Medicine Information

Liset

Name: Liset
Brand: Liset
Rating: 4.5 (117 reviews)

Tablet5 mgAntihistamineATC: R06AE09

Generic Name

Levocetirizine

Manufacturer

Unimed Unihealth Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
liset 5 mg tablet	৳ 2.00 ((50's pack: ৳ 100.00))	N/A

Description

Overview of the medicine

Liset 5 mg tablet is an antihistamine medication used to relieve symptoms of allergies such as runny nose, sneezing, itching, and watery eyes. It is also effective in treating chronic hives (urticaria).

Uses & Indications

Relief of symptoms associated with seasonal allergic rhinitis (hay fever)

Relief of symptoms associated with perennial allergic rhinitis

Treatment of uncomplicated skin manifestations of chronic idiopathic urticaria

Dosage

Adults

The usual recommended dose for adults and adolescents 12 years and older is 5 mg (one tablet) once daily in the evening.

Elderly

No dose adjustment is routinely required in elderly patients with normal renal function. Dose adjustment may be necessary in case of renal impairment.

Renal_impairment

Dose adjustment is required based on creatinine clearance. For CrCl 30-49 mL/min: 5 mg every other day. For CrCl 10-29 mL/min: 5 mg twice a week.

How to Take

Liset 5 mg tablet should be taken orally with or without food. It is generally recommended to take it in the evening due to its potential to cause drowsiness.

Mechanism of Action

Liset (Levocetirizine) works by blocking the action of histamine, a natural substance in the body that causes allergic symptoms. By selectively inhibiting H1-receptors, it reduces allergic reactions.

Pharmacokinetics

Onset

Onset of action typically occurs within 15-30 minutes.

Excretion

Primarily excreted unchanged in the urine, accounting for about 85% of the dose.

Half life

The plasma elimination half-life is approximately 7-10 hours.

Absorption

Rapidly absorbed after oral administration, with peak plasma concentrations reached within approximately 1 hour.

Metabolism

Minimally metabolized; less than 14% of the dose is metabolized in humans.

Side Effects

Contraindications

Known hypersensitivity to levocetirizine, cetirizine, or any component of the tablet.
Patients with severe renal impairment (creatinine clearance less than 10 mL/min) or end-stage renal disease.
Patients undergoing hemodialysis.

Drug Interactions

Ritonavir

Increased plasma levels of levocetirizine have been observed when co-administered with ritonavir.

Central Nervous System (CNS) Depressants

Concurrent use with alcohol or other CNS depressants may lead to additive reductions in alertness and performance.

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose may include drowsiness in adults and agitation or restlessness followed by drowsiness in children. Management includes symptomatic and supportive treatment. There is no specific antidote.

Pregnancy & Lactation

Pregnancy Category B. Levocetirizine should be used during pregnancy only if clearly needed. Excreted into breast milk, therefore, caution should be exercised when administered to a nursing woman.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets20 tablets30 tablets

Shelf Life

Typically 2-3 years from the date of manufacture, specific details on packaging.

Availability

Pharmacies, hospitals

Approval Status

DGDA Approved

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Numerous clinical trials have demonstrated the efficacy and safety of levocetirizine in the treatment of allergic rhinitis and chronic idiopathic urticaria across various patient populations.

Lab Monitoring

No routine laboratory monitoring is generally required for levocetirizine.

Doctor Notes

Advise patients to take this medication in the evening due to potential drowsiness.
Dose adjustment is crucial in patients with renal impairment.
Counsel patients on avoiding alcohol or other CNS depressants during treatment.

Patient Guidelines

Take the medicine exactly as prescribed by your doctor, usually once daily in the evening.
Avoid consuming alcohol or other CNS depressants while on this medication.
Do not exceed the recommended dose.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.

Driving Precautions

Liset may cause drowsiness in some individuals. Patients should be cautioned against engaging in hazardous occupations requiring complete mental alertness, such as driving a motor vehicle or operating heavy machinery, until they know how the drug affects them.

Lifestyle Advice

Identify and avoid allergens that trigger your symptoms.
Maintain adequate hydration.
For chronic urticaria, avoid known triggers like certain foods or physical stimuli if identified.