Medicine Information

Benzathine Penicillin G

Name: Benzathine Penicillin G
Brand: Benzathine Penicillin G
Rating: 4.5 (117 reviews)

Powder for suspension for intramuscular injection600,000 IU (6 Lakh units)Antibiotics (Beta-lactam), PenicillinsATC: J01CE08

Generic Name

Benzathine Penicillin G 600,000 units injection

Manufacturer

Example Pharma Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
g benzathine penicil 6 lac injection	৳ 15.00	N/A

Description

Overview of the medicine

Benzathine Penicillin G is a long-acting form of penicillin used to treat various bacterial infections, primarily syphilis and as prophylaxis for rheumatic fever. It is administered via deep intramuscular injection.

Uses & Indications

Treatment of Syphilis (primary, secondary, latent, and tertiary)

Prophylaxis of Rheumatic Fever

Treatment of Streptococcal pharyngitis

Treatment of Yaws and Pinta

Dosage

Adults

Syphilis: Primary, secondary, latent (<1 year) - 2.4 million units IM single dose. Latent (>1 year) or tertiary - 2.4 million units IM weekly for 3 weeks. Rheumatic fever prophylaxis: 1.2 million units IM every 3-4 weeks. Streptococcal pharyngitis: 1.2 million units IM single dose.

Elderly

Similar to adult dosage, but caution with renal impairment.

Renal_impairment

No specific dose adjustment for mild to moderate impairment, but careful monitoring is advised for severe renal impairment due to potential accumulation.

How to Take

Administer by deep intramuscular injection only, preferably in the upper outer quadrant of the buttock. Do not administer intravenously, subcutaneously, or intra-arterially.

Mechanism of Action

It inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bactericidal effects against susceptible organisms.

Pharmacokinetics

Onset

Peak plasma concentrations are achieved within 12-24 hours.

Excretion

Excreted primarily unchanged by the kidneys.

Half life

Approximately 7-14 days, due to slow absorption and release.

Absorption

Slowly and completely absorbed from the intramuscular injection site, providing prolonged detectable blood levels.

Metabolism

Minimal metabolism.

Side Effects

Contraindications

Known hypersensitivity to penicillin or any other beta-lactam antibiotics (e.g., cephalosporins)
Intravenous administration (can cause cardio-respiratory arrest and death)

Drug Interactions

Probenecid

Decreases the renal tubular secretion of penicillin, prolonging its half-life and increasing serum concentrations.

Methotrexate

Reduced excretion of methotrexate, increasing its toxicity.

Tetracyclines

May antagonize the bactericidal effect of penicillin.

Oral Contraceptives

May reduce efficacy of oral contraceptives (though controversial).

Storage

Store below 30°C in a dry place, protected from light. Do not freeze.

Overdose

Overdose is rare due to single-dose administration. Symptoms may include neuromuscular hyperexcitability or seizures in very high doses, especially with renal impairment. Management is symptomatic and supportive, including hemodialysis if severe.

Pregnancy & Lactation

Pregnancy Category B. Generally considered safe during pregnancy. Penicillins are excreted in breast milk in small amounts; generally considered safe for breastfeeding infants, but monitor for allergic reactions in the infant.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

1 vial of 600,000 IU1 vial of 1.2 million IU

Shelf Life

2-3 years (unreconstituted powder) when stored properly. Reconstituted suspension should be used immediately.

Availability

Available in hospitals and pharmacies

Approval Status

Approved for general use worldwide

Patent Status

Patent expired, generic available

WHO Essential Medicine

Yes

Clinical Trials

Extensive historical clinical data supports the efficacy of Benzathine Penicillin G in its approved indications. Ongoing surveillance monitors for resistance and adverse effects.

Lab Monitoring

Periodic renal function tests during prolonged therapy
Complete blood count (CBC) if signs of hematopoietic toxicity occur

Doctor Notes

Emphasize IM administration only, never IV, due to severe adverse reaction risk.
Assess penicillin allergy history thoroughly before administration.
Counsel patients on potential Jarisch-Herxheimer reaction during syphilis treatment.

Patient Guidelines

Inform your doctor about any allergies, especially to penicillins or cephalosporins.
Report any signs of allergic reaction (rash, itching, difficulty breathing) immediately.
Ensure the injection is given intramuscularly only.

Missed Dose Advice

As this is usually a single or infrequent dose administered by a healthcare professional, missing a dose is unlikely. If a scheduled dose is missed, contact your doctor immediately for rescheduling.

Driving Precautions

Benzathine Penicillin G is not known to impair the ability to drive or operate machinery. However, if allergic reactions or dizziness occur, avoid such activities.