take

Take Erofen 400 mg Tablet orally, preferably with food or milk to minimize gastrointestinal upset. Swallow the tablet whole with a glass of water. Do not chew or crush it.

Mechanism of Action

Ibuprofen works by inhibiting cyclooxygenase (COX-1 and COX-2) enzymes, which are responsible for the synthesis of prostaglandins. Prostaglandins mediate pain, inflammation, and fever, so by reducing their production, Ibuprofen provides its therapeutic effects.

Pharmacokinetics

Onset

Analgesic effects typically begin within 30-60 minutes.

Excretion

The inactive metabolites and a small amount of unchanged drug are primarily excreted by the kidneys.

Half life

Approximately 1.8 to 2.5 hours.

Absorption

Rapidly absorbed from the gastrointestinal tract, with peak plasma concentrations occurring 1-2 hours after oral administration.

Metabolism

Extensively metabolized in the liver, primarily by oxidation via CYP2C9 and CYP2C8, to inactive metabolites.

Side Effects

Contraindications

Hypersensitivity to Ibuprofen or any component of the formulation
History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
Active gastrointestinal bleeding or peptic ulcer disease
Severe heart failure, renal impairment, or hepatic impairment
Third trimester of pregnancy
Coronary Artery Bypass Graft (CABG) surgery

Drug Interactions

SSRIs

Increased risk of gastrointestinal bleeding.

Lithium

Increased plasma lithium levels, leading to toxicity.

Methotrexate

Increased methotrexate toxicity.

Corticosteroids

Increased risk of gastrointestinal ulceration or bleeding.

Other NSAIDs or Aspirin

Increased risk of gastrointestinal side effects and bleeding.

Cyclosporine, Tacrolimus

Increased risk of nephrotoxicity.

Anticoagulants (e.g., Warfarin)

Increased risk of bleeding.

Diuretics (e.g., Furosemide, Thiazides)

Reduced diuretic and antihypertensive effects, increased risk of renal impairment.

ACE inhibitors and Angiotensin II Receptor Blockers (ARBs)

Reduced antihypertensive effect and increased risk of renal impairment.

Storage

Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose may include nausea, vomiting, abdominal pain, drowsiness, dizziness, headache, tinnitus, and nystagmus. Severe overdose can lead to renal failure, hypotension, metabolic acidosis, coma, and seizures. Management: There is no specific antidote. Treatment is supportive and symptomatic. Gastric lavage or activated charcoal may be considered if ingestion was recent (within 1 hour). Ensure adequate hydration and monitor vital signs, renal function, and electrolyte levels.

Pregnancy & Lactation

Pregnancy: Avoid Ibuprofen during the third trimester of pregnancy due to potential for premature closure of the fetal ductus arteriosus and potential for renal dysfunction in the fetus. In the first and second trimesters, use only if clearly needed and the potential benefit outweighs the potential risk to the fetus. Lactation: Ibuprofen is excreted in breast milk in very small amounts. It is generally considered compatible with breastfeeding when used at usual therapeutic doses for short durations.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets per strip30 tablets per box

Shelf Life

Typically 3 years from the date of manufacture.

Availability

Available in pharmacies and hospitals

Approval Status

Approved

Patent Status

Generic available

WHO Essential Medicine

Yes

Clinical Trials

Ibuprofen has undergone numerous clinical trials demonstrating its efficacy and safety for various pain, inflammation, and fever indications. Ongoing research continues to explore its applications and long-term effects.

Lab Monitoring

Complete Blood Count (CBC) (especially with long-term use)
Renal function tests (e.g., serum creatinine, BUN) (especially in patients with risk factors for renal impairment)
Liver function tests (e.g., ALT, AST) (especially with long-term use)

Doctor Notes

Assess patient's cardiovascular and gastrointestinal risk factors before initiating Ibuprofen.
Use the lowest effective dose for the shortest possible duration to minimize risks.
Monitor renal function, liver function, and blood pressure regularly in patients on long-term therapy.
Educate patients about the signs and symptoms of gastrointestinal bleeding and cardiovascular events.

Patient Guidelines

Always take this medicine with food or milk to reduce stomach upset.
Do not exceed the recommended dose or duration of treatment without consulting your doctor.
Avoid consuming alcohol while taking this medication as it may increase the risk of stomach bleeding.
Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
Report any severe stomach pain, black stools, or unusual bleeding/bruising to your doctor immediately.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.

Driving Precautions

Ibuprofen may cause dizziness, drowsiness, or visual disturbances in some individuals. If you experience these effects, avoid driving or operating machinery until you know how the medicine affects you.