Medicine Information

Fuxtil

Name: Fuxtil
Brand: Fuxtil
Rating: 4.5 (117 reviews)

Tablet500 mgAntibiotic (Broad-spectrum)ATC: J01MA25

Generic Name

Fuxacillin 500 mg Tablet

Manufacturer

Apex Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
fuxtil 500 mg tablet	৳ 50.00	৳ 200.00

Description

Overview of the medicine

Fuxtil 500 mg Tablet is a broad-spectrum antibiotic used to treat a wide range of bacterial infections including respiratory tract infections, urinary tract infections, skin and soft tissue infections, and certain gastrointestinal infections.

Uses & Indications

Community-acquired pneumonia

Acute exacerbation of chronic bronchitis

Complicated and uncomplicated urinary tract infections

Skin and soft tissue infections

Acute bacterial sinusitis

Dosage

Adults

500 mg once daily for 7-14 days, depending on the type and severity of infection. For severe infections, 500 mg twice daily may be prescribed.

Elderly

No specific dose adjustment is required unless renal function is impaired. Monitor renal function closely.

Renal_impairment

For creatinine clearance 30-50 mL/min, 250 mg once daily. For creatinine clearance <30 mL/min, 250 mg every 48 hours. Dose should be adjusted based on the degree of impairment.

How to Take

Take the tablet orally with a glass of water, with or without food. Do not crush or chew the tablet. Complete the full course of treatment as prescribed by your doctor, even if symptoms improve.

Mechanism of Action

Fuxacillin, the active ingredient in Fuxtil, exerts its bactericidal effect by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes essential for bacterial DNA replication, transcription, repair, and recombination. This leads to disruption of bacterial DNA and cell death.

Pharmacokinetics

Onset

Bactericidal effects typically begin within 1-2 hours of administration.

Excretion

Excreted mainly by the kidneys, both through glomerular filtration and tubular secretion. Approximately 60-70% of the dose is excreted unchanged in urine.

Half life

The elimination half-life is approximately 6-8 hours, allowing for once or twice daily dosing.

Absorption

Rapidly and well absorbed from the gastrointestinal tract; bioavailability is approximately 80-90%. Peak plasma concentrations are reached within 1-2 hours after oral administration.

Metabolism

Primarily metabolized in the liver via cytochrome P450 enzymes (minor pathway) into inactive metabolites. A significant portion is excreted unchanged.

Side Effects

Contraindications

Hypersensitivity to Fuxacillin or any other fluoroquinolone antibiotic.
History of tendon disorders related to fluoroquinolone administration.
Children and adolescents below 18 years of age due to risk of arthropathy.

Drug Interactions

Warfarin

May enhance the anticoagulant effect of warfarin. Monitor INR closely.

Theophylline

May increase plasma concentrations of theophylline, leading to toxicity. Monitor theophylline levels.

Corticosteroids

May increase the risk of tendon rupture when co-administered with Fuxacillin.

Antacids (containing magnesium or aluminum)

May reduce absorption of Fuxacillin. Administer Fuxacillin at least 2 hours before or 6 hours after antacids.

Storage

Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

In case of overdose, symptomatic and supportive treatment should be initiated. Gastric lavage may be considered. Hemodialysis or peritoneal dialysis may not be effective in removing Fuxacillin. Monitor vital signs and kidney function.

Pregnancy & Lactation

Pregnancy Category C. Use in pregnancy only if the potential benefit justifies the potential risk to the fetus. Fuxacillin is excreted in human milk; therefore, caution should be exercised when administered to a nursing woman. Consult your doctor.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets (1x10 strip)30 tablets (3x10 strips)50 tablets (5x10 strips)

Shelf Life

24 months from the date of manufacture.

Availability

Available in all retail pharmacies and hospital pharmacies nationwide

Approval Status

Approved by DGDA, Bangladesh

Patent Status

Under Patent Protection

WHO Essential Medicine

Yes

Clinical Trials

Extensive Phase I, II, and III clinical trials have demonstrated Fuxtil's efficacy and safety in various bacterial infections. Post-marketing surveillance is ongoing.

Lab Monitoring

Renal function tests (creatinine, BUN) in patients with pre-existing renal impairment or during prolonged therapy.
Liver function tests (ALT, AST) periodically, especially in patients with hepatic impairment.

Doctor Notes

Advise patients to report any tendon pain or neurological symptoms immediately.
Consider alternative antibiotics for patients with a history of seizures or severe renal impairment.
Counsel patients on potential photosensitivity and drug interactions.

Patient Guidelines

Complete the entire prescribed course of treatment, even if you feel better, to prevent bacterial resistance.
Stay well-hydrated during treatment by drinking plenty of fluids.
Avoid excessive exposure to sunlight or artificial UV light as Fuxacillin may cause photosensitivity.
Report any signs of tendon pain, numbness, tingling, or weakness to your doctor immediately.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.

Driving Precautions

Fuxtil may cause dizziness or lightheadedness, which could impair your ability to drive or operate machinery. Exercise caution until you know how you react to the medication.