Medicine Information

Esoz MUPS

Name: Esoz MUPS
Brand: Esoz MUPS
Rating: 4.5 (117 reviews)

Tablet (Multiple Unit Pellet System)20 mgProton Pump Inhibitors (PPIs)ATC: A02BC05

Generic Name

Esomeprazole (as magnesium trihydrate) 20 mg MUPS tablet

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
esoz mups 20 mg tablet	৳ 10.00	৳ 100.00

Description

Overview of the medicine

Esoz MUPS 20 mg tablet contains esomeprazole, a proton pump inhibitor, used to reduce stomach acid production. It is formulated as MUPS for improved absorption.

Uses & Indications

Gastroesophageal Reflux Disease (GERD)

Erosive Esophagitis

Zollinger-Ellison Syndrome

Peptic Ulcer Disease (PUD) including H. pylori eradication (in combination with antibiotics)

NSAID-associated gastric ulcers

Dosage

Adults

GERD: 20-40 mg once daily for 4-8 weeks. Erosive Esophagitis: 20-40 mg once daily for 4-8 weeks. Zollinger-Ellison: Initial 40 mg twice daily, adjust as needed.

Elderly

No dosage adjustment generally required, but caution in severe hepatic impairment.

Renal_impairment

No dosage adjustment needed for renal impairment.

How to Take

Take orally, preferably at least one hour before a meal. Swallow whole, do not crush or chew. May be dispersed in water for patients who have difficulty swallowing.

Mechanism of Action

Esomeprazole irreversibly binds to the H+/K+-ATPase enzyme (proton pump) in the gastric parietal cells, inhibiting the final step of acid secretion.

Pharmacokinetics

Onset

Within 1 hour

Excretion

Mainly excreted in urine (80%) and feces (20%) as metabolites.

Half life

Approximately 1-1.5 hours

Absorption

Rapidly absorbed after oral administration, bioavailability is approximately 64% with a single 20 mg dose, increasing to 89% with repeated once-daily administration.

Metabolism

Extensively metabolized in the liver by the cytochrome P450 system, primarily CYP2C19 and CYP3A4.

Side Effects

Contraindications

Hypersensitivity to esomeprazole or any proton pump inhibitor.
Concomitant use with nelfinavir.

Drug Interactions

Warfarin

Increased INR and prothrombin time.

Clopidogrel

Reduced antiplatelet effect.

Nelfinavir, Atazanavir

Reduced plasma levels of antiretrovirals.

Diazepam, Citalopram, Phenytoin

Increased plasma levels of these drugs.

Storage

Store below 30°C, in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

Symptoms may include drowsiness, tachycardia, nausea, abdominal pain. Treatment is symptomatic and supportive.

Pregnancy & Lactation

Pregnancy Category B. Use only if clearly needed. Esomeprazole is excreted in human breast milk; caution advised.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets per strip30 tablets per box

Shelf Life

Typically 24-36 months from manufacturing date

Availability

Pharmacies, Hospitals

Approval Status

Approved by DGDA/FDA

Patent Status

Generic available

WHO Essential Medicine

Yes

Clinical Trials

Numerous clinical trials have established the efficacy and safety of esomeprazole in various acid-related disorders. Studies have shown superior efficacy compared to some other PPIs in healing and preventing recurrence of erosive esophagitis.

Lab Monitoring

Magnesium levels (with long-term use)
Liver function tests
Creatinine

Doctor Notes

Consider dose reduction or discontinuation if symptoms resolve.
Monitor for potential drug interactions, especially with warfarin, clopidogrel, and antiretrovirals.
Evaluate need for continued PPI therapy periodically, especially for long-term users.
Advise patients on lifestyle modifications to manage acid reflux.

Patient Guidelines

Take as directed by your doctor.
Do not stop taking the medicine suddenly without consulting your doctor.
Inform your doctor about all other medications you are taking.
Report any severe or persistent side effects to your doctor.

Missed Dose Advice

Take the missed dose as soon as you remember. If it's almost time for the next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.