Medicine Information

Ethibion

Name: Ethibion
Brand: Ethibion
Rating: 4.5 (117 reviews)

Tablet100 mgVitamins, B-group VitaminsATC: A11DA01

Generic Name

Thiamine Hydrochloride (Vitamin B1)

Manufacturer

Renata Limited

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
ethibion 100 mg tablet	৳ 7.00	৳ 70.00

Description

Overview of the medicine

Ethibion 100 mg Tablet contains Thiamine Hydrochloride (Vitamin B1), an essential water-soluble vitamin necessary for carbohydrate metabolism, nerve function, and cardiovascular health. It is used to prevent and treat Thiamine deficiency.

Uses & Indications

Prevention and treatment of Thiamine deficiency (Beri-beri)

Wernicke-Korsakoff syndrome (as part of therapy)

Nutritional support in conditions like alcoholism, malabsorption, and chronic illnesses

Thiamine-responsive metabolic disorders

Dosage

Adults

For Thiamine deficiency: 50-100 mg orally once daily. For severe deficiency or Wernicke-Korsakoff, higher doses may be prescribed by a physician.

Elderly

Similar to adult dosage; no specific adjustment usually needed unless significant renal impairment is present.

Renal_impairment

No specific dose adjustment is generally required, but caution is advised in severe renal impairment.

How to Take

Ethibion 100 mg Tablet should be taken orally, with or without food, as directed by a healthcare professional. Swallow the tablet whole with water.

Mechanism of Action

Thiamine is converted to its active form, Thiamine Pyrophosphate (TPP), which acts as a coenzyme in several metabolic pathways, particularly in carbohydrate metabolism (e.g., pyruvate dehydrogenase complex and alpha-ketoglutarate dehydrogenase complex). It is crucial for energy production and nerve impulse transmission.

Pharmacokinetics

Onset

Rapid after oral administration, with effects observed relatively quickly in addressing deficiency.

Excretion

Excreted primarily by the kidneys. Excess thiamine, beyond tissue saturation, is excreted unchanged in the urine.

Half life

Plasma half-life is approximately 98 minutes, but biological half-life in tissues is longer, ranging from 9 to 18 days.

Absorption

Readily absorbed from the gastrointestinal tract, primarily in the duodenum. Absorption involves active transport at lower concentrations and passive diffusion at higher concentrations.

Metabolism

Metabolized in the liver to its active form, thiamine pyrophosphate (TPP), and other metabolites.

Side Effects

Contraindications

Hypersensitivity to Thiamine or any component of the formulation.

Drug Interactions

Alcohol

Chronic alcohol consumption inhibits thiamine absorption and metabolism, increasing the risk of deficiency.

Diuretics (e.g., Furosemide)

May increase urinary excretion of thiamine, potentially leading to deficiency.

Storage

Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

Thiamine is a water-soluble vitamin, and excess amounts are generally excreted by the kidneys. Acute toxicity is very rare with oral administration. In extremely high parenteral doses, symptoms like headache, nausea, and irritability have been reported, but are not expected with oral tablets.

Pregnancy & Lactation

Thiamine is essential during pregnancy and lactation. Recommended daily allowances should be met. High doses should only be taken under medical supervision.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 x 10 tablets (100 tablets in a box)

Shelf Life

Typically 2-3 years from the date of manufacture.

Availability

Pharmacies, drugstores

Approval Status

Approved (as a vitamin supplement)

Patent Status

Generic

WHO Essential Medicine

Yes

Clinical Trials

Numerous clinical trials have established the efficacy of thiamine supplementation in preventing and treating thiamine deficiency, particularly in high-risk populations like alcoholics and those with malabsorption syndromes.

Lab Monitoring

Thiamine levels (in cases of suspected severe deficiency or malabsorption)
Red blood cell transketolase activity (functional measure of thiamine status)

Doctor Notes

Crucial for patients with alcoholism, as they often have severe thiamine deficiency.
Administer parenterally in acute Wernicke-Korsakoff syndrome for faster action.
Advise patients on dietary sources of thiamine.

Patient Guidelines

Take the tablet exactly as prescribed or as directed on the label.
Do not exceed the recommended dosage without consulting a doctor.
Inform your doctor about all other medications, supplements, and herbal products you are taking.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

Ethibion 100 mg Tablet is not known to affect the ability to drive or operate machinery.

Lifestyle Advice

Maintain a balanced diet rich in whole grains, legumes, nuts, and lean meats to ensure adequate thiamine intake.
Limit alcohol consumption, as it can deplete thiamine stores.