Medicine Information

Lansec

Name: Lansec
Brand: Lansec
Rating: 4.5 (117 reviews)

Capsule30 mgProton Pump Inhibitor (PPI)ATC: A02BC03

Generic Name

Lansoprazole

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
lansec 30 mg capsule	৳ 6.05	৳ 60.50

Description

Overview of the medicine

Lansec 30 mg Capsule contains Lansoprazole, which is a proton pump inhibitor (PPI). It works by decreasing the amount of acid produced in the stomach, helping to relieve symptoms and heal acid-related damage to the esophagus, stomach, and intestines.

Uses & Indications

Treatment of duodenal ulcers

Treatment of gastric ulcers

Treatment and maintenance of reflux esophagitis

Treatment of Zollinger-Ellison syndrome

Eradication of Helicobacter pylori (in combination with antibiotics)

Treatment of NSAID-associated ulcers

Dosage

Adults

For duodenal ulcer: 30 mg once daily for 4 weeks. For gastric ulcer: 30 mg once daily for 8 weeks. For reflux esophagitis: 30 mg once daily for 4-8 weeks. For H. pylori eradication: 30 mg twice daily for 7-14 days (in combination therapy).

Elderly

Generally no dose adjustment needed. However, caution in elderly patients with severe hepatic impairment.

Renal_impairment

No dose adjustment is necessary for patients with renal impairment.

How to Take

Take the capsule orally, preferably in the morning before breakfast. Swallow whole with water; do not crush or chew the capsule. For patients who have difficulty swallowing, the capsule may be opened and the intact granules sprinkled on a spoonful of applesauce or yogurt.

Mechanism of Action

Lansoprazole is a proton pump inhibitor that suppresses gastric acid secretion by irreversibly inhibiting the H+/K+-ATPase enzyme system (the proton pump) at the secretory surface of the gastric parietal cells. This reduces both basal and stimulated acid secretion.

Pharmacokinetics

Onset

Acid suppression begins within 1-2 hours.

Excretion

Approximately one-third of the dose is excreted in the urine, and two-thirds in the feces (primarily as metabolites).

Half life

Plasma elimination half-life is 1.3 to 2 hours, but the duration of acid suppression is much longer due to irreversible binding to the proton pump.

Absorption

Rapidly absorbed from the gastrointestinal tract. Bioavailability is about 80-90%. Peak plasma concentrations are reached within 1.5-2.2 hours.

Metabolism

Extensively metabolized in the liver, primarily by the cytochrome P450 enzymes CYP2C19 and CYP3A4. The main metabolites are inactive.

Side Effects

Contraindications

Hypersensitivity to lansoprazole or any component of the formulation.
Co-administration with atazanavir.

Drug Interactions

Digoxin

May increase digoxin absorption and levels.

Warfarin

Possible increased INR and bleeding risk.

Atazanavir

Significantly reduces plasma concentrations of atazanavir, contraindicating co-administration.

Iron Salts

May reduce absorption of iron salts due to increased gastric pH.

Clopidogrel

May reduce the antiplatelet effect of clopidogrel by inhibiting CYP2C19.

Methotrexate

May increase methotrexate levels, especially with high-dose methotrexate.

Storage

Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

Limited experience with overdose. Symptoms may include lethargy, tremor, convulsions, and hypothermia. Management is symptomatic and supportive. Lansoprazole is not significantly removed from the circulation by hemodialysis.

Pregnancy & Lactation

Pregnancy Category B. Studies in animals have not shown harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed. It is unknown whether lansoprazole is excreted in human milk; caution should be exercised when administered to a nursing mother.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 capsules20 capsules30 capsules

Shelf Life

Typically 24-36 months from the date of manufacture.

Availability

Available in pharmacies and hospitals nationwide

Approval Status

Approved (DGDA, FDA)

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Lansoprazole has undergone extensive clinical trials demonstrating its efficacy and safety in various acid-related disorders. Ongoing research continues to explore long-term effects and new indications.

Lab Monitoring

Monitor magnesium levels in patients expected to be on long-term treatment or taking PPIs with other drugs such as digoxin or diuretics.
Periodic liver function tests may be considered in patients with pre-existing liver impairment.

Doctor Notes

Prescribe the lowest effective dose for the shortest duration consistent with the treatment goals.
Consider calcium and vitamin D supplementation for patients on long-term PPI therapy.
Be aware of potential drug interactions, especially with clopidogrel and methotrexate.

Patient Guidelines

Take exactly as prescribed by your doctor.
Do not crush, chew, or break the capsule.
Take about 30 minutes before your first meal of the day.
Inform your doctor about all other medications and supplements you are taking.
Report any new or worsening symptoms to your doctor.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

Lansoprazole is generally considered safe for driving. However, if you experience dizziness or visual disturbances, avoid driving or operating machinery.

Lifestyle Advice

Avoid foods and beverages that may worsen acid reflux, such as spicy foods, fatty foods, caffeine, and alcohol.
Elevate the head of your bed to reduce nighttime reflux.
Maintain a healthy weight and quit smoking.