Medicine Information

Neuratam

Name: Neuratam
Brand: Neuratam
Rating: 4.5 (117 reviews)

Syrup500 mg/5 mlNootropics & Neurotonics / Cerebral ActivatorsATC: N06BX03

Generic Name

Piracetam

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
neuratam 500 mg syrup	৳ 150.00	N/A

Description

Overview of the medicine

Neuratam 500 mg Syrup contains Piracetam, a nootropic agent from the racetam group. It is believed to improve cognitive function, memory, learning ability, and attention by influencing neural and vascular functions.

Uses & Indications

Cognitive and memory disorders (e.g., associated with aging, cerebrovascular accident)

Cortical myoclonus (as an adjunct therapy)

Vertigo and associated balance disorders

Dyslexia in children (as part of a comprehensive program)

Dosage

Adults

Initial dose: 2.4 g/day in 2-3 divided doses. Maintenance dose: 1.2-4.8 g/day in 2-3 divided doses. For syrup (500mg/5ml), this translates to 10-40 ml daily.

Elderly

No specific dose adjustment for elderly, but monitor renal function. Start with a lower dose.

Renal_impairment

Creatinine clearance 50-79 ml/min: 2/3 of usual daily dose in 2-3 divided doses. Creatinine clearance 30-49 ml/min: 1/3 of usual daily dose in 2 divided doses. Creatinine clearance <30 ml/min or end-stage renal disease: Contraindicated.

How to Take

Take orally, with or without food. The daily dose should be divided into 2 or 3 doses. May be mixed with water or other liquids.

Mechanism of Action

Piracetam enhances cognitive function by various mechanisms, including improving the fluidity of neuronal membranes, increasing cerebral blood flow, and modulating neurotransmission (e.g., acetylcholine, glutamate). It also enhances mitochondrial activity and ATP synthesis in brain cells.

Pharmacokinetics

Onset

Cognitive effects may be noticeable within hours to days, but full therapeutic benefits can take several weeks.

Excretion

Excreted primarily unchanged by the kidneys, with approximately 80-100% of the dose recovered in urine within 24-30 hours.

Half life

Plasma half-life is approximately 4-5 hours; CSF half-life is 6-8 hours.

Absorption

Rapid and complete absorption from the gastrointestinal tract. Peak plasma concentrations are achieved within 0.5-1 hour after oral administration.

Metabolism

Piracetam is not metabolized in the human body.

Side Effects

Contraindications

Hypersensitivity to piracetam or any component of the formulation
Severe renal impairment (creatinine clearance <20 ml/min)
Cerebral hemorrhage
Huntington's chorea

Drug Interactions

CNS depressants

May enhance CNS depressant effects when co-administered.

Thyroid hormones

Concomitant use with thyroid extracts can increase the risk of confusion, irritability, and sleep disorders.

Anticoagulants (e.g., Warfarin)

Piracetam may potentiate the effects of anticoagulants, requiring careful monitoring of prothrombin time/INR.

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

Piracetam has a wide margin of safety. Symptoms of overdose are generally mild and may include gastrointestinal discomfort, dizziness, or nervousness. Treatment is symptomatic and supportive; no specific antidote exists.

Pregnancy & Lactation

Pregnancy Category B/C. Avoid use during pregnancy unless the potential benefit outweighs the potential risk to the fetus. Not recommended during breastfeeding as piracetam is excreted in breast milk.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

100 ml bottle200 ml bottle

Shelf Life

2-3 years from manufacturing date, depending on specific formulation and packaging.

Availability

Pharmacies, Hospitals

Approval Status

Approved (DGDA, Bangladesh)

Patent Status

Off-patent

Clinical Trials

Piracetam has been studied in numerous clinical trials for its efficacy in cognitive disorders, myoclonus, and other neurological conditions. While some studies show benefit, the evidence for its broad use in cognitive enhancement is debated in some regions.

Lab Monitoring

Renal function tests (especially in elderly or patients with pre-existing renal impairment)

Doctor Notes

Assess renal function before initiating and periodically during piracetam therapy.
Counsel patients on potential central nervous system side effects (e.g., nervousness, insomnia) and the importance of not discontinuing abruptly.
Consider drug interactions, especially with anticoagulants and thyroid hormones.

Patient Guidelines

Take the medicine exactly as prescribed by your doctor.
Do not stop taking Piracetam suddenly, as it may lead to withdrawal symptoms, especially in myoclonus.
It may take several weeks to see the full therapeutic benefits.
Inform your doctor about all other medicines you are taking, including herbal supplements.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

Piracetam may cause drowsiness, dizziness, or nervousness in some individuals. Patients should be cautioned about operating machinery or driving until they know how the drug affects them.