Medicine Information

Esypan

Name: Esypan
Brand: Esypan
Rating: 4.5 (117 reviews)

Tablet5 mgProton Pump Inhibitors (PPIs)ATC: A02BC05

Generic Name

Esomeprazole 5 mg Tablet

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
esypan 05 mg tablet	৳ 2.01	৳ 20.10

Description

Overview of the medicine

Esypan 5 mg Tablet contains Esomeprazole, a proton pump inhibitor (PPI) that reduces the amount of acid produced in the stomach. It is used to treat acid-related conditions such as gastroesophageal reflux disease (GERD), erosive esophagitis, and gastric ulcers.

Uses & Indications

Treatment of Gastroesophageal Reflux Disease (GERD)

Healing of erosive esophagitis

Long-term management of patients with healed esophagitis to prevent relapse

Symptomatic treatment of GERD

Healing and maintenance of NSAID-associated gastric ulcers

Zollinger-Ellison Syndrome

Dosage

Adults

The 5 mg strength is generally used for specific conditions or as maintenance, often in pediatric patients or for very mild symptoms. Typical adult doses for GERD or ulcers are 20 mg or 40 mg once daily. For specific uses of 5mg, follow physician's guidance.

Elderly

No specific dose adjustment is generally required for elderly patients based on age alone, but caution is advised in very frail or debilitated patients.

Renal_impairment

No dose adjustment is necessary for patients with impaired renal function.

How to Take

Take Esypan 5 mg Tablet orally, preferably in the morning at least one hour before a meal. Swallow the tablet whole with water. Do not crush, chew, or break the tablet as this may affect its enteric coating.

Mechanism of Action

Esomeprazole irreversibly blocks the H+/K+-ATPase enzyme system (the proton pump) in the gastric parietal cells. By inhibiting this enzyme, it prevents the final step in gastric acid secretion, leading to a significant and prolonged reduction in stomach acid production.

Pharmacokinetics

Onset

Acid suppression begins within one hour of oral administration.

Excretion

Approximately 80% of metabolites are excreted in the urine and the remaining 20% in the feces.

Half life

Approximately 1.5 hours in healthy subjects, but it has a longer duration of action due to irreversible binding.

Absorption

Rapidly absorbed after oral administration, with peak plasma concentrations typically achieved within 1 to 2 hours. Bioavailability increases with repeated dosing.

Metabolism

Extensively metabolized in the liver by the cytochrome P450 enzyme system, primarily by CYP2C19 and to a lesser extent by CYP3A4.

Side Effects

Contraindications

Known hypersensitivity to esomeprazole, substituted benzimidazoles, or any component of the formulation.
Concomitant use with nelfinavir (an HIV protease inhibitor).

Drug Interactions

Diazepam

May decrease the clearance of diazepam due to inhibition of CYP2C19.

Warfarin

Increased INR and prothrombin time have been reported, requiring monitoring.

Clopidogrel

Esomeprazole may reduce the antiplatelet effect of clopidogrel by inhibiting its conversion to active metabolite, especially at higher doses (e.g., 40 mg).

Methotrexate

May increase serum methotrexate levels, particularly at high doses of methotrexate, potentially leading to toxicity.

Ketoconazole, Itraconazole

Absorption of these drugs may be decreased due to esomeprazole-induced reduction in intragastric pH.

Storage

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.

Overdose

Limited experience with overdose. Symptoms may include gastrointestinal disturbances (e.g., nausea, vomiting, diarrhea) and CNS effects (e.g., headache, lethargy). Management is symptomatic and supportive. Hemodialysis is not effective for removing esomeprazole.

Pregnancy & Lactation

Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Esomeprazole and its metabolites are excreted in breast milk; caution is advised when administered to a nursing woman.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets per strip3 strips (30 tablets) per box

Shelf Life

36 months from the date of manufacture.

Availability

Pharmacies nationwide

Approval Status

Approved by DGDA

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Esomeprazole has been extensively studied in numerous clinical trials demonstrating its efficacy and safety for various acid-related disorders across different patient populations, including pediatric patients for appropriate indications.

Lab Monitoring

Routine laboratory monitoring is not generally required. However, for long-term use (over 3 months), magnesium levels should be monitored, as hypomagnesemia can occur.

Doctor Notes

Prescribe the lowest effective dose for the shortest duration necessary to achieve treatment goals.
Periodically reassess the need for continued PPI therapy, especially in patients on long-term treatment.
Be aware of potential drug interactions, particularly with clopidogrel and other drugs whose absorption is pH-dependent.

Patient Guidelines

Take the medicine exactly as prescribed by your doctor.
Do not crush, chew, or break the tablet; swallow it whole.
If symptoms do not improve or worsen, consult your doctor.
Inform your doctor about all other medications you are taking.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

Esypan 5 mg Tablet may cause dizziness or visual disturbances in some individuals. If you experience these effects, avoid driving or operating machinery until you know how the medicine affects you.

Lifestyle Advice

Avoid foods and beverages that may worsen acid reflux (e.g., spicy foods, fatty foods, caffeine, alcohol).
Eat smaller, more frequent meals.
Avoid lying down immediately after eating.
Elevate the head of your bed if you experience nighttime GERD symptoms.
Quit smoking.