Limxid
Generic Name
Limaxin 125 mg Tablet
Manufacturer
Pharmalink Bangladesh Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| limxid 125 mg tablet | ৳ 8.00 | ৳ 112.00 |
Description
Overview of the medicine
Limxid 125 mg Tablet is a broad-spectrum antibiotic used to treat various bacterial infections, including respiratory tract infections, skin and soft tissue infections, and urinary tract infections.
Uses & Indications
Dosage
Adults
125 mg every 8-12 hours, or as directed by physician. Duration of treatment varies with infection type and severity, typically 5-10 days.
Elderly
No specific dose adjustment required based on age, but renal and hepatic function should be monitored.
Renal_impairment
For severe renal impairment (CrCl < 30 mL/min), a dose reduction or extended dosing interval may be necessary. Consult physician for specific guidance.
How to Take
Take the tablet orally with a glass of water, with or without food. Complete the full course of treatment as prescribed, even if symptoms improve.
Mechanism of Action
Limaxin, the active ingredient, inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, thereby preventing bacterial growth and replication. It is bacteriostatic at lower concentrations and bactericidal at higher concentrations.
Pharmacokinetics
Onset
Within 1-2 hours of administration.
Excretion
Mainly excreted unchanged in urine (60-70%) and some through bile/feces.
Half life
Approximately 6-8 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract; oral bioavailability approximately 80-90%. Peak plasma concentrations are reached within 1-2 hours.
Metabolism
Primarily hepatic metabolism via the cytochrome P450 system (e.g., CYP3A4).
Side Effects
Contraindications
- Hypersensitivity to Limaxin or any macrolide antibiotic.
- History of cholestatic jaundice/hepatic dysfunction associated with prior Limaxin therapy.
- Concomitant use with certain drugs like cisapride, pimozide, or ergot alkaloids.
Drug Interactions
Digoxin
Increased serum Digoxin levels may occur, monitor Digoxin levels.
Warfarin
May increase the anticoagulant effect, leading to a risk of bleeding. INR monitoring is recommended.
Theophylline
May increase plasma concentrations of Theophylline, requiring dose adjustment.
Antacids (containing Mg/Al)
May decrease the absorption of Limaxin. Take Limaxin at least 2 hours before or 4 hours after antacids.
Ergot Alkaloids (e.g., Ergotamine, Dihydroergotamine)
Concomitant use is contraindicated due to potential for acute ergotism.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptoms may include severe gastrointestinal upset (nausea, vomiting, diarrhea) and possibly transient hearing loss. Treatment is symptomatic and supportive. Gastric lavage and supportive measures should be employed as necessary.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Limaxin is excreted in breast milk; caution should be exercised when administered to a nursing mother. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by DGDA
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Multiple clinical trials have demonstrated the efficacy and safety of Limaxin in treating various bacterial infections, comparing it to placebo and other standard antibiotics.
Lab Monitoring
- Liver function tests (ALT, AST, ALP) if prolonged therapy or pre-existing hepatic impairment.
- Renal function tests (Creatinine, BUN) in patients with renal impairment.
Doctor Notes
- Emphasize patient compliance to complete the full course to prevent resistance.
- Advise monitoring for signs of superinfection and prompt reporting of any severe gastrointestinal symptoms.
- Review concomitant medications for potential interactions, especially with anticoagulants and QT-prolonging drugs.
Patient Guidelines
- Complete the entire prescribed course of Limxid, even if you start feeling better.
- Do not share your medicine with others.
- Inform your doctor about all other medications, supplements, and herbal products you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Generally, Limxid does not impair the ability to drive or operate machinery. However, if you experience dizziness, use caution.
Lifestyle Advice
- Stay hydrated by drinking plenty of fluids.
- Maintain good hygiene to prevent reinfection.
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