Medicine Information

Itogut

Name: Itogut
Brand: Itogut
Rating: 4.5 (117 reviews)

Tablet50 mgProkineticATC: A03FA07

Generic Name

Itopride Hydrochloride

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
itogut 50 mg tablet	৳ 6.00	৳ 60.00

Description

Overview of the medicine

Itogut 50 mg Tablet contains Itopride Hydrochloride, a prokinetic agent used to treat gastrointestinal symptoms such as dyspepsia, bloating, and early satiety caused by impaired gastrointestinal motility.

Uses & Indications

Functional dyspepsia

Gastroparesis

Bloating

Early satiety

Nausea and vomiting associated with impaired gastric motility

Dosage

Adults

50 mg three times daily before meals.

Elderly

Dosage adjustment may be considered, start with lower dose.

Renal_impairment

Use with caution; dose reduction may be necessary.

How to Take

Take orally with water, preferably before meals.

Mechanism of Action

Itopride increases acetylcholine concentration by inhibiting dopamine D2 receptors and acetylcholinesterase, thereby enhancing gastrointestinal motility.

Pharmacokinetics

Onset

Within 30-60 minutes.

Excretion

Mainly via urine.

Half life

Approximately 6 hours.

Absorption

Rapidly absorbed from the gastrointestinal tract, bioavailability about 60%.

Metabolism

Extensively metabolized in the liver mainly by flavin-containing monooxygenase (FMO3).

Side Effects

Contraindications

Patients with known hypersensitivity to Itopride or any component of the tablet
Patients with gastrointestinal hemorrhage, mechanical obstruction, or perforation

Drug Interactions

Warfarin

Potential for increased INR, monitor closely.

Anticholinergics

May reduce the effect of Itopride.

Sucralfate, Cimetidine, Ranitidine

May reduce absorption of Itopride if given concurrently; separate administration times.

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

Symptoms may include increased severity of side effects. Treatment is symptomatic and supportive. Gastric lavage may be considered.

Pregnancy & Lactation

Use in pregnancy and lactation only if clearly needed and the potential benefits outweigh the potential risks, as studies are limited. Consult a doctor.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets30 tablets (3x10's)

Shelf Life

3 years

Availability

Pharmacies, Hospitals

Approval Status

Approved by DGDA (Bangladesh)

Patent Status

Generic available, patent expired for active ingredient

Clinical Trials

Numerous clinical trials have demonstrated Itopride's efficacy in treating functional dyspepsia and other motility disorders.

Lab Monitoring

No specific routine lab monitoring required, but monitor for signs of increased prolactin if long-term use.

Doctor Notes

Consider dose adjustment in elderly and renally impaired patients.
Monitor for extrapyramidal symptoms, though rare.
Advise patients on lifestyle modifications to complement therapy.

Patient Guidelines

Take as directed by your doctor.
Do not exceed the recommended dose.
Inform your doctor about all other medications you are taking.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.