Medicine Information

Hi-Fenac-TR

Name: Hi-Fenac-TR
Brand: Hi-Fenac-TR
Rating: 4.5 (117 reviews)

Capsule, Extended-Release100 mgNon-steroidal Anti-inflammatory Drugs (NSAIDs)ATC: M01AB05

Generic Name

Diclofenac Sodium Extended-Release 100 mg Capsule

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

Loading images...

Price Details

Current market pricing information

Variant	Unit Price	Strip Price
hi fenac tr 100 mg capsule	৳ 3.00	N/A

Description

Overview of the medicine

Hi-Fenac-TR 100 mg Capsule contains Diclofenac Sodium, a non-steroidal anti-inflammatory drug (NSAID) used for the long-term treatment of chronic pain and inflammation, such as in rheumatoid arthritis and osteoarthritis.

Uses & Indications

Rheumatoid arthritis

Osteoarthritis

Ankylosing spondylitis

Acute musculoskeletal disorders

Pain and inflammation post-surgery or trauma

Dosage

Adults

100 mg once daily, preferably with food. Max 100 mg/day.

Elderly

Use with caution; lower doses may be considered. Monitor renal function and for GI adverse effects.

Renal_impairment

Use with caution; dose reduction may be necessary. Avoid in severe renal impairment.

How to Take

Take the capsule whole with a glass of water, preferably during or after a meal. Do not chew, crush, or break the capsule, as it is an extended-release formulation.

Mechanism of Action

Diclofenac inhibits prostaglandin synthesis by reversibly inhibiting cyclooxygenase (COX-1 and COX-2) enzymes, thereby reducing inflammation, pain, and fever.

Pharmacokinetics

Onset

Pain relief usually within 1 hour, full anti-inflammatory effects may take several days.

Excretion

Excreted in urine (approx. 60%) and bile (approx. 35%) as conjugates of metabolites.

Half life

Approximately 1-2 hours for the parent compound; active metabolites have longer half-lives.

Absorption

Well absorbed from the GI tract; peak plasma concentrations reached in 2-3 hours for conventional forms, extended for TR formulations over several hours.

Metabolism

Extensively metabolized in the liver, primarily by hydroxylation and subsequent glucuronidation.

Side Effects

Contraindications

Hypersensitivity to diclofenac or other NSAIDs
Active gastrointestinal bleeding or ulcer
Severe heart failure
Severe renal or hepatic impairment
Third trimester of pregnancy
History of asthma, urticaria, or allergic reactions after aspirin or other NSAIDs

Drug Interactions

Lithium

Increased plasma lithium levels, leading to potential toxicity.

Warfarin

Increased risk of bleeding due to enhanced anticoagulant effect.

Diuretics

Reduced diuretic and antihypertensive effects; increased risk of renal impairment.

Methotrexate

Increased methotrexate toxicity due to reduced renal clearance.

Corticosteroids

Increased risk of gastrointestinal ulceration and bleeding.

ACE inhibitors/ARBs

Increased risk of renal impairment, especially in dehydrated or elderly patients.

Storage

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.

Overdose

Symptoms may include lethargy, drowsiness, nausea, vomiting, epigastric pain, GI bleeding, hypotension, respiratory depression, and coma. Management involves symptomatic and supportive care, gastric lavage, and activated charcoal if ingestion is recent.

Pregnancy & Lactation

Avoid in the third trimester of pregnancy due to the risk of premature closure of the fetal ductus arteriosus and renal dysfunction. Not recommended during breastfeeding as diclofenac passes into breast milk and may cause adverse effects in the infant.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 capsules/strip30 capsules/box

Shelf Life

Typically 24 to 36 months from the manufacturing date, depending on the specific formulation and manufacturer's guidelines.

Availability

Pharmacies and Hospitals

Approval Status

Approved by regulatory authorities (e.g., DGDA in Bangladesh)

Patent Status

Expired for generic formulation

WHO Essential Medicine

Yes

Clinical Trials

Diclofenac, including its extended-release formulations, has undergone extensive clinical trials supporting its efficacy and safety for its approved indications, particularly in the management of chronic inflammatory and painful conditions.

Lab Monitoring

Complete blood count (CBC) for signs of bleeding or anemia
Liver function tests (LFTs) periodically
Renal function tests (Creatinine, BUN) periodically
Blood pressure monitoring regularly, especially in hypertensive patients

Doctor Notes

Advise patients to take the lowest effective dose for the shortest duration consistent with individual patient treatment goals.
Monitor patients for signs of GI bleeding or cardiovascular adverse events, especially during long-term therapy.
Assess renal function regularly in patients on long-term therapy or with risk factors for renal impairment.
Counsel patients on the importance of taking the capsule whole without crushing or chewing.

Patient Guidelines

Take exactly as prescribed by your doctor and do not modify the dose without consultation.
Do not exceed the recommended dose to avoid serious side effects.
Report any unusual bleeding, bruising, black/tarry stools, or severe stomach pain immediately.
Avoid concomitant use of other NSAIDs or aspirin unless advised by a doctor.

Missed Dose Advice

If a dose is missed, take it as soon as you remember. If it's almost time for the next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to make up for a missed one.

Driving Precautions

Hi-Fenac-TR may cause dizziness, drowsiness, or visual disturbances. If you experience these effects, do not drive or operate machinery.

Lifestyle Advice

Avoid alcohol consumption, as it may increase the risk of gastrointestinal bleeding.
Maintain a healthy diet and stay well-hydrated.
Consult your doctor before taking any over-the-counter pain relievers or cold medicines.