Medicine Information

Fevedol

Name: Fevedol
Brand: Fevedol
Rating: 4.5 (117 reviews)

Tablet325 mgAnalgesic, AntipyreticATC: N02BE01

Generic Name

Paracetamol (Acetaminophen)

Manufacturer

Local Pharma Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
fevedol 325 mg tablet	৳ 6.00	৳ 60.00

Description

Overview of the medicine

Fevedol 325 mg Tablet is an analgesic and antipyretic medication used for relief of mild to moderate pain and fever.

Uses & Indications

Relief of mild to moderate pain (e.g., headache, toothache, muscle pain, menstrual pain)

Reduction of fever

Dosage

Adults

One to two 325 mg tablets every 4-6 hours as needed. Maximum 4000 mg (12 tablets) in 24 hours.

Elderly

Same as adult dosage, but caution with hepatic or renal impairment.

Renal_impairment

Dosage interval may need to be extended. Consult a physician.

How to Take

Oral administration. Can be taken with or without food. Do not exceed the recommended dose.

Mechanism of Action

Paracetamol inhibits prostaglandin synthesis primarily in the central nervous system, leading to its analgesic and antipyretic effects. It has weak anti-inflammatory properties.

Pharmacokinetics

Onset

30-60 minutes for analgesic/antipyretic effect.

Excretion

Mainly renal as glucuronide and sulfate conjugates; less than 5% excreted unchanged.

Half life

1-4 hours, prolonged in liver dysfunction.

Absorption

Readily absorbed from the gastrointestinal tract, peak plasma concentrations occur within 30-60 minutes.

Metabolism

Primarily hepatic, conjugated with glucuronic acid and sulfate. A small amount is metabolized via CYP2E1 to a toxic intermediate, N-acetyl-p-benzoquinone imine (NAPQI), which is detoxified by glutathione.

Side Effects

Contraindications

Known hypersensitivity to paracetamol or any component of the formulation
Severe hepatic impairment

Drug Interactions

Alcohol

Increased risk of hepatotoxicity, especially with chronic excessive alcohol consumption.

Warfarin

May enhance the anticoagulant effect of warfarin, increasing bleeding risk with prolonged use of high doses.

Cholestyramine

May decrease paracetamol absorption if taken within 1 hour.

Metoclopramide, Domperidone

May increase paracetamol absorption.

Storage

Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

Symptoms include nausea, vomiting, abdominal pain, sweating, and liver failure. Immediate medical attention is crucial. Treatment includes activated charcoal and N-acetylcysteine (NAC).

Pregnancy & Lactation

Considered safe for use during pregnancy and lactation at recommended doses, but consult a doctor.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets per strip100 tablets per box

Shelf Life

Usually 2-3 years from manufacturing date.

Availability

Pharmacies, drugstores

Approval Status

Approved by regulatory bodies (e.g., DGDA)

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Extensively studied and widely used for decades. Most clinical trials focus on specific populations or new formulations.

Lab Monitoring

Liver function tests (in cases of overdose or chronic high dose use)
Renal function tests (in patients with pre-existing renal impairment)

Doctor Notes

Advise patients on maximum daily dose to prevent liver damage.
Caution in patients with pre-existing liver disease or chronic alcohol use.
Monitor for signs of allergic reactions.

Patient Guidelines

Do not exceed the stated dose.
Do not take with other paracetamol-containing products.
Consult a doctor if symptoms persist for more than 3 days (fever) or 5 days (pain).

Missed Dose Advice

If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.