Medicine Information

Keolax

Name: Keolax
Brand: Keolax
Rating: 4.5 (117 reviews)

Tablet10 mgLaxatives; Stimulant LaxativesATC: A06AB02

Generic Name

Bisacodyl

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
keolax 10 mg tablet	৳ 2.77	৳ 27.70

Description

Overview of the medicine

Keolax 10 mg Tablet contains Bisacodyl, a stimulant laxative used for the short-term treatment of constipation. It also helps in bowel evacuation before medical procedures or surgery.

Uses & Indications

Short-term treatment of constipation

Bowel preparation before surgery or diagnostic procedures (e.g., colonoscopy)

Management of neurogenic bowel dysfunction

Dosage

Adults

Oral: 5-15 mg once daily, preferably at bedtime. Max 30 mg/day for bowel preparation.

Elderly

Start with the lowest effective dose.

Renal_impairment

No specific dose adjustment generally required, but caution is advised in severe impairment.

How to Take

Take tablets orally, usually at bedtime. Swallow whole with water, do not chew or crush. Avoid taking within one hour of milk or antacids.

Mechanism of Action

Bisacodyl stimulates the nerves in the colon, causing increased bowel motility and fluid secretion into the colon. This action promotes bowel movements.

Pharmacokinetics

Onset

Oral: 6-12 hours; Rectal: 15-60 minutes.

Excretion

Primarily excreted via feces, with a small amount excreted renally as glucuronide conjugates.

Half life

The active metabolite BHPM has a plasma half-life of about 16 hours.

Absorption

Poorly absorbed systemically after oral administration; primarily acts locally in the colon.

Metabolism

Metabolized in the liver to the active metabolite BHPM via esterase enzymes.

Side Effects

Contraindications

Acute abdominal conditions (e.g., appendicitis, acute inflammatory bowel disease)
Severe dehydration
Intestinal obstruction
Hypersensitivity to Bisacodyl or any component
Severe abdominal pain with nausea and vomiting

Drug Interactions

Diuretics

May increase the risk of electrolyte imbalance.

Corticosteroids

May increase the risk of electrolyte imbalance.

Antacids, H2-blockers, Proton pump inhibitors

May cause premature dissolution of the enteric coating, leading to gastric irritation and dyspepsia. Should be taken at least one hour apart.

Storage

Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

Symptoms may include abdominal cramps, diarrhea, and significant fluid and electrolyte loss (especially potassium). Management involves supportive care, correction of fluid and electrolyte imbalance.

Pregnancy & Lactation

Use with caution during pregnancy and lactation only if clearly needed and under medical supervision. Limited human data available.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets in a strip30 tablets in a box

Shelf Life

36 months

Availability

Pharmacies, drugstores

Approval Status

Approved

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Numerous clinical trials have established the efficacy and safety of Bisacodyl for the treatment of constipation and bowel preparation.

Lab Monitoring

In prolonged use or in patients with risk factors, monitor electrolyte levels (especially potassium).

Doctor Notes

Advise patients on appropriate fluid intake and dietary fiber.
Emphasize short-term use and discourage chronic use without medical supervision.
Counsel patients about potential drug interactions, especially with milk and antacids.

Patient Guidelines

Do not use for more than 7 days without consulting a doctor.
Drink plenty of fluids while using this medicine.
Avoid prolonged or excessive use to prevent dependence.
Report any severe abdominal pain or rectal bleeding to your doctor immediately.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose.

Driving Precautions

Generally, Bisacodyl does not affect the ability to drive or operate machinery. However, if you experience dizziness or abdominal discomfort, avoid such activities until symptoms subside.