Medicine Information

Olpres-HZ

Name: Olpres-HZ
Brand: Olpres-HZ
Rating: 4.5 (117 reviews)

TabletOlmesartan medoxomil 20 mg and Hydrochlorothiazide 12.5 mgAntihypertensiveATC: C09DA08

Generic Name

Olmesartan medoxomil 20 mg and Hydrochlorothiazide 12.5 mg tablet

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

Loading images...

Price Details

Current market pricing information

Variant	Unit Price	Strip Price
olpres hz 20 mg tablet	৳ 8.00	৳ 80.00

Description

Overview of the medicine

Olpres-HZ 20 mg Tablet is a combination medicine containing Olmesartan medoxomil, an angiotensin II receptor blocker, and Hydrochlorothiazide, a thiazide diuretic. It is primarily used to treat high blood pressure (hypertension) when monotherapy is not sufficient. This combination helps to lower blood pressure by relaxing blood vessels and increasing the excretion of salt and water from the body.

Uses & Indications

Treatment of essential hypertension

When blood pressure is not adequately controlled with olmesartan medoxomil or hydrochlorothiazide alone

Dosage

Adults

Usually 1 tablet once daily. The dose can be adjusted based on individual response and tolerability, typically after 2-4 weeks of therapy.

Elderly

No specific dose adjustment is usually required for elderly patients with normal renal function. Close monitoring is advised.

Renal_impairment

Not recommended for patients with severe renal impairment (creatinine clearance <30 mL/min). For moderate impairment, close monitoring of potassium and creatinine levels is recommended.

How to Take

Take orally once daily, with or without food. Swallow the tablet whole with a glass of water. It is advisable to take the medicine at the same time each day.

Mechanism of Action

Olmesartan medoxomil selectively blocks the AT1 angiotensin II receptor, preventing vasoconstriction and aldosterone release. Hydrochlorothiazide is a thiazide diuretic that acts on the renal distal convoluted tubule to inhibit sodium and chloride reabsorption, leading to increased urinary excretion of water and electrolytes, thereby reducing blood volume and blood pressure.

Pharmacokinetics

Onset

Blood pressure reduction is noticeable within approximately 2 hours for both components, with the full antihypertensive effect developing over 1-2 weeks for olmesartan.

Excretion

Olmesartan is eliminated via biliary excretion (50-65%) and renal excretion (35-50%). Hydrochlorothiazide is predominantly eliminated unchanged by renal excretion.

Half life

The elimination half-life of olmesartan is approximately 13 hours. The half-life of hydrochlorothiazide is between 5.6 and 14.8 hours.

Absorption

Olmesartan medoxomil is rapidly and completely converted to active olmesartan during absorption from the gastrointestinal tract. Its absolute bioavailability is approximately 26%. Hydrochlorothiazide is rapidly absorbed from the gastrointestinal tract with a bioavailability of 60-80%.

Metabolism

Olmesartan is not metabolized by the cytochrome P450 system; it is almost entirely excreted unchanged. Hydrochlorothiazide is not metabolized and is eliminated rapidly by the kidney.

Side Effects

Contraindications

Anuria
Hypersensitivity to olmesartan, hydrochlorothiazide, or sulfonamide-derived drugs
Severe renal impairment
Severe hepatic impairment
Pregnancy (second and third trimesters)

Drug Interactions

NSAIDs

Reduced antihypertensive effect and increased risk of renal impairment, especially in dehydrated patients. Monitor renal function.

Lithium

Increased serum lithium concentrations and lithium toxicity. Monitor serum lithium levels.

Alcohol/Barbiturates/Narcotics

Potentiation of orthostatic hypotension.

Cholestyramine/Colestipol resins

May impair absorption of hydrochlorothiazide. Administer these agents separately.

Insulin/Oral hypoglycemic agents

Dosage adjustment of antidiabetic agents may be required as thiazides can decrease glucose tolerance.

Potassium-sparing diuretics/Potassium supplements

Increased risk of hyperkalemia. Avoid concomitant use unless closely monitored.

Storage

Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

Symptoms may include hypotension, tachycardia, bradycardia (due to vagal stimulation), and electrolyte disturbances (hypokalemia, hyponatremia). Treatment is symptomatic and supportive. Induce emesis or perform gastric lavage if ingestion is recent. Administer activated charcoal. Monitor vital signs and electrolytes.

Pregnancy & Lactation

Contraindicated in the second and third trimesters of pregnancy due to risk of fetal injury or death. Discontinue if pregnancy is detected. Not recommended during lactation as both components are excreted in breast milk.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets (1x10)30 tablets (3x10)

Shelf Life

24 months

Availability

Pharmacies, hospitals, clinics

Approval Status

Approved by major regulatory bodies

Patent Status

Generic available (Patent expired)

Clinical Trials

Extensive clinical trials have demonstrated the efficacy and safety of Olmesartan/Hydrochlorothiazide in reducing blood pressure in hypertensive patients. Studies show a significant additive effect when compared to monotherapy.

Lab Monitoring

Serum electrolytes (potassium, sodium)
Renal function (creatinine, BUN)
Liver function tests
Uric acid levels
Blood glucose (especially in diabetic patients)

Doctor Notes

Caution in patients with volume depletion or severe congestive heart failure.
Monitor renal function and serum electrolytes regularly.
Avoid in pregnant women, especially during the second and third trimesters.
Educate patients on symptoms of hypotension and electrolyte imbalance.

Patient Guidelines

Take the medicine exactly as prescribed by your doctor.
Do not stop taking the medicine without consulting your doctor, even if you feel well.
Report any unusual side effects or symptoms to your doctor immediately.
Avoid driving or operating machinery until you know how this medicine affects you, as it may cause dizziness.
Limit alcohol intake while on this medication.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

This medicine may cause dizziness or lightheadedness, especially at the start of treatment or when changing dose. Patients should be cautious when driving or operating machinery until they determine how the medication affects them.