Medicine Information

micoderm-hc

Name: micoderm-hc
Brand: micoderm-hc
Rating: 4.5 (117 reviews)

CreamMiconazole Nitrate 2% + Hydrocortisone 1%Topical Antifungal & CorticosteroidATC: D07XC01

Generic Name

Miconazole Nitrate + Hydrocortisone

Manufacturer

XYZ Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
micoderm hc 2 1 cream	৳ 50.20	N/A

Description

Overview of the medicine

Micoderm-HC 2/1 Cream is a combination topical medication containing Miconazole Nitrate (an antifungal) and Hydrocortisone (a corticosteroid). It is used to treat fungal skin infections that are accompanied by inflammation, redness, and itching.

Uses & Indications

Tinea pedis (Athlete's foot)

Tinea cruris (Jock itch)

Tinea corporis (Ringworm)

Cutaneous Candidiasis

Other fungal skin infections complicated by inflammation

Dosage

Adults

Apply a thin layer to the affected skin area and surrounding skin once or twice daily, depending on the severity of the condition, for 2-4 weeks or as directed by the physician.

Elderly

No specific dosage adjustment is required for elderly patients. Use as for adults.

Renal_impairment

No dosage adjustment is necessary for topical application in patients with renal impairment.

How to Take

For external use only. Wash and dry the affected area thoroughly before application. Apply a thin layer of cream to the affected skin and gently rub it in until it disappears. Wash hands after use unless hands are the treated area. Do not cover the treated area with occlusive dressings unless advised by a doctor.

Mechanism of Action

Miconazole Nitrate inhibits the biosynthesis of ergosterol, a vital component of fungal cell membranes, leading to increased permeability and eventual cell death. Hydrocortisone, a mild corticosteroid, exerts anti-inflammatory, antipruritic, and vasoconstrictive actions by inhibiting the release of inflammatory mediators.

Pharmacokinetics

Onset

Symptomatic relief of itching and inflammation may be noticed within a few days of starting treatment, with complete resolution of fungal infection typically taking 2-4 weeks.

Excretion

Systemically absorbed components are excreted via urine and feces.

Half life

Systemic half-life data is not clinically significant for topical application due to very low systemic absorption.

Absorption

Minimal systemic absorption of both miconazole and hydrocortisone occurs after topical application to intact skin. Absorption may increase with skin damage, occlusive dressings, or application to large surface areas.

Metabolism

Any systemically absorbed miconazole is metabolized in the liver. Hydrocortisone is also metabolized in the liver.

Side Effects

Contraindications

Hypersensitivity to miconazole, hydrocortisone, other azole antifungals, corticosteroids, or any excipients of the cream.
Viral infections of the skin (e.g., herpes simplex, varicella).
Tuberculosis of the skin.
Acne rosacea, perioral dermatitis, ulcerative conditions of the skin.

Drug Interactions

Warfarin

Although systemic absorption is minimal, theoretically, miconazole can enhance the anticoagulant effect of warfarin. Monitor INR if used concurrently, especially on large surface areas or prolonged use.

Storage

Store below 30°C in a dry place, away from direct sunlight. Do not freeze. Keep out of reach of children.

Overdose

Overdose from topical application is unlikely due to minimal systemic absorption. In case of accidental ingestion, supportive measures should be taken and medical attention sought immediately.

Pregnancy & Lactation

Use during pregnancy and lactation should only be considered if the potential benefit outweighs the potential risk to the fetus or infant. Consult a doctor before use. Avoid applying to large areas of skin or for prolonged periods.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 gm tube15 gm tube20 gm tube

Shelf Life

24 to 36 months from manufacturing date, depending on specific manufacturer.

Availability

Pharmacies nationwide

Approval Status

Generally approved

Patent Status

Generic available

Clinical Trials

The combination of miconazole and hydrocortisone has been extensively studied and widely used clinically for its efficacy and safety in treating fungal infections with associated inflammation.

Lab Monitoring

Not generally required for typical topical use.
For prolonged, extensive use, especially in children, monitoring for adrenal axis suppression may be considered.

Doctor Notes

Emphasize proper patient education regarding application technique, duration of therapy, and avoidance of occlusive dressings.
Caution against prolonged use, especially in children and on facial or intertriginous areas, to minimize corticosteroid-related side effects.
Advise patients to report any signs of worsening infection, severe irritation, or systemic symptoms.

Patient Guidelines

Use this medicine exactly as prescribed by your doctor.
Complete the full course of treatment, even if symptoms improve, to prevent recurrence.
Avoid applying the cream near the eyes, mouth, or other mucous membranes.
Do not share this medicine with others, even if they have similar symptoms.

Missed Dose Advice

If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not apply a double dose to make up for a missed one.

Driving Precautions

Micoderm-HC 2/1 Cream is for topical use only and is not expected to affect the ability to drive or operate machinery.

Lifestyle Advice

Keep the affected skin area clean and dry to aid healing.
Wear loose-fitting clothing to allow air circulation to the affected area.
Avoid scratching the affected area, as this can worsen the infection and inflammation.