Latuda
Generic Name
Lurasidone
Manufacturer
Sunovion Pharmaceuticals Inc.
Country
USA
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| latuda 40 mg tablet | ৳ 35.00 | ৳ 350.00 |
Description
Overview of the medicine
Latuda (Lurasidone) is an atypical antipsychotic medication used to treat schizophrenia and depressive episodes associated with bipolar I disorder (bipolar depression). It helps restore the balance of certain natural substances in the brain.
Uses & Indications
Dosage
Adults
Schizophrenia: Initial dose 40 mg once daily, maximum 160 mg/day. Bipolar depression: Initial dose 20 mg once daily, maximum 120 mg/day. Administer with food (at least 350 calories).
Elderly
Lower starting doses and slower titration may be considered due to potential for reduced renal/hepatic function and increased sensitivity to adverse effects. Maximum dose of 80 mg/day for moderate to severe renal/hepatic impairment.
Renal_impairment
Moderate (CrCl 30-49 mL/min) and Severe (CrCl <30 mL/min) impairment: Maximum recommended dose is 80 mg/day. End-stage renal disease: Maximum recommended dose is 80 mg/day.
How to Take
Take orally once daily with food (at least 350 calories). Do not crush, chew, or split the tablet.
Mechanism of Action
Lurasidone is thought to exert its therapeutic effects through a combination of antagonism at dopamine D2 and serotonin 5-HT2A and 5-HT7 receptors, and partial agonism at serotonin 5-HT1A receptors. It also has alpha2C-adrenergic antagonism.
Pharmacokinetics
Onset
Clinical improvement may be observed within a few weeks.
Excretion
Approximately 80% is excreted in feces and 9% in urine.
Half life
Approximately 18 hours.
Absorption
Well absorbed after oral administration, bioavailability ~9-19%. Absorption is significantly increased when taken with food (at least 350 calories).
Metabolism
Primarily metabolized by CYP3A4 (cytochrome P450 3A4) enzyme in the liver.
Side Effects
Contraindications
- Concomitant use with strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin, ritonavir)
- Concomitant use with strong CYP3A4 inducers (e.g., rifampin, carbamazepine, phenytoin, St. John's Wort)
Drug Interactions
Strong CYP3A4 Inducers
Decreased Lurasidone exposure, potentially leading to reduced efficacy. Contraindicated.
Strong CYP3A4 Inhibitors
Increased Lurasidone exposure, potentially leading to increased adverse effects. Contraindicated.
Moderate CYP3A4 Inducers (e.g., bosentan)
Increase lurasidone dose if needed and tolerated.
Moderate CYP3A4 Inhibitors (e.g., diltiazem)
Reduce lurasidone dose by half.
Storage
Store at room temperature (20-25°C or 68-77°F); excursions permitted to 15-30°C (59-86°F). Protect from moisture and light. Keep out of reach of children.
Overdose
There is no specific antidote for Lurasidone overdose. Management should include general supportive measures, including maintaining an open airway, ensuring adequate oxygenation and ventilation, and monitoring cardiac function and vital signs. Activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Lurasidone is excreted in breast milk; a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture, specific to manufacturer and packaging.
Availability
Worldwide
Approval Status
FDA Approved
Patent Status
Originally patent protected (now generics available)
Clinical Trials
Lurasidone has undergone extensive clinical trials demonstrating efficacy in the treatment of schizophrenia and bipolar depression. Key trials include the PEARL-1, PEARL-2, and PRIME studies for schizophrenia, and PREVAIL-1 and PREVAIL-2 for bipolar depression.
Lab Monitoring
- Monitor blood glucose and lipid profile periodically due to risk of metabolic changes.
- Monitor weight regularly.
- Complete Blood Count (CBC) and liver function tests may be considered.
Doctor Notes
- Emphasize the importance of taking Latuda with at least 350 calories of food for optimal absorption and efficacy.
- Monitor patients for metabolic changes (weight, glucose, lipids) and emergent movement disorders (akathisia, parkinsonism, tardive dyskinesia).
- Assess for suicidal ideation, especially in children, adolescents, and young adults starting therapy or during dose changes. Counsel patients and caregivers on this risk.
Patient Guidelines
- Take the medicine consistently with food (at least 350 calories) at the same time each day.
- Do not stop taking Latuda suddenly without consulting your doctor, as this can lead to withdrawal symptoms.
- Report any unusual or severe side effects, especially uncontrollable movements, signs of high blood sugar, or thoughts of self-harm, to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and resume your regular dosing schedule. Do not double doses.
Driving Precautions
Lurasidone may cause somnolence, dizziness, or orthostatic hypotension. Patients should be cautioned about operating hazardous machinery, including automobiles, until they are reasonably certain that Lurasidone therapy does not affect them adversely.
Lifestyle Advice
- Avoid alcohol consumption while taking Latuda, as it can worsen side effects like drowsiness.
- Maintain a healthy diet and regular exercise to manage potential weight gain and metabolic changes.
- Do not drive or operate heavy machinery until you know how Latuda affects you, as it may cause drowsiness or dizziness.
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