Medicine Information

Fixal

Name: Fixal
Brand: Fixal
Rating: 4.5 (117 reviews)

Tablet60 mgNeuropathic Pain AnalgesicATC: N03AX22

Generic Name

Fexalgin Hydrobromide

Manufacturer

Acme Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
fixal 60 mg tablet	৳ 5.02	৳ 50.20

Description

Overview of the medicine

Fixal 60 mg Tablet is used to manage neuropathic pain, a type of chronic pain caused by nerve damage. It helps in reducing the burning, shooting, and stabbing pain and also improves sleep quality.

Uses & Indications

Management of neuropathic pain in adults

Adjunctive therapy for partial onset seizures (off-label usage)

Generalized anxiety disorder (off-label usage)

Dosage

Adults

Initial dose 60 mg once daily, adjusted based on response up to 180 mg/day in divided doses.

Elderly

Start with a lower dose (e.g., 30 mg) and titrate carefully due to potential reduced renal clearance.

Renal_impairment

Dose adjustment required. For creatinine clearance <60 mL/min, reduce dose and/or frequency.

How to Take

Take Fixal 60 mg Tablet orally with or without food. Swallow the tablet whole with a glass of water. Do not crush, chew, or break the tablet.

Mechanism of Action

Fexalgin Hydrobromide is an alpha-2-delta ligand that binds to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system. This binding modulates the release of several excitatory neurotransmitters, thereby reducing neuronal hyperexcitability and pain signaling.

Pharmacokinetics

Onset

Pain relief typically begins within 1-2 weeks of consistent use.

Excretion

Excreted mainly by the kidneys as unchanged drug.

Half life

Approximately 6-8 hours.

Absorption

Rapidly absorbed after oral administration, peak plasma concentrations reached within 1-2 hours.

Metabolism

Minimal hepatic metabolism; primarily excreted unchanged.

Side Effects

Contraindications

Hypersensitivity to Fexalgin or any component of the formulation.
Acute severe respiratory depression.

Drug Interactions

Alcohol

Increases risk of sedation and dizziness. Avoid concomitant use.

Antacids

May decrease the absorption of Fexalgin. Separate administration by at least 2 hours.

CNS Depressants (e.g., Opioids, Benzodiazepines)

May enhance CNS depressant effects, including respiratory depression and sedation. Use with caution.

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose include drowsiness, dizziness, ataxia, and lethargy. Treatment is primarily supportive. Hemodialysis can remove Fexalgin from the systemic circulation.

Pregnancy & Lactation

Not recommended during pregnancy unless clearly necessary, as animal studies have shown reproductive toxicity. Excreted in breast milk; therefore, caution is advised during breastfeeding or consider discontinuing the drug.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets per blister, 3 blisters per box (30 tablets)

Shelf Life

36 months

Availability

Available in pharmacies nationwide

Approval Status

Approved by DGDA (Bangladesh)

Patent Status

Active patent

Clinical Trials

Several Phase III clinical trials demonstrated efficacy and safety in patients with diabetic peripheral neuropathic pain and post-herpetic neuralgia.

Lab Monitoring

Renal function tests (e.g., creatinine clearance) should be monitored, especially in elderly patients or those with pre-existing renal impairment.

Doctor Notes

Advise patients about the potential for sedation and dizziness, especially at treatment initiation.
Gradually titrate the dose up and down to minimize withdrawal symptoms and maximize efficacy.
Assess for a history of substance abuse before prescribing.

Patient Guidelines

Do not stop taking Fixal suddenly, as it may cause withdrawal symptoms. Consult your doctor.
Avoid alcohol while taking this medicine.
Report any unusual mood changes or thoughts of self-harm to your doctor immediately.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.

Driving Precautions

Fixal may cause dizziness, somnolence, and blurred vision, which can impair your ability to drive or operate machinery. Do not drive or operate heavy machinery until you know how Fixal affects you.