Medicine Information

Gabantin

Name: Gabantin
Brand: Gabantin
Rating: 4.5 (117 reviews)

Tablet100 mgAnticonvulsants, Neuropathic pain agentsATC: N03AX12

Generic Name

Gabapentin

Manufacturer

Healthcare Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
gabantin 100 mg tablet	৳ 6.02	৳ 60.20

Description

Overview of the medicine

Gabantin 100 mg Tablet is used to treat epilepsy (seizures) and neuropathic pain (nerve pain). It works by decreasing the abnormal excitement in the brain.

Uses & Indications

Adjunctive therapy for partial seizures with or without secondary generalization in adults and children aged 12 years and above.

Management of postherpetic neuralgia (nerve pain following shingles) in adults.

Restless Legs Syndrome (RLS) in adults.

Dosage

Adults

For neuropathic pain: Initially 300 mg on day 1, 300 mg twice daily on day 2, and 300 mg three times daily on day 3, then titrated up to a maximum of 3600 mg/day in three divided doses. For epilepsy: Initially 300 mg three times daily, adjusted according to response, up to 1200 mg/day; maximum 2400-3600 mg/day.

Elderly

Reduced dosage and careful titration advised due to potential age-related decrease in renal function.

Renal_impairment

Dosage must be adjusted based on creatinine clearance. For CrCl 30-59 mL/min, maximum 700 mg/day; for CrCl 15-29 mL/min, maximum 400 mg/day.

How to Take

Gabantin 100 mg Tablet should be taken orally, with or without food. It is recommended to swallow the tablet whole with water. Do not crush or chew.

Mechanism of Action

Gabapentin is thought to exert its effect by modulating the activity of voltage-gated calcium channels, particularly the alpha-2-delta subunit, reducing the release of excitatory neurotransmitters. It does not bind to GABA receptors directly.

Pharmacokinetics

Onset

Onset of action for pain relief can be days to weeks; for seizures, it's typically within days of achieving therapeutic levels.

Excretion

Excreted unchanged by the kidneys. Renal clearance is directly proportional to creatinine clearance.

Half life

Approximately 5 to 7 hours in adults with normal renal function.

Absorption

Oral absorption is dose-dependent and saturable, decreasing with increasing doses. Bioavailability ranges from 27% to 60%.

Metabolism

Not significantly metabolized in humans. It does not induce hepatic microsomal enzymes.

Side Effects

Contraindications

Hypersensitivity to gabapentin or any component of the formulation.

Drug Interactions

Antacids

May decrease the bioavailability of gabapentin; take gabapentin at least 2 hours after antacid administration.

Opioids (e.g., Morphine)

May increase gabapentin concentrations and enhance CNS depressant effects, leading to increased sedation and respiratory depression. Monitor patients for signs of CNS depression.

CNS Depressants (e.g., Alcohol, Benzodiazepines)

Concurrent use may enhance CNS depressant effects of gabapentin. Avoid alcohol and use with caution with other CNS depressants.

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose include dizziness, double vision, slurred speech, drowsiness, lethargy, and diarrhea. Treatment is primarily supportive. Hemodialysis can be used for severe cases, as gabapentin is dialyzable.

Pregnancy & Lactation

Pregnancy Category C. Gabapentin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted in human milk; caution should be exercised when gabapentin is administered to a nursing woman.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

30 tablets (3 x 10's blister pack)

Shelf Life

Typically 2 to 3 years from the date of manufacture, when stored under recommended conditions.

Availability

Available in pharmacies and hospitals

Approval Status

FDA and DGDA approved

Patent Status

Off-patent (Generic available)

WHO Essential Medicine

Yes

Clinical Trials

Gabapentin has undergone extensive clinical trials for its efficacy and safety in various indications, including partial seizures and postherpetic neuralgia. Ongoing research continues to explore its potential uses and long-term effects.

Lab Monitoring

Monitor renal function, especially in elderly patients or those with kidney impairment, for appropriate dose adjustment. No routine specific lab monitoring is generally required for gabapentin in patients with normal renal function.

Doctor Notes

Emphasize slow titration of gabapentin to minimize adverse effects and optimize efficacy.
Adjust dose in renal impairment. Monitor for signs of suicidal ideation or unusual behavioral changes, especially at the initiation of therapy or during dose changes.
Educate patients on the importance of not discontinuing gabapentin abruptly.

Patient Guidelines

Do not stop taking Gabantin abruptly without consulting your doctor, as it may cause withdrawal seizures or worsening of symptoms.
Report any unusual changes in mood, behavior, or suicidal thoughts to your doctor immediately.
Avoid driving or operating heavy machinery until you know how the medicine affects you, as it may cause dizziness or drowsiness.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Driving Precautions

Gabantin 100 mg Tablet may cause dizziness, drowsiness, and blurred vision. Patients should be advised not to drive or operate hazardous machinery until they are reasonably certain that gabapentin does not adversely affect their ability to engage in such activities.

Lifestyle Advice

Avoid alcohol consumption while taking gabapentin, as it can increase drowsiness and dizziness.
Maintain a regular dosing schedule to ensure consistent blood levels of the medication and maximize its effectiveness.