Medicine Information

Fexonor

Name: Fexonor
Brand: Fexonor
Rating: 4.5 (117 reviews)

Tablet180 mgAntihistaminesATC: R06AE07

Generic Name

Fexofenadine Hydrochloride

Manufacturer

Assumed: Incepta Pharmaceuticals Ltd.

Country

Assumed: Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
fexonor 180 mg tablet	৳ 10.00	৳ 100.00

Description

Overview of the medicine

Fexonor 180 mg Tablet contains Fexofenadine Hydrochloride, a non-sedating antihistamine used to relieve symptoms of seasonal allergic rhinitis and chronic idiopathic urticaria (hives). It helps reduce sneezing, runny nose, itchy watery eyes, and itchy skin.

Uses & Indications

Relief of symptoms associated with seasonal allergic rhinitis in adults and children 12 years and older.

Treatment of uncomplicated skin manifestations of chronic idiopathic urticaria in adults and children 12 years and older.

Dosage

Adults

Seasonal Allergic Rhinitis: 180 mg once daily. Chronic Idiopathic Urticaria: 180 mg once daily.

Elderly

No dosage adjustment is generally required for elderly patients, but monitoring of renal function is advisable.

Renal_impairment

For patients with impaired renal function, the recommended starting dose is 60 mg once daily. Consult a doctor for specific dosage.

How to Take

Take orally with water, preferably before a meal. Do not take with fruit juices (grapefruit, orange, apple) as they may reduce absorption.

Mechanism of Action

Fexofenadine is a selective peripheral H1-receptor antagonist. It competitively binds to H1 receptors, blocking the action of histamine, which is responsible for allergic symptoms. Unlike older antihistamines, it does not readily cross the blood-brain barrier, resulting in minimal to no sedation.

Pharmacokinetics

Onset

Within 1 hour.

Excretion

Primarily excreted unchanged in feces (80%) and urine (11%) via biliary and renal routes.

Half life

Approximately 11 to 15 hours.

Absorption

Rapidly absorbed after oral administration. Peak plasma concentrations are reached in approximately 1 to 3 hours.

Metabolism

Minimally metabolized; about 5% is metabolized by the liver.

Side Effects

Contraindications

Hypersensitivity to fexofenadine or any component of the formulation.
Children under 6 years of age for the 180 mg strength.

Drug Interactions

Erythromycin and Ketoconazole

Can increase plasma levels of fexofenadine. Monitor for increased side effects.

Antacids containing Aluminum or Magnesium

Reduce fexofenadine absorption. Take fexofenadine at least 2 hours before or after these antacids.

Storage

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose may include drowsiness, dizziness, dry mouth, and nausea. In case of overdose, symptomatic and supportive treatment is recommended. Hemodialysis is not effective in removing fexofenadine from blood.

Pregnancy & Lactation

Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. Not recommended during lactation as fexofenadine is excreted in breast milk.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets per pack30 tablets per pack

Shelf Life

Typically 24 to 36 months from manufacturing date.

Availability

Available in pharmacies worldwide.

Approval Status

Approved by FDA/DGDA (or equivalent regulatory bodies)

Patent Status

Generic available, original patent expired

WHO Essential Medicine

Yes

Clinical Trials

Fexofenadine has undergone extensive clinical trials demonstrating its efficacy and safety in treating seasonal allergic rhinitis and chronic idiopathic urticaria, showing superior non-sedating properties compared to older antihistamines.

Lab Monitoring

No specific routine lab monitoring is required for fexofenadine.

Doctor Notes

Fexofenadine 180 mg is a highly effective, non-sedating antihistamine for allergic rhinitis and urticaria.
Advise patients on fruit juice interactions and timing with antacids.
Consider lower doses in patients with renal impairment.

Patient Guidelines

Do not exceed the recommended dose.
Avoid taking with fruit juices (grapefruit, orange, apple).
Inform your doctor or pharmacist about all other medications you are taking, especially antacids.
If symptoms do not improve or worsen, consult your doctor.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.

Driving Precautions

Although fexofenadine is a non-sedating antihistamine, individual responses can vary. Patients should assess their response to the drug before driving or operating machinery.