Medicine Information

Miki-H

Name: Miki-H
Brand: Miki-H
Rating: 4.5 (117 reviews)

CreamMiconazole Nitrate 2% + Hydrocortisone 1%Topical Antifungal & CorticosteroidATC: D01AC52

Generic Name

Miconazole Nitrate + Hydrocortisone

Manufacturer

Apex Pharmaceuticals Ltd.

Country

Bangladesh

Loading images...

Price Details

Current market pricing information

Variant	Unit Price	Strip Price
miki h 2 1 cream	৳ 40.27	N/A

Description

Overview of the medicine

Miki-H 2-1 Cream is a combination topical medication containing Miconazole Nitrate (an antifungal) and Hydrocortisone (a corticosteroid). It is used to treat fungal skin infections accompanied by inflammation, itching, and redness.

Uses & Indications

Tinea pedis (athlete's foot)

Tinea cruris (jock itch)

Tinea corporis (ringworm)

Candidiasis of skin with inflammation

Inflammatory fungal skin infections

Dosage

Adults

Apply a thin layer to the affected area twice daily (morning and evening) for 2-4 weeks, or as directed by physician. Continue treatment for at least 7 days after symptoms disappear.

Elderly

No specific dosage adjustment required. Use with caution for prolonged periods or on large areas.

Renal_impairment

No specific dosage adjustment required for topical use.

How to Take

For external use only. Wash and dry the affected area before applying the cream. Apply a thin layer and gently rub it into the skin. Wash hands immediately after application.

Mechanism of Action

Miconazole inhibits the biosynthesis of ergosterol, an essential component of fungal cell membranes, leading to increased cell membrane permeability and leakage of cellular contents. Hydrocortisone is a corticosteroid that reduces inflammation, itching, and vasoconstriction by inhibiting the release of inflammatory mediators.

Pharmacokinetics

Onset

Symptomatic relief within a few days; complete fungal eradication may take weeks.

Excretion

Absorbed Miconazole and Hydrocortisone metabolites are primarily excreted in urine and feces.

Half life

Systemic half-life for absorbed components is short, but topical action persists.

Absorption

Minimal systemic absorption through intact skin. Absorption may increase with inflammation, occlusion, or application to large surface areas. Miconazole: <1%. Hydrocortisone: 1-5%.

Metabolism

Absorbed Miconazole is metabolized in the liver; Hydrocortisone is metabolized locally in the skin and systemically in the liver.

Side Effects

Contraindications

Hypersensitivity to Miconazole, Hydrocortisone, or any component of the cream
Viral skin infections (e.g., herpes simplex, varicella)
Tuberculosis of the skin
Acne vulgaris
Perioral dermatitis
Rosacea
Untreated bacterial infections

Drug Interactions

Warfarin

Miconazole, even topical, may enhance the anticoagulant effect of warfarin, leading to increased bleeding risk. Monitor INR.

Other corticosteroids

Concurrent use of other corticosteroids may increase the risk of systemic corticosteroid side effects.

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

Accidental ingestion is unlikely to cause serious effects, but gastric lavage or emesis may be considered if large quantities are ingested. Excessive topical application may lead to local skin irritation or, in rare cases of prolonged use over large areas, systemic corticosteroid effects. Discontinue use and treat symptomatically.

Pregnancy & Lactation

Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Avoid prolonged use or large areas. Exercise caution when used by nursing mothers; avoid application to the breast area to prevent infant exposure.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 gm tube15 gm tube30 gm tube

Shelf Life

24 months

Availability

Pharmacies, hospitals

Approval Status

Approved by health authorities (e.g., DGDA, FDA)

Patent Status

Off-patent (Generic available)

Clinical Trials

Clinical trials have demonstrated the efficacy and safety of Miconazole-Hydrocortisone combination creams for inflammatory fungal infections. Studies confirm superior outcomes compared to monotherapy with either agent.

Lab Monitoring

Not typically required for short-term topical use. For extensive, prolonged use, especially in children, monitoring for systemic corticosteroid effects (e.g., growth monitoring, adrenal function tests) may be considered.

Doctor Notes

Emphasize limited duration of corticosteroid component.
Advise patients on proper application technique and hygiene.
Be aware of potential systemic absorption in infants, young children, and with occlusive dressings.

Patient Guidelines

Use strictly as directed by your doctor.
Do not use for longer than prescribed.
Avoid contact with eyes, mouth, and other mucous membranes.
Do not cover the treated area with bandages or airtight dressings unless instructed by a doctor.
Inform your doctor if symptoms do not improve within 2-4 weeks.

Missed Dose Advice

If a dose is missed, apply it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not apply a double dose.