Medicine Information

Etovan

Name: Etovan
Brand: Etovan
Rating: 4.5 (117 reviews)

Tablet60 mgNon-steroidal Anti-inflammatory Drug (NSAID)ATC: M01AB08

Generic Name

Etodolac

Manufacturer

ACME Laboratories Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
etovan 60 mg tablet	৳ 6.50	৳ 65.00

Description

Overview of the medicine

Etovan 60 mg Tablet contains Etodolac, a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, inflammation, and stiffness caused by various conditions like osteoarthritis, rheumatoid arthritis, and other acute pain conditions.

Uses & Indications

Osteoarthritis

Rheumatoid arthritis

Juvenile rheumatoid arthritis

Acute pain (e.g., dental pain, post-operative pain)

Dysmenorrhea

Dosage

Adults

The usual adult dosage for Etodolac can range from 200-400 mg two to three times daily, or 400-600 mg twice daily. For 60 mg tablets, dosage should be strictly as prescribed by a physician based on individual needs and response, likely in combination or for specific low-dose regimens.

Elderly

Lower doses may be required, and patients should be monitored for adverse effects due to increased risk.

Renal_impairment

Reduced dosage or extended dosing intervals may be necessary. Caution is advised, and renal function should be monitored.

How to Take

Take the tablet orally with a full glass of water, preferably with food or milk to minimize gastrointestinal upset. Do not crush, chew, or break the tablet.

Mechanism of Action

Etodolac works by inhibiting cyclooxygenase (COX) enzymes, particularly COX-2, which are involved in the synthesis of prostaglandins. Prostaglandins are compounds in the body that cause pain, inflammation, and fever. By reducing prostaglandin production, Etodolac helps to alleviate these symptoms.

Pharmacokinetics

Onset

Analgesic effects typically begin within 30-60 minutes.

Excretion

Primarily excreted in the urine (approx. 75%) as metabolites, with a small amount in feces.

Half life

Approximately 6-7 hours.

Absorption

Well absorbed orally, with peak plasma concentrations reached within 1-2 hours.

Metabolism

Extensively metabolized in the liver via hydroxylation and glucuronidation.

Side Effects

Contraindications

Hypersensitivity to Etodolac, aspirin, or other NSAIDs
History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
Active gastrointestinal bleeding or peptic ulcer disease
Severe heart failure
Severe renal or hepatic impairment
Third trimester of pregnancy

Drug Interactions

Lithium

Increased plasma lithium levels, leading to toxicity.

Cyclosporine

Increased risk of nephrotoxicity.

Methotrexate

Increased methotrexate levels, enhancing toxicity.

Corticosteroids

Increased risk of gastrointestinal ulceration or bleeding.

ACE inhibitors/ARBs

Reduced antihypertensive effect; increased risk of renal impairment.

Diuretics (e.g., Furosemide)

Reduced diuretic and antihypertensive effects; increased risk of renal impairment.

Anticoagulants (e.g., Warfarin)

Increased risk of bleeding.

Antiplatelet agents (e.g., Aspirin, Clopidogrel)

Increased risk of gastrointestinal bleeding.

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose may include drowsiness, lethargy, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Management involves symptomatic and supportive care. Gastric lavage and/or activated charcoal may be considered if ingested recently.

Pregnancy & Lactation

Etodolac should be avoided during the third trimester of pregnancy due to potential harm to the fetus and complications during delivery. During the first and second trimesters, use only if the potential benefit justifies the potential risk to the fetus. It is not recommended during breastfeeding as it may pass into breast milk.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

Blister pack of 10 tabletsBlister pack of 30 tablets

Shelf Life

2 to 3 years from the date of manufacture.

Availability

Available in pharmacies and hospitals

Approval Status

Approved by regulatory authorities

Patent Status

Generic available (off-patent)

Clinical Trials

Etodolac has undergone extensive clinical trials demonstrating its efficacy and safety in various pain and inflammatory conditions. Specific trials for a 60 mg dose would depend on its specific formulation and intended use.

Lab Monitoring

Complete blood count (CBC) with long-term use
Renal function tests (e.g., Creatinine, BUN) periodically
Liver function tests (e.g., AST, ALT) periodically

Doctor Notes

Counsel patients on NSAID risks, especially GI and CV events.
Consider lowest effective dose for shortest duration possible.
Monitor renal function, liver enzymes, and CBC during prolonged therapy.
Caution in patients with a history of hypertension, heart failure, or fluid retention.

Patient Guidelines

Take with food or milk to reduce stomach upset.
Do not exceed the prescribed dose.
Report any unusual bleeding, persistent stomach pain, or dark stools immediately.
Avoid alcohol while taking this medicine.
Inform your doctor about all other medications you are taking.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

Etodolac may cause dizziness or drowsiness. Patients should be cautious when driving or operating machinery until they know how the medicine affects them.

Lifestyle Advice

Maintain a healthy lifestyle, including regular exercise and a balanced diet, to support overall health and manage chronic conditions.
Avoid smoking and excessive alcohol consumption, especially during treatment with Etodolac.