Medicine Information

Gatiflox

Name: Gatiflox
Brand: Gatiflox
Rating: 4.5 (117 reviews)

Ophthalmic Solution (Eye Drop)0.3% w/vOphthalmic AntibioticsATC: S01AE08

Generic Name

Gatifloxacin 0.3% Ophthalmic Solution

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

Loading images...

Price Details

Current market pricing information

Variant	Unit Price	Strip Price
gatiflox 03 eye drop	৳ 100.00	N/A

Description

Overview of the medicine

Gatifloxacin 0.3% eye drop is an ophthalmic antibiotic used to treat bacterial conjunctivitis caused by susceptible strains of microorganisms. It belongs to the fluoroquinolone class.

Uses & Indications

Bacterial conjunctivitis

Corneal ulcers caused by susceptible bacteria

Dosage

Adults

Instill 1 drop into the affected eye(s) every 2 hours while awake, up to 8 times a day, for the first 2 days, then 1 drop 4 times a day for the next 5 days.

Elderly

No dosage adjustment necessary.

Renal_impairment

No dosage adjustment necessary as systemic absorption is minimal.

How to Take

For ophthalmic use only. Tilt head back, pull down the lower eyelid to form a pouch, instill the drop, and close the eye gently. Do not touch the dropper tip to any surface.

Mechanism of Action

Gatifloxacin, a fluoroquinolone, inhibits bacterial DNA gyrase and topoisomerase IV, essential enzymes involved in bacterial DNA replication, transcription, repair, and recombination. This leads to cell death.

Pharmacokinetics

Onset

Rapid onset of action, typically within hours for antibacterial effect.

Excretion

Primarily excreted unchanged in urine if absorbed systemically, but topical application leads to negligible systemic excretion.

Half life

Systemic half-life is around 7-8 hours, but topical application leads to very low systemic exposure. Ocular tissue concentrations are maintained for several hours.

Absorption

Minimal systemic absorption after topical ophthalmic administration. Peak plasma concentrations are generally below quantifiable limits.

Metabolism

Minimally metabolized systemically.

Side Effects

Contraindications

Hypersensitivity to gatifloxacin, other quinolones, or any component of the medication
Viral or fungal eye infections

Drug Interactions

Systemic medications

No significant systemic drug interactions expected due to minimal systemic absorption.

Other ophthalmic preparations

If using multiple eye drops, administer them at least 5 minutes apart.

Storage

Store at room temperature (20°C to 25°C), away from light and moisture. Do not freeze. Keep out of reach of children.

Overdose

Overdose with ophthalmic drops is unlikely due to the small amount of drug per drop and minimal systemic absorption. If topical overdose occurs, the eye can be rinsed with lukewarm water.

Pregnancy & Lactation

Pregnancy Category C. Use only if potential benefit outweighs risk. Caution advised during lactation; systemic absorption is minimal, but monitor infant for adverse effects.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

5 ml bottle10 ml bottle

Shelf Life

24-36 months

Availability

Pharmacies, Hospitals

Approval Status

Approved by major regulatory bodies

Patent Status

Generic available, patents expired

Clinical Trials

Gatifloxacin ophthalmic solution has undergone numerous clinical trials demonstrating its efficacy and safety in treating bacterial conjunctivitis and other ocular infections.

Lab Monitoring

Not typically required for ophthalmic use due to minimal systemic exposure.

Doctor Notes

Advise patients on proper instillation technique.
Emphasize completion of the full course to prevent recurrence and resistance.
Counsel on potential temporary blurred vision post-instillation.

Patient Guidelines

Do not wear contact lenses during treatment.
Wash hands before and after applying drops.
Avoid touching the dropper tip to prevent contamination.
Finish the full course of medication even if symptoms improve.

Missed Dose Advice

Apply the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not apply extra drops to make up for a missed dose.

Driving Precautions

May cause temporary blurred vision or discomfort after administration. Advise patients to wait until vision clears before driving or operating machinery.