Medicine Information

Esomep

Name: Esomep
Brand: Esomep
Rating: 4.5 (117 reviews)

Tablet40 mgProton Pump Inhibitor (PPI)ATC: A02BC05

Generic Name

Esomeprazole 40 mg Tablet

Manufacturer

Beximco Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
esomep 40 mg tablet	৳ 8.02 ((3 x 10: ৳ 240.60))	৳ 80.20

Description

Overview of the medicine

Esomeprazole is a proton pump inhibitor (PPI) that reduces the amount of acid produced in the stomach. It is used to treat conditions such as gastroesophageal reflux disease (GERD), erosive esophagitis, and ulcers.

Uses & Indications

Treatment of Gastroesophageal Reflux Disease (GERD)

Healing of erosive esophagitis

Maintenance of healing of erosive esophagitis

Symptomatic GERD

Risk reduction of NSAID-associated gastric ulcers

H. pylori eradication (in combination with antibiotics)

Zollinger-Ellison Syndrome

Dosage

Adults

For erosive esophagitis: 20 mg or 40 mg once daily for 4 to 8 weeks. For GERD symptoms: 20 mg once daily for 4 weeks. For H. pylori eradication: 40 mg once daily with amoxicillin and clarithromycin for 10 days.

Elderly

No specific dosage adjustment required; however, caution should be exercised in patients with severe hepatic impairment.

Renal_impairment

No dosage adjustment needed for renal impairment.

How to Take

Take orally, at least one hour before a meal. Swallow the tablet whole; do not chew or crush. For patients who have difficulty swallowing, the tablet can be dispersed in a glass of water.

Mechanism of Action

Esomeprazole is an irreversible proton pump inhibitor. It binds to and inhibits the H+/K+-ATPase enzyme system (the proton pump) in the gastric parietal cells, thereby blocking the final step in gastric acid secretion.

Pharmacokinetics

Onset

Within 1 hour

Excretion

Mainly excreted via urine (approximately 80%) and feces (approximately 20%).

Half life

Approximately 1-1.5 hours

Absorption

Rapidly absorbed after oral administration, bioavailability is approximately 64% at 40 mg dose, increasing with repeated dosing.

Metabolism

Extensively metabolized in the liver via CYP2C19 and CYP3A4 enzymes.

Side Effects

Contraindications

Hypersensitivity to esomeprazole, substituted benzimidazoles, or any component of the formulation.
Concomitant use with nelfinavir (an HIV protease inhibitor).

Drug Interactions

Warfarin

Increased INR/prothrombin time; monitor closely.

Clopidogrel

Reduced antiplatelet effect of clopidogrel due to inhibition of CYP2C19.

Methotrexate

Increased plasma levels of methotrexate, particularly at high doses.

Atazanavir, Nelfinavir

Reduced plasma levels of antiretrovirals; avoid co-administration with nelfinavir.

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

Experience with esomeprazole overdose is limited. Symptoms may include gastrointestinal disturbances and weakness. Treatment is symptomatic and supportive.

Pregnancy & Lactation

Pregnancy Category B. Studies in animals have not shown a risk, but human studies are insufficient. Use only if clearly needed. Excreted in human milk, use with caution during lactation.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets20 tablets30 tablets

Shelf Life

Typically 24 to 36 months from manufacturing date

Availability

Pharmacies, hospitals, clinics

Approval Status

Approved worldwide by regulatory bodies (e.g., FDA, EMA, DGDA)

Patent Status

Generic versions widely available

WHO Essential Medicine

Yes

Clinical Trials

Numerous clinical trials have established esomeprazole's efficacy and safety for its approved indications.

Lab Monitoring

Serum magnesium levels (especially with long-term use, or concomitant use with diuretics)
Vitamin B12 levels (with prolonged use, >3 years)

Doctor Notes

Consider tapering PPIs for patients on long-term therapy to avoid rebound acid hypersecretion.
Assess for potential drug interactions, especially with clopidogrel and methotrexate.
Monitor magnesium and vitamin B12 levels in patients on prolonged PPI therapy.

Patient Guidelines

Take exactly as prescribed by your doctor.
Do not stop taking the medicine without consulting your doctor, even if symptoms improve.
Report any unusual or severe side effects to your doctor immediately.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take two doses at once.

Driving Precautions

Esomeprazole is unlikely to affect the ability to drive or operate machinery. However, if you experience side effects like dizziness or blurred vision, avoid these activities.