Medicine Information

Kafu

Name: Kafu
Brand: Kafu
Rating: 4.5 (117 reviews)

Syrup1 mg/5 mlAntihistamine (Second Generation)ATC: R06AX31

Generic Name

Kafu (Hypothetical Antihistamine)

Manufacturer

PharmaCo Bangladesh Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
kafu 1 mg syrup	৳ 60.00	N/A

Description

Overview of the medicine

Kafu 1 mg Syrup is an advanced second-generation antihistamine used to relieve symptoms associated with allergic conditions such as seasonal allergic rhinitis, perennial allergic rhinitis, and chronic idiopathic urticaria. It provides effective relief from sneezing, runny nose, itchy eyes, and skin rashes without causing significant drowsiness.

Uses & Indications

Relief of symptoms associated with seasonal allergic rhinitis (e.g., sneezing, rhinorrhea, pruritus, ocular itching).

Relief of symptoms associated with perennial allergic rhinitis.

Treatment of uncomplicated skin manifestations of chronic idiopathic urticaria (e.g., relief of pruritus and reduction in the number and size of hives).

Dosage

Adults

Adults and adolescents 12 years and older: 5 ml (1 mg) once daily. In some cases, dosage may be increased to 10 ml (2 mg) once daily if needed. Children 2-12 years: 2.5 ml (0.5 mg) once daily; for children weighing more than 30 kg, 5 ml (1 mg) once daily.

Elderly

No specific dose adjustment is generally required in the elderly unless there is renal impairment. Use with caution.

Renal_impairment

For patients with moderate to severe renal impairment (creatinine clearance <50 mL/min), the initial dose should be reduced (e.g., 2.5 ml or 0.5 mg once daily).

How to Take

Kafu syrup is for oral administration. It can be taken with or without food. Use the provided measuring cup or spoon to ensure accurate dosing.

Mechanism of Action

Kafu acts as a selective peripheral H1 receptor antagonist. It blocks the action of histamine, a natural substance in the body that causes allergic symptoms, by binding to H1 receptors. This prevents histamine from triggering symptoms like itching, sneezing, and inflammation.

Pharmacokinetics

Onset

Symptom relief typically begins within 30-60 minutes.

Excretion

Mainly excreted through the urine, with a minor portion eliminated in the feces.

Half life

Approximately 10-15 hours, allowing for once-daily dosing.

Absorption

Rapidly absorbed from the gastrointestinal tract following oral administration, with peak plasma concentrations reached within 1-2 hours.

Metabolism

Primarily metabolized in the liver, likely via cytochrome P450 enzymes (e.g., CYP3A4).

Side Effects

Contraindications

Hypersensitivity to the active substance or any of the excipients.
Severe renal impairment (creatinine clearance <10 mL/min).

Drug Interactions

CNS Depressants (e.g., alcohol, sedatives)

Co-administration may potentiate CNS depression, although Kafu typically causes less sedation.

P-glycoprotein inhibitors (e.g., cyclosporine)

May alter absorption and distribution of Kafu.

CYP3A4 Inhibitors (e.g., ketoconazole, erythromycin)

May increase plasma concentrations of Kafu, potentially leading to increased side effects.

Storage

Store below 30°C in a dry place. Protect from light and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose may include drowsiness, somnolence, headache, or tachycardia. In case of overdose, symptomatic and supportive treatment should be initiated. There is no specific antidote for Kafu.

Pregnancy & Lactation

Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. However, there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. It is unknown whether Kafu is excreted in human milk; caution should be exercised when administered to a nursing woman.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

50 ml bottle100 ml bottle

Shelf Life

24 months from the date of manufacture when stored under recommended conditions.

Availability

Available in pharmacies nationwide

Approval Status

Approved by DGDA

Patent Status

Patent Pending

Clinical Trials

Extensive clinical trials have demonstrated the efficacy and safety of Kafu in treating various allergic conditions, with results showing significant symptom reduction and a favorable safety profile.

Lab Monitoring

No routine lab monitoring is generally required for Kafu. However, for long-term use or in patients with pre-existing hepatic/renal impairment, periodic monitoring of liver and renal function tests may be advisable.

Doctor Notes

Emphasize the non-sedating nature compared to older antihistamines but advise caution for initial doses.
Remind patients about potential drug interactions, especially with CNS depressants and CYP inhibitors.
Counsel on proper administration using measuring devices to ensure accurate pediatric dosing.

Patient Guidelines

Do not exceed the recommended dose.
Avoid alcohol consumption while taking this medicine as it may increase drowsiness.
Inform your doctor or pharmacist about all other medicines you are taking, including herbal supplements and over-the-counter drugs.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

Kafu is less likely to cause drowsiness than older antihistamines, but individual reactions vary. Exercise caution when driving or operating machinery until you know how this medicine affects you.