Medicine Information

Ipical-M

Name: Ipical-M
Brand: Ipical-M
Rating: 4.5 (117 reviews)

TabletCalcium Carbonate 500 mg + Magnesium Hydroxide 250 mg + Vitamin D3 200 IUMineral and vitamin supplements, Bone healthATC: A12AX

Generic Name

Calcium Carbonate + Magnesium Hydroxide + Vitamin D3

Manufacturer

Acme Pharmaceuticals

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
ipical m tablet	৳ 6.00	৳ 180.00

Description

Overview of the medicine

A dietary supplement combining calcium, magnesium, and vitamin D3 to support bone health, muscle function, and overall well-being. It is often used to prevent and treat mineral deficiencies.

Uses & Indications

Prevention and treatment of calcium, magnesium, and vitamin D deficiencies

Support for bone health and prevention of osteoporosis

During pregnancy and lactation for adequate maternal and fetal/infant bone development

Postmenopausal women to help reduce bone loss

As an adjuvant therapy for rickets and osteomalacia

Dosage

Adults

Typically 1-2 tablets daily, or as directed by a physician. May be taken in divided doses.

Elderly

Same as adults, or adjust based on individual needs and renal function. Consultation with a physician is recommended.

Renal_impairment

Caution advised. Dosage adjustment may be necessary due to potential hypermagnesemia or hypercalcemia. Consult a physician.

How to Take

Take orally, preferably with meals to enhance absorption and reduce gastrointestinal upset. Swallow the tablet whole with water.

Mechanism of Action

Calcium is essential for bone mineralization, nerve impulse transmission, muscle contraction, and blood coagulation. Magnesium is a cofactor in many enzymatic reactions, vital for muscle and nerve function, protein synthesis, blood glucose control, and blood pressure regulation. Vitamin D3 facilitates intestinal absorption of calcium and phosphate, regulates bone remodeling, and maintains serum calcium and phosphate levels.

Pharmacokinetics

Onset

Effects are gradual and become evident over weeks to months, as this is a supplement for long-term physiological support.

Excretion

Calcium: Primarily renal, also fecal. Magnesium: Primarily renal. Vitamin D3: Metabolites excreted via bile and urine.

Half life

Calcium: Complex, depends on physiological demand. Magnesium: Not precisely defined for dietary intake. Vitamin D3: Approximately 15-30 days for cholecalciferol, its active metabolite calcitriol has a shorter half-life.

Absorption

Calcium: Absorbed primarily in the small intestine, efficiency depends on Vitamin D status. Magnesium: Absorbed mainly in the small intestine. Vitamin D3: Absorbed in the small intestine, requiring bile salts.

Metabolism

Calcium: Not metabolized in the classical sense, but incorporated into bone or excreted. Magnesium: Not metabolized. Vitamin D3: Hydroxylated in the liver to 25-hydroxyvitamin D (calcifediol) and then in the kidneys to 1,25-dihydroxyvitamin D (calcitriol).

Side Effects

Contraindications

Hypersensitivity to any component of the formulation
Hypercalcemia (high calcium levels in blood)
Hypermagnesemia (high magnesium levels in blood)
Severe renal impairment
Hypervitaminosis D (vitamin D toxicity)
History of or active kidney stones (nephrolithiasis)

Drug Interactions

Digoxin

Hypercalcemia may increase the risk of digoxin toxicity. Monitor closely.

Bisphosphonates

Reduced absorption when taken concurrently. Administer at least 30-60 minutes before or after calcium/magnesium.

Thiazide Diuretics

May increase serum calcium levels, increasing risk of hypercalcemia.

Thyroid Hormones (e.g., Levothyroxine)

Reduced absorption. Administer at least 4 hours apart.

Tetracycline and Fluoroquinolone Antibiotics

Calcium and magnesium can chelate these antibiotics, reducing their absorption. Administer at least 2-4 hours apart.

Storage

Store in a cool (below 30°C), dry place, away from direct sunlight and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose may include nausea, vomiting, constipation, abdominal pain, muscle weakness, polyuria (frequent urination), polydipsia (increased thirst), confusion, and in severe cases, kidney stones or cardiac arrhythmias. Management involves discontinuing the supplement, ensuring adequate hydration, and seeking immediate medical attention for severe symptoms.

Pregnancy & Lactation

Generally considered safe and often recommended for adequate intake during pregnancy and lactation to support maternal and fetal/infant bone health. However, use only under medical supervision to avoid excessive intake and potential adverse effects.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

3 x 10 tablets (30 tablets)5 x 10 tablets (50 tablets)

Shelf Life

24 months from the date of manufacture.

Availability

Pharmacies, supermarkets, online stores

Approval Status

Over-the-counter (OTC) supplement

Patent Status

Off-patent

Clinical Trials

Individual components (calcium, magnesium, vitamin D3) have extensive clinical trial data supporting their efficacy in bone health and mineral deficiency. Specific combination formulations like Ipical-M typically undergo bioavailability and bioequivalence studies rather than new large-scale efficacy trials.

Lab Monitoring

Serum calcium, magnesium, and vitamin D (25-hydroxyvitamin D) levels, especially in patients with suspected deficiency, during long-term high-dose therapy, or with pre-existing conditions (e.g., renal impairment).
Renal function tests (e.g., serum creatinine, eGFR) in patients with kidney impairment.

Doctor Notes

Assess patient's dietary intake and baseline vitamin/mineral levels before initiating therapy.
Advise patients on adequate fluid intake to minimize risk of constipation and kidney stone formation.
Consider potential drug interactions, especially with antibiotics, bisphosphonates, and thyroid hormones.
Monitor for signs of hypercalcemia or hypermagnesemia, particularly in patients with renal impairment or those on other medications affecting calcium/magnesium levels.

Patient Guidelines

Take the medicine exactly as prescribed or as directed on the label; do not exceed the recommended dose.
Swallow tablets whole with plenty of water.
Inform your doctor or pharmacist about all other medications and supplements you are taking.
Report any unusual or severe side effects to your healthcare provider.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.

Driving Precautions

Ipical-M Tablet is generally not expected to impair the ability to drive or operate machinery. However, if you experience dizziness or any other side effect that might affect your concentration, avoid these activities.

Lifestyle Advice

Maintain a balanced diet rich in calcium-containing foods (dairy, leafy greens) and vitamin D-rich foods (fatty fish, fortified foods).
Engage in regular weight-bearing exercise (e.g., walking, jogging) to support bone health.
Ensure adequate sun exposure (10-15 minutes, 2-3 times a week) for natural vitamin D synthesis, while also protecting against excessive UV radiation.